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Protein Overview: FBpp0311451, Hcf...

General Information:
Name(s) found: FBpp0311451 [FlyBase]
Hcf-PA / FBpp0088195 [FlyBase]
Hcf-PB / FBpp0088194 [FlyBase]
Description(s) found:
Found 59 descriptions.
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  • type=protein; loc=4:join(381317..381632,382930..383239,383297..383508,383572..383760,384120..384265,384494..385567,386300..387388,390133..390370,390436..390590,391717..391983,392439..392802,392876..393018); ID=FBpp0311451; name=Hcf-PG; parent=FBgn0039904,FBtr0345284; dbxref=FlyBase:FBpp0311451,FlyBase_Annotation_IDs:CG1710-PG; MD5=ace81599602c8f0ae6a445a5e359f4a0; length=1500; release=r5.56; species=Dmel; [FlyBase]
  • The gene Host cell factor is referred to in FlyBase by the symbol Dmel\Hcf (CG1710, FBgn0039904). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 4:380578..395610. It has the cytological map location 102B5-102B6. Based on sequence similarity, it is predicted to have molecular function</span>: transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: regulation of histone acetylation. 4 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • The gene Host cell factor is referred to in FlyBase by the symbol Dmel\Hcf (CG1710, FBgn0039904). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 4:380578..395610. It has the cytological map location 102B5-102B6. Based on sequence similarity, it is predicted to have molecular function</span>: transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: regulation of histone acetylation. 4 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1500 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][ISS]
    H4/H2A histone acetyltransferase complex [IDA]
    Biological Process: regulation of histone acetylation [IDA]
    Molecular Function: transcription factor activity [ISS]
    transcription coactivator activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEGSDFVDPA FSSGERISAS DLNSEHIIQA ENHSFANRIS MDMDVPDGHQ LDSNLTGFRW  60
   61 KRVLNPTGPQ PRPRHGHRAI NIKELMVVFG GGNEGIVDEL HVYNTVTNQW YVPVLKGDVP 120
  121 NGCAAYGFVV EGTRMFVFGG MIEYGKYSNE LYELQATKWE WRKMYPESPD SGLSPCPRLG 180
  181 HSFTMVGEKI FLFGGLANES DDPKNNIPKY LNDLYILDTR GVHSHNGKWI VPKTYGDSPP 240
  241 PRESHTGISF ATKSNGNLNL LIYGGMSGCR LGDLWLLETD SMTWSKPKTS GEAPLPRSLH 300
  301 SSTMIGNKMY VFGGWVPLVI NDSKSTTERE WKCTNTLAVL DLETMTWENV TLDTVEENVP 360
  361 RARAGHCAVG IQSRLYVWSG RDGYRKAWNN QVCCKDLWYL EVSKPLYAVK VALVRASTHA 420
  421 LELSWTATTF AAAYVLQIQK IEQPLNTSSK LLSNNIVQQG TPTSAETSGI NISANRSGSA 480
  481 LGLGVEATST VLKLEKESLQ LSGCQPETNV QPSVNDLLQS MSQPSSPASR ADKDPLSSGG 540
  541 GTTFNLSTSV ASVHPQISVI SSTAAVTGND TASPSGAINS ILQKFRPVVT AVRTSTTTAV 600
  601 SIATSTSDPL SVRVPSTMSA NVVLSSSSST LRIVPSVTAS HSLRIASSQA SGNNCRSSSA 660
  661 INILKTALPN VAVQSQPTSS TTTSIGGKQY FIQKPLTLAP NVQLQFVKTS GGMTVQTLPK 720
  721 VNFTASKGTP PHGISIANPH LASGITQIQG STVPGSQIQK PIVSGNVLKL VSPHTMAGGK 780
  781 LIMKNSNILQ MGKVTPNVMG GKPAFVITNK QGTPLGNQQI IIVTTGGNVR SVPTSTVMTS 840
  841 AGGSASGTNI VSIVNSTSTT PSPLQALSGQ KTLISNQSGV KMLRNISSVQ ASSSMAFGQK 900
  901 QSGTPIHQKT ALYIGGKAVT VMSTNTSMAA SGNKVMVLPG TSSNNSPATT TALSARKSFV 960
  961 FNAGGSPRTV TLATKSINAK SIPQSQPVTE TNNHSVATIK DTDPMDDIIE QLDGAGDLLK1020
 1021 LSESEGQHGS EENENNGENA TSSSASALFT GGDTAGPSRA QNPIVMEHPV DIIEDVSGVS1080
 1081 STTDVNETAI VSGDTIESLK MSEKENDDVK SMGEKSILSD DCHQPTTSET EAATILTTIK1140
 1141 SAEALVLETA EIRKDHTGCT IGSLKENQDE NKKFKQRQES SPSQNIHQFQ NVDGSQLEAL1200
 1201 ASAALLQAAT SDTTALALKE LIERPESETN TRSSNIAEIQ QNNVQSTLAV VVPNTSQNEN1260
 1261 QKWHTVGVFK DLSHTVTSYI DSNCISDSFF DGIDVDNLPD FSKFPRTNLE PGTAYRFRLS1320
 1321 AINSCGRGEW GEISSFKTCL PGFPGAPSAI KISKDVKEGA HLTWEPPPAQ KTKEIIEYSV1380
 1381 YLAVKPTAKD KALSTPQLAF VRVYVGAANQ CTVPNASLSN AHVDCSNKPA IIFRIAARNQ1440
 1441 KGYGPATQVR WLQDPAAAKQ HTPTVTPNLK RGPEKSTIGS SNIANTFCSP HKRGRNGLHD1500
 1501

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..390] PSI-BLAST 48.0 Crystal structure of the Kelch domain of human Keap1
    2 View Details [391..452] deduced N/A No confident structure predictions are available.
    3 View Details [453..531] deduced N/A No confident structure predictions are available.
    4 View Details [532..590] deduced N/A No confident structure predictions are available.
    5 View Details [591..733] deduced N/A No confident structure predictions are available.
    6 View Details [734..814] deduced N/A No confident structure predictions are available.
    7 View Details [815..940] MSA 1.189986 View MSA. No confident structure predictions are available.
    8 View Details [941..1180] deduced N/A No confident structure predictions are available.
    9 View Details [1181..1354] FFAS03 1.03 No description for 1zlgA was found.
    10 View Details [1355..1500] PSI-BLAST 6.045757 Solution structure of C-terminal fibronectin type III domain of mouse 1700129L13Rik protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.
    10
    Term Confidence Notes
  • binding
    		•  3.12471204223368 bayes_pls_golite062009
  • protein binding
    		•  2.19476891312192 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.46679592932696 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.46015530818566 bayes_pls_golite062009
  • DNA binding
    		•  1.31479811147611 bayes_pls_golite062009
  • receptor activity
    		•  1.09869678752178 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.973029129105242 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.75571850752672 bayes_pls_golite062009
  • interleukin-6 receptor activity
    		•  0.718898152168871 bayes_pls_golite062009
  • interleukin-6 binding
    		•  0.718898152168871 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor activity
    		•  0.69178447295342 bayes_pls_golite062009
  • transcription factor activity
    		•  0.663380108686544 bayes_pls_golite062009
  • cytokine binding
    		•  0.615170922526876 bayes_pls_golite062009
  • protein kinase activity
    		•  0.336349457621575 bayes_pls_golite062009
  • cytokine receptor activity
    		•  0.320890688774472 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.256712571555851 bayes_pls_golite062009
  • signal transducer activity
    		•  0.256712571555851 bayes_pls_golite062009
  • transcription activator activity
    		•  0.221147458438061 bayes_pls_golite062009
  • structural molecule activity
    		•  0.18965275490219 bayes_pls_golite062009
  • transcription factor binding
    		•  0.183613617278749 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.116377273702831 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.0173897395472495 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle