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Protein Overview: l(3)mbt-PB

General Information:
Name(s) found: l(3)mbt-PB / FBpp0084545 [FlyBase]
Description(s) found:
Found 31 descriptions.
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  • The gene lethal (3) malignant brain tumor is referred to in FlyBase by the symbol Dmel\l(3)mbt (CG5954, FBgn0002441). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:23091952..23098995. It has the cytological map location 97F1. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: regulation of preblastoderm mitotic cell cycle; dendrite morphogenesis; negative regulation of gene expression; neuroblast proliferation; muscle organ development; negative regulation of transcription from RNA polymerase II promoter; syncytial nuclear migration. 15 alleles are reported. The phenotype of these alleles is annotated with: larval brain. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1477 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS]
    Myb complex [IDA]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [IMP]
    muscle organ development [IMP]
    negative regulation of gene expression [IMP]
    neuroblast proliferation [IMP]
    syncytial nuclear migration [IMP]
    regulation of transcription [IEA]
    regulation of preblastoderm mitotic cell cycle [IMP]
    dendrite morphogenesis [IMP]
    Molecular Function: transcription factor activity [ISS]
    protein binding [IPI]
    sequence-specific DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLPLSMASAE AKQLQRNISL SMSPANGGVI SPSTANCNGV ASASGGNPNP NSLLTLAPRK  60
   61 EELRFLPLAP MGGNKTCNIT ISNVQPMKSK LKSVNIVPNS IKSAGAGATV GSADAPLFQL 120
  121 VPSPSNPSQP LVAILAPNRK TTLLGGGASN GQPVVIRSGT PLHKNSLTVE TSNKPIQPGG 180
  181 SAAAAAVGGG TGGAPLTLVG KTVVPPKIQA ATPVQIPSTG PGAQVSLLAN PLKPRAPLIL 240
  241 SKVAVDKLRL KFSQVKSNPN ALVLGKANHV KKLLTSPNPS GEDKTRSTQK NNKQNTSASQ 300
  301 LKPVVAPKTA MPIATEVPTA DNNKMSLIKS KPVAIKAVPL PSQEAPIVPA VAPVVTSPEK 360
  361 VDVKPTAKPS IKTAPKPTPK PLEMSVNGPA KEKKAPAKEQ KQKTMDKPPV VKEIAQHTPC 420
  421 GPKELPKLKR SKSFVSNHPA SPVANNERRH SVAIMAKEVD VIEQPSAAIE TITIEDDDES 480
  481 EEEQQKPEIK KTPKQNQKPE KQEAPKKKQI PMPILPAGIT ISTTSTAKKK AVRKNSSVTT 540
  541 ISSSSSDSSS YSDVEVVPTK KTEKELSMLP GISIIKAESL PLSREDFERS LRCDEQVPQT 600
  601 PPKSSSSSSS GSHASEMSPP PKLADPKPSS PPAKNAKKAN DHDANPSPSS KTNDFKKSMM 660
  661 QNLNMLKWRG QQPANLQNST VRFELNEFNF LQINERCQPR QGPAAYFERP LYDRPGRRPS 720
  721 ACVHPLLYLC QRCNFHGPAA DFLAPHFCSV GCVRRSQKRR LPQSTQKESK ISRTQLEQTA 780
  781 GTAPDLPQKR QTNYKPHKSL SAIQEQLQQR QKDKPRKPFR WSEYLKSKGK DVAAPIHLFL 840
  841 NPFPISPNCF EIGMKLEAID PENCSLFCVC SIVEVRGYRL KLSFDGYSSM YDFWVNADSQ 900
  901 DIFPPGWCDE TARVLQAPKD YNSERFSWSR YLVKTGGKAA PRALFGHLNM QQQMDVRNGF 960
  961 AVGMHLEAED LNDTGKICVA TVTDILDERI RVHFDGWDDC YDLWVHITSP YIHPCGWHEG1020
 1021 RQQLIVPPDY QKSAFIWDDY ISEVGGMAAS KELFTPRQPM EYQERMKLEV VDQRNPCLIR1080
 1081 PATVVTRKGY RVQLHLDCWP TEYYFWLEDD SPDLHPIGWC EATSHELETP PGYLQPKSVM1140
 1141 PCDVEGCRGF GNAKRFNLNV HALRECCPYA PENWRQWRSK TVKPPRVAPE NIRRGWAKKT1200
 1201 KRACSEAKQA IKEDSQQEIV YPKVAEVVQA KRKTSPCEEK VVKKQKQMQK EEDAEQVPDE1260
 1261 RSLAIARSFV KDYGPQFLPN YRLWQLNSAF KLDDVRTNPL HWTSWDVCEY IERALDSTDI1320
 1321 AKVIFEQDID GRALLMLGRK ELDTYLKLKV GPAVKLYSLI LNLRIAVVCK FDSKNIELES1380
 1381 NTAGPIQREM DTPVSAIKQL PEQSQTNGYK TDHDQELSES GDDDDDEDVM LDSDDFLSVK1440
 1441 PSCLVIDEDA DGDGDCESDG DVAMVPMEVR TPLRTSS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..225] deduced N/A No confident structure predictions are available.
    2 View Details [226..434] MSA 2.213989 View MSA. No confident structure predictions are available.
    3 View Details [435..607] MSA 2.200988 View MSA. No confident structure predictions are available.
    4 View Details [608..739] MSA 1.172996 View MSA. No confident structure predictions are available.
    5 View Details [740..815] deduced N/A No confident structure predictions are available.
    6 View Details [816..1130] PSI-BLAST 144.0 No description for 2pqwA was found.
    7 View Details [1131..1299] FFAS03 1.59 No description for 2j63A was found.
    8 View Details [1300..1380] PSI-BLAST 20.522879 Scm SAM domain
    9 View Details [1381..1477] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8
    Term Confidence Notes
  • binding
    		•  3.32682088990761 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.30659353957398 bayes_pls_golite062009
  • DNA binding
    		•  2.70497733333132 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.6812146845966 bayes_pls_golite062009
  • transcription factor activity
    		•  2.23426547892206 bayes_pls_golite062009
  • protein binding
    		•  2.12913758162323 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.84254690430222 bayes_pls_golite062009
  • chromatin binding
    		•  1.6208950488941 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.31446495493975 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.51354463132415 bayes_pls_golite062009
  • catalytic activity
    		•  0.0451617952658021 bayes_pls_golite062009
    9 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.88

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle