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Protein Overview: Hrb98DE-PC, Hrb9...

General Information:
Name(s) found: Hrb98DE-PC / FBpp0084670 [FlyBase]
Hrb98DE-PB / FBpp0084669 [FlyBase]
Description(s) found:
Found 41 descriptions.
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  • The gene Heterogeneous nuclear ribonucleoprotein at 98DE is referred to in FlyBase by the symbol Dmel\Hrb98DE (CG9983, FBgn0001215). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:24425529..24431499. It has the cytological map location 98D6. There is experimental evidence that it has the molecular function</span>: sequence-specific DNA binding. There is experimental evidence that it is involved in the biological process</span>: negative regulation of RNA splicing; regulation of alternative nuclear mRNA splicing, via spliceosome. 12 alleles are reported. No phenotypic data is available. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
  • The gene Heterogeneous nuclear ribonucleoprotein at 98DE is referred to in FlyBase by the symbol Dmel\Hrb98DE (CG9983, FBgn0001215). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:24425529..24431499. It has the cytological map location 98D6. There is experimental evidence that it has the molecular function</span>: sequence-specific DNA binding. There is experimental evidence that it is involved in the biological process</span>: negative regulation of RNA splicing; regulation of alternative nuclear mRNA splicing, via spliceosome. 12 alleles are reported. No phenotypic data is available. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 365 amino acids

    Gene Ontology:
    Cellular Component: polytene chromosome puff [IDA]
    ribonucleoprotein complex [IDA][IPI][ISS][NAS]
    heterogeneous nuclear ribonucleoprotein complex [ISS]
    Biological Process: regulation of alternative nuclear mRNA splicing, via spliceosome [IMP]
    negative regulation of RNA splicing [IMP]
    Molecular Function: nucleotide binding [IEA]
    mRNA binding [ISS][NAS]
    sequence-specific DNA binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVNSNQNQNG NSNGHDDDFP QDSITEPEHM RKLFIGGLDY RTTDENLKAH FEKWGNIVDV  60
   61 VVMKDPRTKR SRGFGFITYS HSSMIDEAQK SRPHKIDGRV VEPKRAVPRQ DIDSPNAGAT 120
  121 VKKLFVGALK DDHDEQSIRD YFQHFGNIVD INIVIDKETG KKRGFAFVEF DDYDPVDKVV 180
  181 LQKQHQLNGK MVDVKKALPK QNDQQGGGGG RGGPGGRAGG NRGNMGGGNY GNQNGGGNWN 240
  241 NGGNNWGNNR GGNDNWGNNS FGGGGGGGGG YGGGNNSWGN NNPWDNGNGG GNFGGGGNNW 300
  301 NNGGNDFGGY QQNYGGGPQR GGGNFNNNRM QPYQGGGGFK AGGGNQGNYG GNNQGFNNGG 360
  361 NNRRY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..218] PSI-BLAST 54.69897 Crystal Structure of UP1 Complexed With d(TTAGGGTTAG(6-MI)G); A Human Telomeric Repeat Containing 6-methyl-8-(2-deoxy-beta-ribofuranosyl)isoxanthopteridine (6-MI)
    2 View Details [219..365] MSA 14.591997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  0.950788308762215 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.29562225149076 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle