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Protein Overview: CG11876-PB, CG11...

General Information:
Name(s) found: CG11876-PB / FBpp0084737 [FlyBase]
CG11876-PC / FBpp0084736 [FlyBase]
Description(s) found:
Found 32 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG11876 (CG11876, FBgn0039635). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:24938793..24941918. It has the cytological map location 98F10. Based on sequence similarity, it is predicted to have molecular function</span>: pyruvate dehydrogenase (acetyl-transferring) activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: pyruvate metabolic process. 3 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • This gene is referred to in FlyBase by the symbol Dmel\CG11876 (CG11876, FBgn0039635). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:24938793..24941918. It has the cytological map location 98F10. Based on sequence similarity, it is predicted to have molecular function</span>: pyruvate dehydrogenase (acetyl-transferring) activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: pyruvate metabolic process. 3 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 273 amino acids

    Gene Ontology:
    Cellular Component: lipid particle [IDA]
    pyruvate dehydrogenase complex [ISS]
    Biological Process: pyruvate metabolic process [ISS]
    Molecular Function: pyruvate dehydrogenase (acetyl-transferring) activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRTRLIQAA SSAQRAFSTS QKALAAKQMT VRDALNSALD DELARDDRVF ILGEEVAQYD  60
   61 GAYKVSRGLW KKYGDKRVID TPITEMGFAG IAVGAAMAGL RPVCEFMTWN FSMQAIDHAK 120
  121 ILDCAKPPVG DRPLPISLII ESPRSTWLNE INDILHRDRV GEVIAPPLDK SKSDKMEAAR 180
  181 LIVIRRRKMK KHKLKKLRRK MKFEWAKVRQ RREMRKEKAF QAKLISQIKQ AEAFSAEQHV 240
  241 AEILRQANET PLPRFWKGRR LPAFIIKQKL GIK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..273] PSI-BLAST 65.154902 E1-beta subunit of pyruvate dehydrogenase, Pyr module; E1-beta subunit of pyruvate dehydrogenase, C-domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • pyruvate dehydrogenase activity
    		•  9.86889243432924 bayes_pls_golite062009
  • pyruvate dehydrogenase (acetyl-transferring) activity
    		•  9.58140172137358 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
    		•  9.38144457641185 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  4.89064211833637 bayes_pls_golite062009
  • acetolactate synthase activity
    		•  1.59303412812463 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  0.723020204729919 bayes_pls_golite062009
  • catalytic activity
    		•  0.545407789079971 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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