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View Structure Prediction Details

Protein: Dok-PA
Organism: Drosophila melanogaster
Length: 622 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Dok-PA.

Description E-value Query
Range
Subject
Range
gi|54643459, gi|... - gi|54643459|gb|EAL32203.1| GA15227-PA [Drosophila pseudoobscura], gi|125982729|ref|XP_001355146.1| G...
258.0 [0..1] [566..1]

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Predicted Domain #1
Region A:
Residues: [1-238]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDVEIPVLAG YLNVPTQTGF SLNRISKKKA CSRYCLLFKA SRHGIARLEM CESKEDRNPK  60
   61 IFTLENCVKI TQEPPPERLI HIVKRQATLT LSTSSEEELK DWITALQTVA FCDTSPSGGI 120
  121 GAIEEDNDLY CSSFDGLFII TLIPSEASIR CCIEPKTYML QMTPTELQLK SEDLGATIAM 180
  181 WPYRFIRKYG YRDGKFTFEA GRKCTTGEGV FTLDHTNPQE VFRCMSAKMK SMKKLISG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 60.522879
Match: 1qqgA
Description: Insulin receptor substrate 1, IRS-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.65091781683225 bayes_pls_golite062009
cytoskeletal protein binding 2.36862097678996 bayes_pls_golite062009
actin binding 2.33076715684475 bayes_pls_golite062009
protein binding 2.12168271674167 bayes_pls_golite062009
actin filament binding 1.07760654703512 bayes_pls_golite062009
GTPase regulator activity 0.355387992614734 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 0.335498703113274 bayes_pls_golite062009
enzyme regulator activity 0.189879136353541 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [239-337]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSLSTLECGE NQFSAAAGME PGSRSPLPPS PSSNPHGGEF EINSTQSCIS LRGFISSNDS  60
   61 LNNFSAGGGG ASGATATGGG VLGSTGGITL SVPANSNSN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [338-531]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSSSKHIPNK PPRKSPTTHC DKYRNIVKYE PVAITTISSP SANSDVNSSV ILKPLEGESI  60
   61 SLPETAADLP PDLPLRNESA SKAPPPERDY ECIENITEAW RTRGVGDVRH SERMPILCDT 120
  121 SEFVRQRSVS KSTCGSQNTP KIIDIDIGEG CTSATSISES NYDRLDFLSP NNKTSSGYKT 180
  181 IVNVTPGNRI RCSP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [532-622]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPPNEYELIA SPDTESFRKA DDSHRGYGVL RKASTTTNNN NLGISNSNIS GGSSTITTAT  60
   61 ANKGGNLEAA AIDHRSYNGL NYTMVSKPKR V

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle