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Protein Overview: ttk-PC, ttk-PF, ...

General Information:
Name(s) found: FBpp0292320 [FlyBase]
ttk-PD / FBpp0085191 [FlyBase]
ttk-PC / FBpp0085189 [FlyBase]
ttk-PF / FBpp0085187 [FlyBase]
Description(s) found:
Found 61 descriptions.
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  • type=protein; loc=3R:join(27553013..27553156,27553344..27553976,27554114..27554201,27555354..27556420); ID=FBpp0292320; name=ttk-PH; parent=FBgn0003870,FBtr0303228; dbxref=FlyBase:FBpp0292320,FlyBase_Annotation_IDs:CG1856-PH,REFSEQ:NP_001189330,GB_protein:ADV37420; MD5=fdad7181736a5c101ed839f4eb38fe42; length=643; release=r5.56; species=Dmel; [FlyBase]
  • The gene tramtrack is referred to in FlyBase by the symbol Dmel\ttk (CG1856, FBgn0003870). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:27539606..27561114. It has the cytological map location 100D1. There is experimental evidence that it has the molecular function</span>: protein binding; specific transcriptional repressor activity; chromatin binding; protein homodimerization activity. There is experimental evidence that it is involved in the biological process</span>: inter-male aggressive behavior; startle response; brain morphogenesis; dendrite morphogenesis; neuron development; ovarian follicle cell development; negative regulation of transcription, DNA-dependent; dorsal appendage formation; locomotion involved in locomotory behavior. 152 alleles are reported. The phenotypes of these alleles are annotated with 70 unique terms, many of which group under: peripheral nervous system; nervous system; external compound sense organ; adult segment; embryonic nervous system; multi-cell-component structure; adult mesothoracic segment; embryonic glial cell; imaginal precursor; larval abdominal segment 5. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
  • The gene tramtrack is referred to in FlyBase by the symbol Dmel\ttk (CG1856, FBgn0003870). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:27539606..27561114. It has the cytological map location 100D1. There is experimental evidence that it has the molecular function</span>: protein binding; specific transcriptional repressor activity; chromatin binding; protein homodimerization activity. There is experimental evidence that it is involved in the biological process</span>: inter-male aggressive behavior; startle response; brain morphogenesis; dendrite morphogenesis; neuron development; ovarian follicle cell development; negative regulation of transcription, DNA-dependent; dorsal appendage formation; locomotion involved in locomotory behavior. 152 alleles are reported. The phenotypes of these alleles are annotated with 70 unique terms, many of which group under: peripheral nervous system; nervous system; external compound sense organ; adult segment; embryonic nervous system; multi-cell-component structure; adult mesothoracic segment; embryonic glial cell; imaginal precursor; larval abdominal segment 5. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
  • The gene tramtrack is referred to in FlyBase by the symbol Dmel\ttk (CG1856, FBgn0003870). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:27539606..27561114. It has the cytological map location 100D1. There is experimental evidence that it has the molecular function</span>: protein binding; specific transcriptional repressor activity; chromatin binding; protein homodimerization activity. There is experimental evidence that it is involved in the biological process</span>: inter-male aggressive behavior; startle response; brain morphogenesis; dendrite morphogenesis; neuron development; ovarian follicle cell development; negative regulation of transcription, DNA-dependent; dorsal appendage formation; locomotion involved in locomotory behavior. 152 alleles are reported. The phenotypes of these alleles are annotated with 70 unique terms, many of which group under: peripheral nervous system; nervous system; external compound sense organ; adult segment; embryonic nervous system; multi-cell-component structure; adult mesothoracic segment; embryonic glial cell; imaginal precursor; larval abdominal segment 5. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 643 amino acids

    Gene Ontology:
    Cellular Component: nucleus [NAS]
    polytene chromosome [IDA]
    Biological Process: regulation of cell shape [IMP]
    R7 cell development [TAS]
    peripheral nervous system development [TAS]
    dorsal appendage formation [IMP]
    brain morphogenesis [IMP]
    neuron development [IMP]
    inter-male aggressive behavior [IMP]
    regulation of transcription from RNA polymerase II promoter [NAS]
    dendrite morphogenesis [IMP]
    negative regulation of transcription from RNA polymerase II promoter [NAS]
    locomotion involved in locomotory behavior [IMP]
    negative regulation of transcription, DNA-dependent [IDA]
    startle response [IMP]
    ovarian follicle cell development [IMP]
    cell fate determination [TAS]
    Molecular Function: DNA binding [IEA]
    zinc ion binding [IEA]
    protein homodimerization activity [IPI]
    protein binding [IPI]
    specific RNA polymerase II transcription factor activity [NAS]
    chromatin binding [IDA]
    transcription repressor activity [NAS]
    specific transcriptional repressor activity [IMP]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKMASQRFCL RWNNHQSNLL SVFDQLLHAE TFTDVTLAVE GQHLKAHKMV LSACSPYFNT  60
   61 LFVSHPEKHP IVILKDVPYS DMKSLLDFMY RGEVSVDQER LTAFLRVAES LRIKGLTEVN 120
  121 DDKPSPAAAA AGAGATGSES TATTPQLQRI QPYLVPQRNR SQAGGLLASA ANAGNTPTLP 180
  181 VQPSLLSSAL MPKRKRGRPR KLSGSSNGTG NDYDDFDREN MMNDSSDLGN GKMCNESYSG 240
  241 NDDGSDDNQP NAGHTDDLNE SRDSLPSKRS KNSKDHRVVS HHEDNSTSDG NDSDGEGLDT 300
  301 SYMEPQLMLD EYDEPVEFKY NPLTDNSSPT QDHTDGSHLN EQARQQAFLI AAQRKHQVET 360
  361 AAAAAASGIK LNIIGMAAGG AQVKSMVSIP KLTPIGKVNA ASTPLVSPAG SFSTATVKPR 420
  421 VQKRPKLGKQ NGDVKPAVFS SQEYLDIYNS NDGFKLKAAG LSGSTPNLSA GLGTPSVKTK 480
  481 LNLSSNVGEG EAEGSVRDYC TKEGEHTYRC KVCSRVYTHI SNFCRHYVTS HKRNVKVYPC 540
  541 PFCFKEFTRK DNMTAHVKII HKIENPSTAL ATVAAANLAG QPLGVSGAST PPPPDLSGQN 600
  601 SNQSLPATSN ALSTSSSSST SSSSGSLGPL TTSAPPAPAA AAQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..126] PSI-BLAST 18.09691 No description for 2ihcA was found.
    2 View Details [127..225] MSA 1.360996 View MSA. No confident structure predictions are available.
    3 View Details [226..500] PSI-BLAST 50.09691 No description for 2i13A was found.
    4 View Details [501..566] PSI-BLAST 4.522879 Tramtrack protein (two zinc-finger peptide)
    5 View Details [567..643] MSA 3.457992 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.91

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle