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Protein Overview: FBpp0307831, Fas2-PA

General Information:
Name(s) found: FBpp0307831 [FlyBase]
Fas2-PA / FBpp0070633 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • type=protein; loc=X:complement(4028813..4028936,4029444..4029530,4030602..4030803,4035804..4035987,4036083..4037576,4037660..4037784,4043421..4043584,4048618..4048789,4097224..4097293); ID=FBpp0307831; name=Fas2-PE; parent=FBgn0000635,FBtr0336883; dbxref=REFSEQ:NP_001259236,GB_protein:AGB95082,FlyBase:FBpp0307831,FlyBase_Annotation_IDs:CG3665-PE; MD5=ffb796f17b2181742d026185c7b23b68; length=873; release=r5.56; species=Dmel; [FlyBase]
  • The gene Fasciclin 2 is referred to in FlyBase by the symbol Dmel\Fas2 (CG3665, FBgn0000635). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:4028405..4100123. It has the cytological map location 4B1-4B3. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence for 13 unique biological process</span> terms, many of which group under: anatomical structure development; regulation of developmental process; regulation of anatomical structure size; organ development; synapse organization; open tracheal system development; regulation of cellular component organization; homophilic cell adhesion; cell recognition; learning or memory. 65 alleles are reported. The phenotypes of these alleles are annotated with 43 unique terms, many of which group under: nervous system; peripheral nervous system; organ system; multi-cell-component structure; embryonic neuron; embryonic nervous system; adult segment; adult mesothoracic segment; mushroom body; RP1 neuron; anterior orbital bristle; adult neuromuscular junction; embryonic tracheal system; anterior vertical bristle; endocrine system; abdominal segmental nerve; embryonic ganglionic branch; synapse; imaginal precursor; embryonic dorsal trunk; external compound sense organ; female germline cyst; neuromuscular junction. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 873 amino acids

    Gene Ontology:
    Cellular Component: presynaptic membrane [IMP][TAS]
    postsynaptic membrane [IDA][TAS]
    cytoplasm [IDA]
    integral to membrane [TAS]
    neuromuscular junction [IDA]
    cell projection [IDA]
    plasma membrane [IDA][NAS]
    axon [TAS]
    Biological Process: regulation of cell shape [IMP]
    mushroom body development [IMP]
    synapse organization [IMP]
    regulation of synaptic growth at neuromuscular junction [IMP]
    regulation of tube architecture, open tracheal system [TAS]
    neuron recognition [IDA][NAS]
    olfactory learning [TAS]
    cell morphogenesis involved in neuron differentiation [IMP]
    homophilic cell adhesion [IDA]
    behavioral response to ethanol [NAS][TAS]
    learning [TAS]
    imaginal disc-derived male genitalia morphogenesis [IMP]
    axonal fasciculation [NAS][TAS]
    learning or memory [IMP][NAS]
    neuromuscular junction development [IDA][IMP][TAS]
    short-term memory [TAS]
    Bolwig's organ morphogenesis [IEP][IMP]
    regulation of synapse structure and activity [TAS]
    regulation of tube diameter, open tracheal system [IMP]
    regulation of tube length, open tracheal system [IMP]
    Molecular Function: protein binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGELPPNSVG VFLALLLCSC SLIELTRAQS PILEIYPKQE VQRKPVGKPL ILTCRPTVPE  60
   61 PSLVADLQWK DNRNNTILPK PNGRNQPPMY TETLPGESLA LMITSLSVEM GGKYYCTASY 120
  121 ANTEILEKGV TIKTYVAITW TNAPENQYPT LGQDYVVMCE VKADPNPTID WLRNGDPIRT 180
  181 TNDKYVVQTN GLLIRNVQES DEGIYTCRAA VIETGELLER TIRVEVFIQP EIISLPTNLE 240
  241 AVEGKPFAAN CTARGKPVPE ISWIRDATQL NVATADRFQV NPQTGLVTIS SVSQDDYGTY 300
  301 TCLAKNRAGV VDQKTKLNVL VRPQIYELYN VTGARTKEIA ITCRAKGRPA PAITFRRWGT 360
  361 QEEYTNGQQD DDPRIILEPN FDEERGESTG TLRISNAERS DDGLYQCIAR NKGADAYKTG 420
  421 HITVEFAPDF SHMKELPPVF SWEQRKANLS CLAMGIPNAT IEWHWNGRKI KDLYDTNLKI 480
  481 VGTGPRSDLI VHPVTRQYYS GYKCIATNIH GTAEHDMQLK EARVPDFVSE AKPSQLTATT 540
  541 MTFDIRGPST ELGLPILAYS VQYKEALNPD WSTAYNRSWS PDSPYIVEGL RPQTEYSFRF 600
  601 AARNQVGLGN WGVNQQQSTP RRSAPEEPKP LHNPVQHDKE EPVVVSPYSD HFELRWGVPA 660
  661 DNGEPIDRYQ IKYCPGVKIS GTWTELENSC NTVEVMETTS FEMTQLVGNT YYRIELKAHN 720
  721 AIGYSSPASI IMKTTRGIDV IQVAERQVFS SAAIVGIAIG GVLLLLFVVD LLCCITVHMG 780
  781 VMATMCRKAK RSPSEIDDEA KLGSGQLVKE PPPSPLPLPP PVKLGGSPMS TPLDEKEPLR 840
  841 TPTGSIKQNS TIEFDGRFVH SRSGEIIGKN SAV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..719] PSI-BLAST 56.39794 Model of human carcinoembryonic antigen by homology modelling and curve-fitting to experimental solution scattering data
    2 View Details [720..873] PSI-BLAST 13.0 FRAGMENT OF HUMAN FIBRONECTIN ENCOMPASSING TYPE-III REPEATS 7 THROUGH 10


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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