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Protein Overview: CG4849-PA

General Information:
Name(s) found: CG4849-PA / FBpp0084626 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG4849 (CG4849, FBgn0039566). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:23789138..23792680. It has the cytological map location 98B6. Based on sequence similarity, it is predicted to have molecular function</span>: translation elongation factor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: nuclear mRNA splicing, via spliceosome; translational elongation. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 975 amino acids

    Gene Ontology:
    Cellular Component: catalytic step 2 spliceosome [IDA]
    precatalytic spliceosome [IDA]
    U5 snRNP [ISS]
    cytosol [ISS]
    small nuclear ribonucleoprotein complex [ISS]
    Biological Process: translational elongation [ISS]
    nuclear mRNA splicing, via spliceosome [IC][ISS]
    Molecular Function: GTP binding [IEA]
    translation elongation factor activity [ISS]
    GTPase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSDLYDEFG NYIGPDLDSD EEDEQSIYGQ PDVQDDPEDA MDEDEVEPQE DEDKEVTAVV  60
   61 LHEDKRYYPS AVEVYGPDVE TIVQEEDAQP LDKPLIEPVK KLKFQIKEQD MQETTYDMEF 120
  121 MADLMDTPPL IRNVALVGHL HHGKTTFVDC LIRQTHPQFE TMEERQLRYT DTLFTEQERG 180
  181 CSIKATPVTL VLQDVKQKSY LLNIFDTPGH VNFSDEATAA MRMSDGVVLF IDAAEGVMLN 240
  241 TERLLKHAVQ ERQAITVCIN KIDRLILELK LPPQDAYFKL KHIVEEVNGL LSTYGAPDDN 300
  301 LLVSPILGNV CFASSLYGFC FTLKSFAKLY ADTYEGVAYL DFAKRLWGDM YFNSKTRKFS 360
  361 KKQPHNSAQR SFVEFILEPM YKLIAQVVGD VDTTLSDTLA ELNVRVSKEE MKSNIRPLLR 420
  421 LVCNRFMGDC SGFVDMCVEH IKSPLENAKR KVDHIYTGPK EGDIYRDMIS CNQYGTLMVH 480
  481 SSKMYPNDDC TFFQVLARIV SGTLHAGQEV RVLGENYTLQ DEEDSRILQV GRLWVFESRY 540
  541 KVELNRVPAG NWVLIEGIDQ CIVKTSTIVD INVPEDLYIF RPLKFNTQSI IKIAVEPVNP 600
  601 SELPKMLDGL RKVNKSYPLL STRVEESGEH VILGTGELYL DCVMHDLRKM YSEIDIKVAD 660
  661 PVVAFCETVV ETSSLKCFAE TPNKKNKITM ISEPLEKGLA EDIENGTVCI NWNKKRIGEF 720
  721 FQVNYDWDLL AARSIWAFGP DSTGPNILVD DTLPSEVDKN LLTAVKDSIV QGFQWGTREG 780
  781 PLCEEPIRNV KFKILDGVIA NEALHRGGGQ IIPTARRVAY SAFLMATPRL MEPYLFVEVQ 840
  841 APADCVSAVY TVLARRRGHV TQDAPVSGSP IYTIKAFIPA IDSFGFETDL RTHTQGQAFC 900
  901 LSVFHHWQIV PGDPLDKSII IRPLEPQQAS HLAREFMIKT RRRKGLSEDV SINKFFDDPM 960
  961 LLELARQDVL INYPL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..126] PSI-BLAST 16.69897 No description for 2hjgA was found.
    2 View Details [127..975] PSI-BLAST 1000.0 Elongation factor 2 (eEF-2), domain II; Elongation factor 2 (eEF-2), N-terminal (G) domain; Elongation factor 2 (eEF-2), domain IV; Elongation factor 2 (eEF-2)


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle