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Protein Overview: unc-13-PB

General Information:
Name(s) found: unc-13-PB / FBpp0088307 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene unc-13 is referred to in FlyBase by the symbol Dmel\unc-13 (CG2999, FBgn0025726). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 4:891551..925419. It has the cytological map location 102E5-102F1. Based on sequence similarity, it is predicted to have molecular function</span>: diacylglycerol binding. There is experimental evidence that it is involved in the biological process</span>: synaptic transmission; synaptic vesicle exocytosis. 7 alleles are reported. The phenotype of these alleles is annotated with: synaptic vesicle. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 3183 amino acids

    Gene Ontology:
    Cellular Component: terminal button [IDA]
    postsynaptic membrane [IDA]
    synaptic vesicle [ISS][NAS]
    Biological Process: synaptic vesicle priming [NAS]
    intracellular signaling pathway [IEA]
    synaptic transmission [IMP][NAS]
    synaptic vesicle exocytosis [IMP][ISS]
    neurotransmitter secretion [NAS]
    Molecular Function: calmodulin binding [TAS]
    diacylglycerol binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMNTSQLQVT GDTEKKSQLL KKELKINTQE KLIFAENALK SQIKIKEQLR LQQQSTIYAS  60
   61 SLLSSSAAGS VRAPLLSQGH LNSIQHNMDF DLAKAQIPEM QPPMSKSPNG LDFSYLSYPS 120
  121 INTNESMISI KSEQQLCQSY NSEQHSDYII SDYMDKIATR ISLLETELKF AWRALDLLST 180
  181 EYGKIWIRLE KLENISIEQQ SVVGNLVDLI GASKKELQKV DIERMKVPLY QDEDQLLPLE 240
  241 MEDTLDIDIQ SSNRDFDKNL TFENHEKTFV TKHTQATKSE DLMNSAYAID SHPNFENIDF 300
  301 NGKNLDIGII KFGFEKGYEP KQKGNQSDFE AYKESRTKLY SDSDLMLYER QQFLANSARA 360
  361 ELMKEFLNGR RVLNEISASS GALSKSSEKD KNLVKPREPL LSEIDDTYVR RSTCELVSPS 420
  421 SNNFFQIAAS KTGEGGNQVL PIEDTGGTES PANINEVDES FYKNLNEAYR DNELSSEIFK 480
  481 VDALLHQSEA THDHISFIRN QSTSSPVLNN QRVNAITGTQ PLQTAKACLV TEPNQHLNKE 540
  541 PRKHRKKKHH TNEMDMINKL KCILAQAQST EIIKRDIEEL GSKLSDACVK QTETENKSDN 600
  601 HISTSYLKDD IRKMLNNVIQ TLLGEINKIK GLQSLSATQL SQLQNAVWSE ERFFQKISLV 660
  661 DKKLTLLLLN PLTVTEELQR LCISNTNEKF VLVIKKLKKN IDTLKKLVGS SLDDFKIDNS 720
  721 HANMTTFHSL NPSHNSNDSS FSAHLLRNNS NLDEQLKILE TQEIEIHRKK KIDEIVSGLS 780
  781 EETYTFNPDM EYKSQHSCTN STDNIIGFSK NIYNEDEYIK SLRKSLERHN SMIFLLHLQN 840
  841 PEKHKVLADI NDAQMDSNRA SLSPPPPAPT DTVYLNDAIN QITYQQRNGK SDSGLSSMSG 900
  901 WSANSQVSVG LQNYDPACNN ILENCSERLQ TYHSFPLAEN SNFHSFPLSH EQAQTTNQTE 960
  961 FVILEENLNY IYELSKNLPI CSAYENKSIF DMKYEICDSN EIGKFSTVDE MLEWDQLNEP1020
 1021 DKQNFSGKRL NSNLMPDLLT AQIPNSISKH NKNTSVNIEY VRQKENKGMD RRSIIEPNIY1080
 1081 NGKSEDQICR PCLTDKLVFY PSSNSITDHN SSHDFNCLSQ QDQTRIIKEF GSAHLNQDPT1140
 1141 NYLDYTSGTY SKAPPEVLTH ETNSSHLEFN HESESLFNSP NTSSYCKQKF VPGTSPAKPS1200
 1201 KVWKRLNTIL ADNLKLKRVS KFNRSLSLPG DVQSQGLQRQ PRGQAGSCPF IHKRSNLAGS1260
 1261 PVQLSKRIQK LPIRFIGRAK GVPFVRRSSS PDSAVSLDSA ADKRFSSEKG LKKKTISSKM1320
 1321 SGLMQKAKTY KRHSFVLRRG CNMSDSELEM PDFVSSGNDN SSISTREILL NQSIEVEDEQ1380
 1381 EDFNYKNRCD SKSVLGGSIE KLNGNLTNNL FPIVGDLKKI QSPLPLAVLT EIPSYKDEYS1440
 1441 NKSDSIKNSP IEMPKILLET ACNQELNLAH SDDDVDKNIL ANSAKDYVNA PTFSILKTVE1500
 1501 DASEPTMTPL HTTTTTNSSL NVTSALWVTQ QCLDLPNYPG WGSREDDDNR SQHSARTLSS1560
 1561 SRRQSTEDSI DTDDEYFYYE LRQLEEQEKQ RAHNSAIPSC ERQNDNDVLF SQIGQLLQND1620
 1621 VNGGDGFRHS NGCNDGEDAI IFSPSESVKL RMSEVFKELK SVVSLNPSVN NDATFEGVPI1680
 1681 VKPTYEKLET VSDLHSAWQD VNGDLQIAAS DIDSNEDLVG NKGRETPTYN KQRKLRRLKK1740
 1741 KTRDRKINIS KNATSSSSSC HSENECNTPL GQCTQKSVAE KDTNDISNKS EASSETSGPD1800
 1801 TPAELSDVDI SETENGLRAD DGQNIDNMRG NSGSLLKVNR KYLLQFDVDH SLINQPLETS1860
 1861 QYNTHMLENI TSASIPSQNR QIDSKTLMSQ SSHADGSQAV GNETAVGLSS SKWKLLKTLK1920
 1921 ERKIEEKNNQ DKIKEDEMIK DRDKNGGGPG EVGLRTNGHP GDNPFYSNID SMPDIRPRRK1980
 1981 SIPLVSELTM AATKRNAGLT SAVPRATLND EDLKMHVYKK ALQALIYPIS STTPHNFLLW2040
 2041 TATSPTYCYE CEGLLWGIAR QGVRCTECGV KCHEKCKDLL NADCLQRAAE KSSKHGAEDK2100
 2101 ANSIITAMKD RMKQREREKP EIFELIRAVF SVEEKSHAGH MKAVKQSVLD GTSKWSAKIA2160
 2161 ITVICAQGLI AKDKSGTSDP YVTVQVSKVK KRTRTMPQEL NPVWNEKFHF ECHNSSDRIK2220
 2221 VRVWDEDNDL KSKLRQKLTR ESDDFLGQTI IEVRTLSGEM DVWYNLEKRT DKSAVSGAIR2280
 2281 LHISVEIKGE EKVAPYHVQY TCLHENLFHY LCEENTGMVK LPTQKGDDAW KLYFDEIPEE2340
 2341 IVDEFSMRYG IENIYQAMTH FHCLSAKYLC PGVPAVMSTL LANINAYYAH TTASSAVSAS2400
 2401 DRFAASNFGK EKFVKLLDQL HNSLRIDLSM YRNNFPASSP EKLMDLKSTV DLLTSITFFR2460
 2461 MKVQELSSPP RASTVVKDCV KACLRSTYQF LFENCYELYN REFQVDPNEA KRAPDDHEPK2520
 2521 LDSVDFWHKL IALIVSVIDE DKNSYGTVLN QFPQELNIGQ LSASSMWHLF AVDMKYALEE2580
 2581 HEQHRLCKSS AYMNLHFRVK WLYSNYVKEV PPYKGAVPDY PAWFEPFVMQ WLNENDDVSL2640
 2641 EYLHGAFKRD KKDGFQKSSE HALFSNSVVD VFTQLTQCFD VVSKLECPDP EIWKRYMRRF2700
 2701 AKTIVKVLIA YADIVKLEFP EHMKDERIAC ILMNNIQQLR VQLEKMFESM GGDKLEEDAA2760
 2761 NILKELQQNL NSALDDLASQ FAISLEPRIT QSVRELGDML LSIKGGSGTL AAGNLAAQRN2820
 2821 AVAVEADEVL RPLMDLLDGS LTLYAQSCEK TVLKRLLKEL WKIVMRILEK TIVLPPMTDK2880
 2881 TMMFKHLTDN AKNLASNAKI EDMGRLFKSH MAGKQDVKSA LSGVMDISKE VEKNLSPKQC2940
 2941 AVLDVALDTI KQYFHAGGNG LKKTFLEKSP ELQSLRYALS LYTQMTDTLI KTFISSQVHE3000
 3001 VDLENSEESV GEISVQIDLF SHPGTGEHKV NVKVVAANDL KWQIPSGMFR PFVDINLIGP3060
 3061 HLQEKKRKFA TKSKSNNWSP KYNESFSFTI GNEEQLDFFE LHICVKDYCF ARDDRLVGVA3120
 3121 VIPLKDISEK GSVACWLPLM RRIEMDETGW TILRILSQRN NDEVAKEFVK LKSEIRQEPT3180
 3181 MGT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.88

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle