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Protein Overview: unc-13-PA, FBpp0...

General Information:
Name(s) found: FBpp0300962 [FlyBase]
unc-13-PA / FBpp0088305 [FlyBase]
Description(s) found:
Found 26 descriptions.
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  • type=protein; loc=4:complement(892119..892280,892346..892472,892538..892700,892753..892851,893840..894197,894261..894552,894620..894786,894872..895093,895829..896110,896169..896336,896740..896865,896922..897080,897143..897415,897496..897820,899477..899618,902469..902575,903587..903707,903769..903988,904193..904267,906386..906517,919019..923908,923963..923968); ID=FBpp0300962; name=unc-13-PD; parent=FBgn0025726,FBtr0308805; dbxref=FlyBase:FBpp0300962,FlyBase_Annotation_IDs:CG2999-PD,REFSEQ:NP_001245426,GB_protein:AFH06786; MD5=4060069865fbd9712bd8fff1a79c54b1; length=2871; release=r5.56; species=Dmel; [FlyBase]
  • The gene unc-13 is referred to in FlyBase by the symbol Dmel\unc-13 (CG2999, FBgn0025726). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 4:891551..925419. It has the cytological map location 102E5-102F1. Based on sequence similarity, it is predicted to have molecular function</span>: diacylglycerol binding. There is experimental evidence that it is involved in the biological process</span>: synaptic transmission; synaptic vesicle exocytosis. 7 alleles are reported. The phenotype of these alleles is annotated with: synaptic vesicle. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2871 amino acids

    Gene Ontology:
    Cellular Component: terminal button [IDA]
    postsynaptic membrane [IDA]
    synaptic vesicle [ISS][NAS]
    Biological Process: synaptic vesicle priming [NAS]
    intracellular signaling pathway [IEA]
    synaptic transmission [IMP][NAS]
    synaptic vesicle exocytosis [IMP][ISS]
    neurotransmitter secretion [NAS]
    Molecular Function: calmodulin binding [TAS]
    diacylglycerol binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTHYVRHDYF HNTQNGALSS DTSRISYSQI SYETQPSREY FSESYALSNQ GPEECSRVSH  60
   61 LNSDTVLTTV DNSNNSYGYD YLECYGANIQ CDPEEDSVDN WNENTSVVAD QYGLGHNNLN 120
  121 CTSSKLLPKL PNIENGRGSS NACAPQMDVK FNTKGMCIKI DHSYGVCMAK AHDFVGRLSP 180
  181 SDYQNILGNN LNGYAGCAYS STFLDNAMSS APLRVLPQSP RCSSYLGRNI IGFNADAAQR 240
  241 DGRGFDTDQT DAMGSESSTY EVYEKMQRPY TSMLPLDYSD YQEGCYNTDN LSTYSDTPPS 300
  301 NNTQLKRQMQ RKISLMMAMT TASVIASGEI RVPVHSKQSK KSTEIQTDSI IGNTISTNAA 360
  361 ARDLDRCLAT ESCEVIVDTR DSGSVTSFPS SAVTAITKTR KLPKVLPTPL CKSSRHPITI 420
  421 ATDALSSSYT SDPLPEKSHR PKQLPKLPIS LPQSNDRASL NSNWATPPAP DALPFNSFDH 480
  481 KSASSPTPTT TITKDTETTS YLVETDFIGA RHNALYQYDS KEPNIVFSDK SVEAEHSPTW 540
  541 TPLSPIQSKQ SPCPPVALPS NIMQNVSLTC HLPEIEATRS DIEREPESSS IEPILEIEKL 600
  601 ADPYSGPGSA LFNISEYLKP YTLNKPILSE EKKNHIANAA STSTTTPLNI TSDDEFSSYS 660
  661 NKWTSTCVNF QPLDVESSLN ISLKVNAGTN QAELLMTPLK SSTPLFISSN GTSDNFNLRK 720
  721 SSPPDSAFTT TVNVNSFETV LVSGSQTASP SPSNLKSPPS IAPLLSYSDY MKQFELPELP 780
  781 QPIMDLSEND TATQSDSFNV INNTLTNADN LNSYNQMDVE SKSSLQLPSY SSESFDPCSV 840
  841 PSFSIKNKEY KIVEKLDSLS NVESVESPKT LVSPVNPLNC SKLLPGTESI VSNDVAFDDT 900
  901 FYDSFNVDIK ELTAFVDHVA PEDGLYNFPN DKTSVEFSFD KTEDTIDMNQ NLSSGECGYY 960
  961 KPSQAQQKAS VVASAASSVL DGISKGLKGG LDGVFSGVSS TVDVTQSNPS SKRGFSFNLA1020
 1021 SKIVPSVGGL LTSTSSTSIK QTGSETNPTL ILISPENVSS RNSNYIPTTS PSCTQKNGEE1080
 1081 NLYSATVHNK STKSNSYYNE VGEISSTLVR NVCDSYDNSY DEMILTNEMV NIGMLDSESE1140
 1141 FGLIENSYSY QVPDNEQIDS VNSYNNKTQN VTNNGIEKAN TKNKPVPLHD PPTKKASTVG1200
 1201 MFGSILGKAA AAVQSATQAV NQSASSVASV VAQKPTIVPR TNNVLLLSSV CSPNEIKRNS1260
 1261 SSVEFDSEYG YQMPDVESLS SHYANTGGDY DNSNMKIHEF GTYADDRPYA DYHTNGNQSQ1320
 1321 FKEEAVIPGE PEVINTNILP IGPQATGKKL PTVNGKSALL IKQMPTEVYD DESDTDELDV1380
 1381 SPSTGKVPSY SIYSEQEDYY MDLQQTTPSI QPNGFYEQVN NGYDYREDYF NEEDEYKYLE1440
 1441 QQREQEEHNQ PKNKKYLKQA KISKIQPPSL DFIDVGQDDD FIYDNYHSED DSGNYLEGSS1500
 1501 SGSVGPIEGS IIKVDSNIEA SFASLNKKSD SFTPTNDSLQ KHDTVIGEST TKLTRLRTEK1560
 1561 MCPDVDEEDE NLSDHVSDLT DLSKLISQKK KTLLRGETEE VVGGHMQVLR QTEITARQRW1620
 1621 HWAYNKIIMQ LNNGGGPGEV GLRTNGHPGD NPFYSNIDSM PDIRPRRKSI PLVSELTMAA1680
 1681 TKRNAGLTSA VPRATLNDED LKMHVYKKAL QALIYPISST TPHNFLLWTA TSPTYCYECE1740
 1741 GLLWGIARQG VRCTECGVKC HEKCKDLLNA DCLQRAAEKS SKHGAEDKAN SIITAMKDRM1800
 1801 KQREREKPEI FELIRMTFGV DPDTHIDSLE QAEHATVEGT SKWSCKLTIT VICAQGLIAK1860
 1861 DKSGTSDPYV TVQVSKVKKR TRTMPQELNP VWNEKFHFEC HNSSDRIKVR VWDEDNDLKS1920
 1921 KLRQKLTRES DDFLGQTIIE VRTLSGEMDV WYNLEKRTDK SAVSGAIRLH ISVEIKGEEK1980
 1981 VAPYHVQYTC LHENLFHYLC EENTGMVKLP TQKGDDAWKL YFDEIPEEIV DEFSMRYGIE2040
 2041 NIYQAMTHFH CLSAKYLCPG VPAVMSTLLA NINAYYAHTT ASSAVSASDR FAASNFGKEK2100
 2101 FVKLLDQLHN SLRIDLSMYR NNFPASSPEK LMDLKSTVDL LTSITFFRMK VQELSSPPRA2160
 2161 STVVKDCVKA CLRSTYQFLF ENCYELYNRE FQVDPNEAKR APDDHEPKLD SVDFWHKLIA2220
 2221 LIVSVIDEDK NSYGTVLNQF PQELNIGQLS ASSMWHLFAV DMKYALEEHE QHRLCKSSAY2280
 2281 MNLHFRVKWL YSNYVKEVPP YKGAVPDYPA WFEPFVMQWL NENDDVSLEY LHGAFKRDKK2340
 2341 DGFQKSSEHA LFSNSVVDVF TQLTQCFDVV SKLECPDPEI WKRYMRRFAK TIVKVLIAYA2400
 2401 DIVKLEFPEH MKDERIACIL MNNIQQLRVQ LEKMFESMGG DKLEEDAANI LKELQQNLNS2460
 2461 ALDDLASQFA ISLEPRITQS VRELGDMLLS IKGGSGTLAA GNLAAQRNAV AVEADEVLRP2520
 2521 LMDLLDGSLT LYAQSCEKTV LKRLLKELWK IVMRILEKTI VLPPMTDKTM MFKHLTDNAK2580
 2581 NLASNAKIED MGRLFKSHMA GKQDVKSALS GVMDISKEVE KNLSPKQCAV LDVALDTIKQ2640
 2641 YFHAGGNGLK KTFLEKSPEL QSLRYALSLY TQMTDTLIKT FISSQVHEVD LENSEESVGE2700
 2701 ISVQIDLFSH PGTGEHKVNV KVVAANDLKW QIPSGMFRPF VDINLIGPHL QEKKRKFATK2760
 2761 SKSNNWSPKY NESFSFTIGN EEQLDFFELH ICVKDYCFAR DDRLVGVAVI PLKDISEKGS2820
 2821 VACWLPLMRR IEMDETGWTI LRILSQRNND EVAKEFVKLK SEIRQEPTMG T

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle