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Protein Overview: FBpp0311396, Thd...

General Information:
Name(s) found: FBpp0311396 [FlyBase]
FBpp0305856 [FlyBase]
Thd1-PA / FBpp0088175 [FlyBase]
Description(s) found:
Found 34 descriptions.
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  • type=protein; loc=4:complement(566289..568769,569885..570247,570340..570499,571380..572006,572617..574202); ID=FBpp0311396; name=Thd1-PC; parent=FBgn0026869,FBtr0345197; dbxref=FlyBase:FBpp0311396,FlyBase_Annotation_IDs:CG1981-PC; MD5=606d7cf8527a9ca7ea0f48c7f85a57b2; length=1738; release=r5.56; species=Dmel; [FlyBase]
  • type=protein; loc=4:complement(566289..568769,569885..570247,570340..570499,571380..572006,572617..574202); ID=FBpp0305856; name=Thd1-PB; parent=FBgn0026869,FBtr0333706; dbxref=REFSEQ:NP_001259060,GB_protein:AGB96550,FlyBase:FBpp0305856,FlyBase_Annotation_IDs:CG1981-PB; MD5=606d7cf8527a9ca7ea0f48c7f85a57b2; length=1738; release=r5.56; species=Dmel; [FlyBase]
  • The gene Thd1 is referred to in FlyBase by the symbol Dmel\Thd1 (CG1981, FBgn0026869). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 4:565889..578440. It has the cytological map location 102C5. There is experimental evidence that it has the molecular function</span>: pyrimidine-specific mismatch base pair DNA N-glycosylase activity; double-stranded DNA binding. There is experimental evidence that it is involved in the biological process</span>: mismatch repair; cellular response to DNA damage stimulus. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1738 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: nucleotide-excision repair [NAS]
    mismatch repair [IDA]
    response to DNA damage stimulus [IMP]
    Molecular Function: pyrimidine-specific mismatch base pair DNA N-glycosylase activity [IDA][NAS]
    double-stranded DNA binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQEESGSTPL LSSSFSYTPT VAPLVLKIAL IQAARSFAAS KYTIKVLLSL NLALSEQAIV  60
   61 QKAVKPICTV MASEVDASSG PEDGTVPTLM SLTPYITNLE HGNNESGKYV SGLPNNRKRQ 120
  121 KLSILEHNTI QNNDVDNTEV EPNMDPKSKM SDTKSNKYSE MEKHLNDNSK IVIEGTISIG 180
  181 NSKRKSPEKL VPYDNDCYMP PEQALVTSVE LVVPAPQTHS SNTPGRQSEE PNLSTLGESS 240
  241 TTPSSTIDNK LQYSTAGLYN STSSTSILAN DKIVGCANDS SNLNLRIPTK LVVTTASGDI 300
  301 LIDDRRASLW TPHHDESGQR QQRTGTASSD TKQEPMNVSS ELSYHHQNRH SELLLQIEKE 360
  361 SSGSFLQASP IPLQDNHNNA ASGQFGQTEE TSNIDSQSHN NFYAQMMQPQ HLLHNQHQQS 420
  421 MHEHSPRHQQ PASYSGYITH YQNPPMFGAH QSEHHQRLNQ QQQPLQHLLD CHGHLEQSTP 480
  481 ISQQNQHHLS QQIHQHQHQQ THQRLPLREN YHDIIMDDFH EEPSHAFKLT LSPSNTKPEN 540
  541 QDDGYETSAG DVLTPNSHSS STHSITPQHQ MQHSNIVLMT QNQKKSDDLQ LTKVTLSGEA 600
  601 HTDPNACSSN SSQGQVLASQ SHLELSEGTR CSSHASVVDP YSFMGEELHM HSPSHRHLDA 660
  661 VTTGPGRYGI LVSNDTPECL SREMYRHSQQ STTVLEQTDS SSCGINFKPM PKKRGRKKKL 720
  721 VAVNADTSQM TTPVDQQKVS AGRADCEDGG GDQAAKPKER KKHDRFNGMS EEEVIKRTIP 780
  781 DHLCDNLDIV IVGINPGLFA AYKGHHYAGP GNHFWKCLYL AGLTQEQMSA DEDHKLIKQG 840
  841 IGFTNMVARA TKGSADLTRK EIKEGSRILL EKLQRFRPKV AVFNGKLIFE VFSGKKEFHF 900
  901 GRQPDRVDGT DTFIWVMPSS SARCAQLPRA ADKVPFYAAL KKFRDFLNGQ IPHIDESECV 960
  961 FTDQRIRLCS AQQQVDIVGK INKTHQPPLG DHPSSLTVVS NCSGPIAGDA ECGIVAEESD1020
 1021 QVQSEKMIPQ MDPTVPSSSN ATDGKSFSYT AENTPLLPVS NHNPSINENN YLSVMGSQQP1080
 1081 LSQQPLEKKK RGRPKKIKGQ DIIDHSVGGK ASIAGQHIPS HDFNNILNLS VMSGGGTIET1140
 1141 PKKKRGRPKK LKPAIDNIMT VKQLQHGNNN LNTTAGLSAS SMHPISMEHI AASPQSSHQM1200
 1201 PPSLYNTPPP SHLLYTASAS PMASPALNCN YTQVHGHGTP PVGQVASVAQ GSSPVIDTQN1260
 1261 DHLAQQKQSH HGNLGAGLDM RDHPHLGETP PPSSPNMCST VDFDPPDEHS GSQVGSRVQN1320
 1321 KAVELDHQHP QIMEKVQYDS PVPNTEANPA HPHENYQQWL SPHPHQSNQP AQKLTHRQQH1380
 1381 PPMHHFHQEQ TENWQRYEEQ NSNPYMVISA HHQHLSPRLG NQTHQNSSPS GHISSDVAHK1440
 1441 SLCGLESLVD QIPAIREQDC SNIPLATVAA AAAAVESRIL SLQHQHQHPL QPHQQNQQNQ1500
 1501 QQQLKQCKQE NSAHRESCRP TSENSNVSNS NFSVSSLAAS ASSARTDNAI YGNGETKGNN1560
 1561 ESSHHNSCDT NIDYPIHNQS AYHHTPHLIG SALGTNVNNS EPNLHTISHP HPPHPHPHSM1620
 1621 YVDQAHHMAH IPSVNVNSMY GPAYGSHPQH TTGEYPGTHG HYSLGGSVQT AVPTSSATLH1680
 1681 VPSPNYPFGH HPYGHTPPQA NYPSYTHPHT HHHHSHPSHH LTVFDHLKPS DISGYGGF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..132] deduced N/A No confident structure predictions are available.
    2 View Details [133..280] deduced N/A No confident structure predictions are available.
    3 View Details [281..535] deduced N/A No confident structure predictions are available.
    4 View Details [536..775] deduced N/A No confident structure predictions are available.
    5 View Details [776..1045] PSI-BLAST 93.69897 Crystal Structure of SUMO1-conjugated thymine DNA glycosylase
    6 View Details [1046..1228] MSA 1.060984 View MSA. No confident structure predictions are available.
    7 View Details [1229..1294] deduced N/A No confident structure predictions are available.
    8 View Details [1295..1482] MSA 2.070996 View MSA. No confident structure predictions are available.
    9 View Details [1483..1738] FFAS03 0.95 No description for 2jrnA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • DNA N-glycosylase activity
    		•  4.49770781621045 bayes_pls_golite062009
  • hydrolase activity, hydrolyzing N-glycosyl compounds
    		•  4.14479139843076 bayes_pls_golite062009
  • uracil DNA N-glycosylase activity
    		•  3.90350764950421 bayes_pls_golite062009
  • hydrolase activity, acting on glycosyl bonds
    		•  2.96262005834299 bayes_pls_golite062009
  • catalytic activity
    		•  1.96155289609929 bayes_pls_golite062009
  • hydrolase activity
    		•  1.80710505371922 bayes_pls_golite062009
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.85

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle