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Protein Overview: ph-p-PA

General Information:
Name(s) found: ph-p-PA / FBpp0070416 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene polyhomeotic proximal is referred to in FlyBase by the symbol Dmel\ph-p (CG18412, FBgn0004861). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:2020243..2030888. It has the cytological map location 2D2-2D3. There is experimental evidence that it has the molecular function</span>: chaperone binding; protein binding; chromatin binding. There is experimental evidence that it is involved in the biological process</span>: central nervous system neuron development; gene silencing; germarium-derived female germ-line cyst encapsulation; ovarian follicle cell stalk formation; response to ecdysone; syncytial blastoderm mitotic cell cycle. 44 alleles are reported. The phenotypes of these alleles are annotated with 20 unique terms, many of which group under: adult segment; organ system; germarium; female germline cyst; peripheral nervous system; metatarsus; adult mesothoracic segment; nervous system; germarium region 3; adult external prothorax; larval abdominal segment; external compound sense organ. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1589 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][NAS]
    PRC1 complex [TAS]
    nucleolus [IDA]
    Biological Process: gene silencing [IGI]
    ovarian follicle cell stalk formation [IMP]
    response to ecdysone [IMP]
    syncytial blastoderm mitotic cell cycle [IMP]
    germarium-derived female germ-line cyst encapsulation [IMP]
    chromatin silencing [NAS]
    central nervous system neuron development [IMP]
    Molecular Function: DNA binding [NAS]
    zinc ion binding [IEA]
    protein binding [IPI]
    chaperone binding [IDA]
    chromatin binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDRRALKFMQ KRADTESDTT TPVSTTASQG ISASAILAGG TLPLKDNSNI REKPLHHNYN  60
   61 HNNNNSSQHS HSHQQQQQQQ VGGKQLERPL KCLETLAQKA GITFDEKYDV ASPPHPGIAQ 120
  121 QQATSGTGPA TGSGSVTPTS HRHGTPPTGR RQTHTPSTPN RPSAPSTPNT NCNSIARHTS 180
  181 LTLEKAQNPG QQVAATTTVP LQISPEQLQQ FYASNPYAIQ VKQEFPTHTT SGSGTELKHA 240
  241 TNIMEVQQQL QLQQQLSEAN GGGAASAGAG GAASPANSQQ SQQQQHSTAI STMSPMQLAA 300
  301 ATGGVGGDWT QGRTVQLMQP STSFLYPQMI VSGNLLHPGG LGQQPIQVIT AGKPFQGNGP 360
  361 QMLTTTTQNA KQMIGGQAGF AGGNYATCIP TNHNQSPQTV LFSPMNVISP QQQQNLLQSM 420
  421 AAAAQQQQLT QQQQQFNQQQ QQQLTQQQQQ LTAALAKVGV DAQGKLAQKV VQKVTTTSSA 480
  481 VQAATGPGST GSTQTQQVQQ VQQQQQQTTQ TTQQCVQVSQ STLPVGVGGQ SVQTAQLLNA 540
  541 GQAQQMQIPW FLQNAAGLQP FGPNQIILRN QPDGTQGMFI QQQPATQTLQ TQQNQIIQCN 600
  601 VTQTPTKART QLDALAPKQQ QQQQQVGTTN QTQQQQLAVA TAQLQQQQQQ LTAAALQRPG 660
  661 APVMPHNGTQ VRPASSVSTQ TAQNQSLLKA KMRNKQQPVR PALATLKTEI GQVAGQNKVV 720
  721 GHLTTVQQQQ QATNLQQVVN AAGNKMVVMS TTGTPITLQN GQTLHAATAA GVDKQQQQLQ 780
  781 LFQKQQILQQ QQMLQQQIAA IQMQQQQAAV QAQQQQQQQV SQQQQVNAQQ QQAVAQQQQA 840
  841 VAQAQQQQRE QQQQVAQAQA QHQQALANAT QQILQVAPNQ FITSHQQQQQ QQLHNQLIQQ 900
  901 QLQQQAQAQV QAQVQAQAQQ QQQQREQQQN IIQQIVVQQS GATSQQTSQQ QQHHQSGQLQ 960
  961 LSSVPFSVSS STTPAGIATS SALQAALSAS GAIFQTAKPG TCSSSSPTSS VVTITNQSST1020
 1021 PLVTSSTVAS IQQAQTQSAQ VHQHQQLISA TIAGGTQQQP QGPPSLTPTT NPILAMTSMM1080
 1081 NATVGHLSTA PPVTVSVTST AVTSSPGQLV LLSTASSGGG GSIPATPTKE TPSKGPTATL1140
 1141 VPIGSPKTPV SGKDTCTTPK SSTPATVSAS VEASSSTGEA LSNGDASDRS STPSKGATTP1200
 1201 TSKQSNAAVQ PPSSTTPNSV SGKEEPKLAT CGSLTSATST STTTTITNGI GVARTTASTA1260
 1261 VSTASTTTTS SGTFITSCTS TTTTTTSSIS NGSKDLPKAM IKPNVLTHVI DGFIIQEANE1320
 1321 PFPVTRQRYA DKDVSDEPPK KKATMQEDIK LSGIASAPGS DMVACEQCGK MEHKAKLKRK1380
 1381 RYCSPGCSRQ AKNGIGGVGS GETNGLGTGG IVGVDAMALV DRLDEAMAEE KMQTEATPKL1440
 1441 SESFPILGAS TEVPPMSLPV QAAISAPSPL AMPLGSPLSV ALPTLAPLSV VTSGAAPKSS1500
 1501 EVNGTDRPPI SSWSVDDVSN FIRELPGCQD YVDDFIQQEI DGQALLLLKE KHLVNAMGMK1560
 1561 LGPALKIVAK VESIKEVPPP GEAKDPGAQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..102] deduced N/A No confident structure predictions are available.
    2 View Details [103..173] deduced N/A No confident structure predictions are available.
    3 View Details [174..232] deduced N/A No confident structure predictions are available.
    4 View Details [233..396] deduced N/A No confident structure predictions are available.
    5 View Details [397..609] deduced N/A No confident structure predictions are available.
    6 View Details [610..787] deduced N/A No confident structure predictions are available.
    7 View Details [788..910] deduced N/A No confident structure predictions are available.
    8 View Details [911..1114] deduced N/A No confident structure predictions are available.
    9 View Details [1115..1306] deduced N/A No confident structure predictions are available.
    10 View Details [1307..1379] deduced N/A No confident structure predictions are available.
    11 View Details [1380..1473] deduced N/A No confident structure predictions are available.
    12 View Details [1474..1589] PSI-BLAST 31.0 Hetero SAM domain structure of Ph and Scm.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.
    11 No functions predicted.
    12
    Term Confidence Notes
  • binding
    		•  0.633600780660145 bayes_pls_golite062009
  • protein binding
    		•  0.29861856894481 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.71

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle