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Protein Overview: alph-PB

General Information:
Name(s) found: alph-PB / FBpp0084809 [FlyBase]
Description(s) found:
Found 18 descriptions.
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  • The gene alphabet is referred to in FlyBase by the symbol Dmel\alph (CG1906, FBgn0086361). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:25417544..25442879. It has the cytological map location 99B4-99B5. Based on sequence similarity, it is predicted to have molecular function</span>: protein serine/threonine phosphatase activity. There is experimental evidence that it is involved in the biological process</span>: positive regulation of R7 cell differentiation; mitotic cell cycle; negative regulation of Ras protein signal transduction; response to oxidative stress; negative regulation of MAP kinase activity; imaginal disc-derived wing morphogenesis; compound eye morphogenesis. 10 alleles are reported. The phenotypes of these alleles are annotated with: eye; primary pigment cell; cone cell; wing; wing vein. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 371 amino acids

    Gene Ontology:
    Cellular Component: protein serine/threonine phosphatase complex [IEA]
    Biological Process: response to oxidative stress [IMP]
    negative regulation of MAP kinase activity [IMP]
    negative regulation of Ras protein signal transduction [IMP]
    compound eye morphogenesis [IMP]
    protein amino acid dephosphorylation [IEA][NAS]
    imaginal disc-derived wing morphogenesis [IMP]
    positive regulation of R7 cell differentiation [IGI][IMP]
    mitotic cell cycle [IMP]
    Molecular Function: protein serine/threonine phosphatase activity [ISS][NAS]
    magnesium ion binding [IEA]
    manganese ion binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGGFLDKPKT AKHNDEGEGN KLLFGVSSMQ GWRSEMEDAY YARAGLGDAL PDWSFFAVFD  60
   61 GHAGCKVSEH CAKHLLESII STEEFIGGDH VKGIRTGFLR IDEVMRELPE FTRESEKCGG 120
  121 TTAVCAFVGL TQVYIANCGD SRAVLCRQGV PVFATQDHKP ILPEEKERIY NAGGSVMIKR 180
  181 VNGTLAVSRA LGDYDFKNVK EKGQCEQLVS PEPEIFCQSR QDSDEFLVLA CDGIWDVMSN 240
  241 EDVCSFIHSR MRVTSNLVSI ANQVVDTCLH KGSRDNMSII IIAFPGAPKP TEEAIEAEHR 300
  301 LEKQIEKITR DEIESSKITD YVDLLKCLQN RDDIEGLPPG GGLQSKYHVI ERTFKQEFPD 360
  361 RPCELYAYDD I

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..371] PSI-BLAST 91.0 CRYSTAL STRUCTURE OF THE PROTEIN SERINE/THREONINE PHOSPHATASE 2C AT 2 A RESOLUTION

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  7.29765002420868 bayes_pls_golite062009
  • phosphatase activity
    		•  6.46633224572308 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  6.25564034681743 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  6.20846750257603 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  5.62997267604309 bayes_pls_golite062009
  • hydrolase activity
    		•  2.93014592649821 bayes_pls_golite062009
  • binding
    		•  1.74689317666387 bayes_pls_golite062009
  • signal transducer activity
    		•  1.61688496161233 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.61688496161233 bayes_pls_golite062009
  • catalytic activity
    		•  1.53401212718168 bayes_pls_golite062009
  • protein binding
    		•  1.47578617076714 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle