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Protein Overview: Ephrin-PC, Ephri...

General Information:
Name(s) found: Ephrin-PC / FBpp0088146 [FlyBase]
Ephrin-PB / FBpp0088145 [FlyBase]
Ephrin-PA / FBpp0088144 [FlyBase]
Description(s) found:
Found 59 descriptions.
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  • The gene Ephrin is referred to in FlyBase by the symbol Dmel\Ephrin (CG1862, FBgn0040324). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 4:592383..598159. It has the cytological map location 102C5-102C6. There is experimental evidence that it has the molecular function</span>: ephrin receptor binding. There is experimental evidence that it is involved in the biological process</span>: axon guidance; mushroom body development. 15 alleles are reported. The phenotypes of these alleles are annotated with: commissure; eye; longitudinal connective; mushroom body medial lobe; embryonic central nervous system; mushroom body vertical lobe; embryonic neuron; mushroom body alpha-lobe. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • The gene Ephrin is referred to in FlyBase by the symbol Dmel\Ephrin (CG1862, FBgn0040324). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 4:592383..598159. It has the cytological map location 102C5-102C6. There is experimental evidence that it has the molecular function</span>: ephrin receptor binding. There is experimental evidence that it is involved in the biological process</span>: axon guidance; mushroom body development. 15 alleles are reported. The phenotypes of these alleles are annotated with: commissure; eye; longitudinal connective; mushroom body medial lobe; embryonic central nervous system; mushroom body vertical lobe; embryonic neuron; mushroom body alpha-lobe. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • The gene Ephrin is referred to in FlyBase by the symbol Dmel\Ephrin (CG1862, FBgn0040324). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 4:592383..598159. It has the cytological map location 102C5-102C6. There is experimental evidence that it has the molecular function</span>: ephrin receptor binding. There is experimental evidence that it is involved in the biological process</span>: axon guidance; mushroom body development. 15 alleles are reported. The phenotypes of these alleles are annotated with: commissure; eye; longitudinal connective; mushroom body medial lobe; embryonic central nervous system; mushroom body vertical lobe; embryonic neuron; mushroom body alpha-lobe. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 652 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [IDA]
    Biological Process: mushroom body development [IMP]
    axon guidance [IMP]
    Molecular Function: ephrin receptor binding [IDA][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQERSKQLRL TVSWTQSKSQ IHDSCQRRSM LACKRRLTTS KVLEDSHPPV AFPNCKSHRH  60
   61 QQQKEKHKVQ LYSGKPLSIK LYVPGSIESI PKIRHKALTT TNKQQPAMHR KSKSKSKFQG 120
  121 FNNLKPLYSP SKRQPPEKHS SVLVEAGIES KASRHFVGKK RIKNRNCLLS SPQPSPMRCK 180
  181 MMIPFPKFGA TSFVTLLTLI CMETVLLSTM SSCAKTFYMH WNTSNSIFRI DNTDHIIDVN 240
  241 KGNLAFEFDQ VHIICPVYEP GTFENETEKY IIYNVSKVEY ETCRITNADP RVIAICDKPQ 300
  301 KLMFFTITFR PFTPQPGGLE FLPGNDYYFI STSSKDDLYR RIGGRCSTNN MKVVFKVCCA 360
  361 PEDNNKTTAL SNSKSVTDTG GAINVNIANN DESHVNSHGN NIAIGTNIGI NGGQIIGGPQ 420
  421 SAGIPINPLS GNNNINGIPT TINSNIDQFN RIPIQPNIIG NHVGTNAVGT GIVGGGGIIL 480
  481 TPGHAHGNIN MLQPGRGGIN GAYPGHHHIQ TGIRINNVPT QHNYPSHKGN ANSNINGNDD 540
  541 HHHYNKHPNE VVKNEELTYN SGAATSDGNI FALWIWILSI FPLLSIQSCH LSSYWISASF 600
  601 LVSTIAILGI HYLIQITLQT TVQRYSPGMV EITATSMNGM FDQNAGTIEY DR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..210] deduced N/A No confident structure predictions are available.
    2 View Details [211..336] PSI-BLAST 45.522879 Ephrin-b2 ectodomain
    3 View Details [337..555] PSI-BLAST 11.69897 No description for 1y0fB was found.
    4 View Details [556..652] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • ephrin receptor binding
    		•  2.36859280211986 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.36323002598215 bayes_pls_golite062009
  • transporter activity
    		•  2.349332206525 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.33073133834369 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.32480642400158 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.29776380543181 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.29241843776882 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  2.06651640066545 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  1.62698854419438 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  1.56305555927578 bayes_pls_golite062009
  • binding
    		•  0.988564914693201 bayes_pls_golite062009
  • transmembrane-ephrin receptor activity
    		•  0.986157912102199 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  0.63330965564582 bayes_pls_golite062009
  • ephrin receptor activity
    		•  0.605684209141979 bayes_pls_golite062009
  • receptor activity
    		•  0.536491030734287 bayes_pls_golite062009
  • receptor binding
    		•  0.4653316685403 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.416025501184058 bayes_pls_golite062009
  • protein binding
    		•  0.31459442397123 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.12460560872441 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle