YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: Rbf-PA

General Information:
Name(s) found: Rbf-PA / FBpp0070141 [FlyBase]
Description(s) found:
Found 25 descriptions.
SHOW ALL
  • The gene Retinoblastoma-family protein is referred to in FlyBase by the symbol Dmel\Rbf (CG7413, FBgn0015799). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:691121..695490. It has the cytological map location 1C5. There is experimental evidence that it has the molecular function</span>: transcription factor binding; promoter binding. There is experimental evidence that it is involved in the biological process</span>: G1 phase of mitotic cell cycle; negative regulation of gene expression; negative regulation of S phase of mitotic cell cycle; regulation of DNA binding; negative regulation of transcription from RNA polymerase II promoter; regulation of cell cycle; negative regulation of DNA replication; DNA endoreduplication. 46 alleles are reported. The phenotypes of these alleles are annotated with 15 unique terms, many of which group under: peripheral nervous system; external compound sense organ; adult segment; nervous system; adult mesothoracic segment; organ system; compound cell cluster organ; female germline cyst; cell part; cell cycle; imaginal precursor. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 845 amino acids

    Gene Ontology:
    Cellular Component: nucleus [NAS]
    Rb-E2F complex [IDA][TAS]
    Myb complex [IDA]
    chromatin [IDA]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [IDA][IGI][IMP]
    negative regulation of gene expression [IMP]
    regulation of DNA binding [IDA]
    eggshell chorion gene amplification [TAS]
    negative regulation of S phase of mitotic cell cycle [IMP]
    negative regulation of cell proliferation [NAS]
    endomitotic cell cycle [TAS]
    G1 phase of mitotic cell cycle [IMP]
    DNA endoreduplication [IMP]
    regulation of cell cycle [IMP][ISS]
    negative regulation of DNA replication [IMP]
    Molecular Function: DNA binding [NAS]
    transcription factor binding [IPI]
    promoter binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEPDPQELG AEVVSGLVAT SDDRLEMINA EYTNLCRDLN MDRQTELQGY ETYLEVSQRC  60
   61 SMEGTASHWM CCAIYTACRR TSTPTVTGQN AVVKGNCVSL NNLLRCCKMS IYEFKTKIKQ 120
  121 WCDMANLPQE FVNEIEDLDR KFSITFMLHK RFRIIMDMIF SCPPNEKKHS KYISLHGNHA 180
  181 HGKCSYIKLD DICWRLFLCA KNQKPSNTVD LVTSYNLMIC CIDLIYNNVL AEKRTDLINP 240
  241 KFEGLPSNWT ELDFRHNPHC ILSNFCDMTE EAKAMKATTF RQIMSSFFQA STIYGNKDTM 300
  301 LGLLANENFE RNLKSLNISY EQYVLSVGEF DERILSAYDA GEHTALNDQS LRPPVTPLTR 360
  361 KQDLPAQPAM AGDKFEPVRN ATNNVKQLSA FGRITEPTDF VKQAGEEVIA KLLSIIEEIE 420
  421 QKFLAKYPST EAKSRFQLAK SFFFYLLDQI LQAEIRNKPD IDLKRLLVQK VSLVIFNITL 480
  481 MACCVELVLE AYKTELKFPW VLDCFSISAF EFQKIIEIVV RHGSHEGCLN RSLIKHLNSI 540
  541 EETCLERLAW ARNSTVWEMI ASAQLPLPTW LMVNLDRAAG PLQIFLRKVY LLGWLRIQKL 600
  601 CSELSLCEKT PESIWHIFEH SITHETELMK DRHLDQNIMC AIYIYIRVKR MEDPKFSDIM 660
  661 RAYRNQPQAV NSVYREVFID INEDGEPKVK DIIHFYNHTY VPLMRQFVID YLNVTPDVSG 720
  721 RASDLQLSPH PKERAAQPKK VTQSHSLFVS QMSKNEIQQS PNQMVYSFCR SPAKDLQAMN 780
  781 EKVRGGKRML SFGDEPGLGT MAETKRSKIS QVKAVMDDPE LQSAEQQTAV TTEGCVGGEG 840
  841 GEHET

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..173] PSI-BLAST 13.0 Transcription factor IIB (TFIIB), core domain
    2 View Details [174..240] MSA 2.053997 View MSA. No confident structure predictions are available.
    3 View Details [241..372] MSA 1.055997 View MSA. No confident structure predictions are available.
    4 View Details [373..772] PSI-BLAST 118.0 No description for 2r7gA was found.
    5 View Details [773..845] MSA 2.022996 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle