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Protein Overview: XRCC1-PA

General Information:
Name(s) found: XRCC1-PA / FBpp0070730 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene XRCC1 is referred to in FlyBase by the symbol Dmel\XRCC1 (CG4208, FBgn0026751). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:5223944..5226468. It has the cytological map location 4F5. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: damaged DNA binding. There is experimental evidence that it is involved in the biological process</span>: base-excision repair, AP site formation; cellular response to DNA damage stimulus. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 614 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA]
    Biological Process: single strand break repair [IEA]
    base-excision repair, AP site formation [IMP]
    nucleotide-excision repair [ISS][NAS]
    response to DNA damage stimulus [IMP]
    Molecular Function: damaged DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPIALFKSVR EVSSEDAVHV AANLLKENAG KKWRTKAPGE KSAYVVLEFE EPQQITGIDI  60
   61 GNEHAAFIEV LVSRTGCQAD DFRELLLSSS FMTPIESKNS SNPNRVRCFS STSLAESALP 120
  121 EKWKLLQIVC TQPFNRHVPY GLSFVKVHVV AAAAPKVKSL VPQGVMQFGT FKLREESPDS 180
  181 ETDNQVNRFH SWKKQTQHKS PAISATSTAA AIRDAGSTAL RRLSAGKVSS LAASPKTSTS 240
  241 PSPVLNALRS VSPTPLDAKP LDRNRASLLF GDDDEDVKDA EVNAKKQRLS KHLEADKDRR 300
  301 RLEQEKERES RKKKSSRHSL DKSISKEDKP PAKEHNSSSR EKSTAKEEKE QLRKEERSHS 360
  361 KEEKSRRKEK SKHDHRSSDT SNSKESSRPT AQKRHSSPTA VAVTPAKKQK IVDTAIQYRP 420
  421 LNQLLKGVVL VISGIQNPDR ADLRSKAVAL GAKYKADWGS GCTHLICAFK NTPKYNQVKG 480
  481 KGKIVTRSWI EKCYELKKYL PWRRYALDTN DIGQPESDEE LCDEATRPRR DSSKDDVAML 540
  541 EDSKLTALAD QNDVEMNPDA LSGIDTEDEL QRVAEENKTK KAKLRTTVKT KSQDIYEVST 600
  601 DEEDYLELKK KQID

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..197] PSI-BLAST 42.69897 N-terminal domain of xrcc1
    2 View Details [198..284] deduced N/A No confident structure predictions are available.
    3 View Details [285..403] FFAS03 1.14 No description for 2j63A was found.
    4 View Details [404..516] PSI-BLAST 9.522879 No description for 2d8mA was found.
    5 View Details [517..614] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  0.385277722045402 bayes_pls_golite062009
  • catalytic activity
    		•  0.248020161559829 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle