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Protein Overview: Gprk2-PA, FBpp03...

General Information:
Name(s) found: FBpp0306622 [FlyBase]
Gprk2-PA / FBpp0085149 [FlyBase]
Description(s) found:
Found 26 descriptions.
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  • type=protein; loc=3R:join(27259559..27259610,27279033..27279128,27279188..27279308,27279373..27279978,27280117..27280222,27280297..27280486,27280929..27281177,27281250..27281407,27281466..27281675,27281770..27282033,27282096..27282188); ID=FBpp0306622; name=Gprk2-PB; parent=FBgn0261988,FBtr0334555; dbxref=FlyBase:FBpp0306622,FlyBase_Annotation_IDs:CG17998-PB,REFSEQ:NP_001263143,GB_protein:AGB96522; MD5=72b2ad0fd188cd0f8c887f9ad93039f3; length=714; release=r5.56; species=Dmel; [FlyBase]
  • The gene G protein-coupled receptor kinase 2 is referred to in FlyBase by the symbol Dmel\Gprk2 (CG17998, FBgn0004834). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:27230971..27283499. It has the cytological map location 100C3-100C4. There is experimental evidence that it has the molecular function</span>: G-protein coupled receptor kinase activity. There is experimental evidence that it is involved in the biological process</span>: smoothened signaling pathway. 13 alleles are reported. The phenotypes of these alleles are annotated with: antenna; egg; oocyte; egg operculum; egg chamber; segment; germarium; dorsal appendage; nurse cell. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 714 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDA]
    plasma membrane [IDA]
    Biological Process: G-protein coupled receptor protein signaling pathway [NAS]
    signal transduction [ISS]
    smoothened signaling pathway [IMP]
    regulation of G-protein coupled receptor protein signaling pathway [ISS]
    protein amino acid phosphorylation [IEA][ISS][NAS]
    Molecular Function: ATP binding [IEA]
    G-protein coupled receptor kinase activity [IMP][ISS][NAS]
    protein serine/threonine kinase activity [NAS]
    signal transducer activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELENIVANT VYLKAREGGS DSNKGKSKKW RKILQFPHIS QCINLKDKLD ISYGYVIDQQ  60
   61 PIGRELFRLF CENKRPVYFR YITFLDEVVK YEIEYISNRI FIGHDIGRRF LDVEAQLELR 120
  121 NGSGGDALDA ETQEELLLNS SNANPTETAE TEHCNNTTAN NCNNINNSNN SQHSSDINHK 180
  181 KLDTRNHNGD DATGNGSSHQ DDGDESVKCQ EGHDDAEKGG GGEGGGGGKC VPVGGYPDEL 240
  241 VLDVLNDDLI AQVRNKLNSG GKDIFAQCVN AVKAFLAGEP FREFESSMYF HRYLQWKWLE 300
  301 AQPITYKTFR MYRVLGKGGF GEVCACQVRA TGKMYACKKL EKKRIKKRKG ESMVLIEKQI 360
  361 LQKINSPFVV NLAYAYETKD ALCLVLTIMN GGDLKFHIYN MGGEPGFELE RARFYAAEVA 420
  421 CGLQHLHKQG IVYRDCKPEN ILLDDHGHVR ISDLGLAVEI PEGEMVRGRV GTVGYMAPEV 480
  481 IDNEKYAFSP DWFSFGCLLY EMIEGQAPFR MRKEKVKREE VDRRVKEDPE KYSSKFNDEA 540
  541 KSMCQQLLAK SIKQRLGCRN GRMGGQDVMA HPFFHSTQLN WRRLEAGMLE PPFVPDPHAV 600
  601 YAKDVLDIEQ FSTVKGVNID ESDTNFYTKF NTGSVSISWQ NEMMETECFR ELNVFGPEEC 660
  661 PTPDLQINAA PEPDKAGCFP FRRKKKQPAR TQPIPIPEHL LTTSHSVSST TVES

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..73] FFAS03 2.53 No description for 2acxA was found.
    2 View Details [74..142] PSI-BLAST 52.522879 No description for 2j0jA was found.
    3 View Details [143..714] PSI-BLAST 104.0 No description for 2acxA was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle