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Protein Overview: CaMKI-PH

General Information:
Name(s) found: CaMKI-PH / FBpp0088132 [FlyBase]
Description(s) found:
Found 27 descriptions.
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  • The gene Calcium/calmodulin-dependent protein kinase I is referred to in FlyBase by the symbol Dmel\CaMKI (CG1495, FBgn0016126). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 4:466120..474566. It has the cytological map location 102C1. Based on sequence similarity, it is predicted to have molecular function</span>: calmodulin-dependent protein kinase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: protein amino acid phosphorylation. 6 alleles are reported. No phenotypic data is available. It has 7 annotated transcripts and 7 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 284 amino acids

    Gene Ontology:
    Cellular Component: cytosol [ISS]
    Biological Process: protein amino acid phosphorylation [IEA][ISS][NAS]
    Molecular Function: ATP binding [IEA]
    calmodulin binding [TAS]
    calmodulin-dependent protein kinase activity [ISS]
    protein serine/threonine kinase activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELVTGGELF DRIVEKGSYT EKDASHLIRQ ILEAVDYMHE QGVVHRDLKP ENLLYYSPDD  60
   61 DSKIMISDFG LSKMEDSGIM ATACGTPGYV APEVLAQKPY GKAVDVWSIG VISYILLCGY 120
  121 PPFYDENDAN LFAQILKGDF EFDSPYWDEI SESAKHFIKN LMCVTVEKRY TCKQALGHAW 180
  181 ISGNEASSRN IHGTVSEQLK KNFAKSRWKQ AYYAATVIRQ MQRMALNSNS NANFDSSNSS 240
  241 NQDSTTPTAA TGAWTSNVLS SQQSVQSHAQ EMNKSGGSTN AASQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..228] PSI-BLAST 71.522879 CALMODULIN-DEPENDENT PROTEIN KINASE FROM RAT
    2 View Details [229..284] PSI-BLAST 9.221849 Regulatory apparatus of Calcium Dependent protein kinase from Arabidopsis thaliana

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • protein kinase activity
    		•  5.17195961442593 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • binding
    		•  1.51590581981342 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • protein binding
    		•  1.36269611679417 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.684204466593894 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.196560862858137 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle