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View Structure Prediction Details

Protein: l(3)mbt-PB
Organism: Drosophila melanogaster
Length: 1477 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for l(3)mbt-PB.

Description E-value Query
Range
Subject
Range
gi|7512049, gi|3... - pir||T13797 tumor supressor protein - fruit fly (Drosophila melanogaster), gi|3421009|emb|CAA56811.1...
898.0 [0..1] [1477..1]

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Predicted Domain #1
Region A:
Residues: [1-225]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLPLSMASAE AKQLQRNISL SMSPANGGVI SPSTANCNGV ASASGGNPNP NSLLTLAPRK  60
   61 EELRFLPLAP MGGNKTCNIT ISNVQPMKSK LKSVNIVPNS IKSAGAGATV GSADAPLFQL 120
  121 VPSPSNPSQP LVAILAPNRK TTLLGGGASN GQPVVIRSGT PLHKNSLTVE TSNKPIQPGG 180
  181 SAAAAAVGGG TGGAPLTLVG KTVVPPKIQA ATPVQIPSTG PGAQV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [226-434]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLLANPLKPR APLILSKVAV DKLRLKFSQV KSNPNALVLG KANHVKKLLT SPNPSGEDKT  60
   61 RSTQKNNKQN TSASQLKPVV APKTAMPIAT EVPTADNNKM SLIKSKPVAI KAVPLPSQEA 120
  121 PIVPAVAPVV TSPEKVDVKP TAKPSIKTAP KPTPKPLEMS VNGPAKEKKA PAKEQKQKTM 180
  181 DKPPVVKEIA QHTPCGPKEL PKLKRSKSF

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [435-607]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VSNHPASPVA NNERRHSVAI MAKEVDVIEQ PSAAIETITI EDDDESEEEQ QKPEIKKTPK  60
   61 QNQKPEKQEA PKKKQIPMPI LPAGITISTT STAKKKAVRK NSSVTTISSS SSDSSSYSDV 120
  121 EVVPTKKTEK ELSMLPGISI IKAESLPLSR EDFERSLRCD EQVPQTPPKS SSS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [608-739]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSSGSHASEM SPPPKLADPK PSSPPAKNAK KANDHDANPS PSSKTNDFKK SMMQNLNMLK  60
   61 WRGQQPANLQ NSTVRFELNE FNFLQINERC QPRQGPAAYF ERPLYDRPGR RPSACVHPLL 120
  121 YLCQRCNFHG PA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [740-815]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ADFLAPHFCS VGCVRRSQKR RLPQSTQKES KISRTQLEQT AGTAPDLPQK RQTNYKPHKS  60
   61 LSAIQEQLQQ RQKDKP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [816-1130]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKPFRWSEYL KSKGKDVAAP IHLFLNPFPI SPNCFEIGMK LEAIDPENCS LFCVCSIVEV  60
   61 RGYRLKLSFD GYSSMYDFWV NADSQDIFPP GWCDETARVL QAPKDYNSER FSWSRYLVKT 120
  121 GGKAAPRALF GHLNMQQQMD VRNGFAVGMH LEAEDLNDTG KICVATVTDI LDERIRVHFD 180
  181 GWDDCYDLWV HITSPYIHPC GWHEGRQQLI VPPDYQKSAF IWDDYISEVG GMAASKELFT 240
  241 PRQPMEYQER MKLEVVDQRN PCLIRPATVV TRKGYRVQLH LDCWPTEYYF WLEDDSPDLH 300
  301 PIGWCEATSH ELETP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 144.0
Match: 2pqwA
Description: No description for 2pqwA was found.

Predicted Domain #7
Region A:
Residues: [1131-1299]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PGYLQPKSVM PCDVEGCRGF GNAKRFNLNV HALRECCPYA PENWRQWRSK TVKPPRVAPE  60
   61 NIRRGWAKKT KRACSEAKQA IKEDSQQEIV YPKVAEVVQA KRKTSPCEEK VVKKQKQMQK 120
  121 EEDAEQVPDE RSLAIARSFV KDYGPQFLPN YRLWQLNSAF KLDDVRTNP

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.59
Match: 2j63A
Description: No description for 2j63A was found.

Predicted Domain #8
Region A:
Residues: [1300-1380]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LHWTSWDVCE YIERALDSTD IAKVIFEQDI DGRALLMLGR KELDTYLKLK VGPAVKLYSL  60
   61 ILNLRIAVVC KFDSKNIELE S

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.522879
Match: 1pk3A
Description: Scm SAM domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 3.32682088990761 bayes_pls_golite062009
transcription regulator activity 3.30659353957398 bayes_pls_golite062009
DNA binding 2.70497733333132 bayes_pls_golite062009
nucleic acid binding 2.6812146845966 bayes_pls_golite062009
transcription factor activity 2.23426547892206 bayes_pls_golite062009
protein binding 2.12913758162323 bayes_pls_golite062009
transcription repressor activity 1.84254690430222 bayes_pls_golite062009
chromatin binding 1.6208950488941 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.31446495493975 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.51354463132415 bayes_pls_golite062009
catalytic activity 0.0451617952658021 bayes_pls_golite062009

Predicted Domain #9
Region A:
Residues: [1381-1477]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NTAGPIQREM DTPVSAIKQL PEQSQTNGYK TDHDQELSES GDDDDDEDVM LDSDDFLSVK  60
   61 PSCLVIDEDA DGDGDCESDG DVAMVPMEVR TPLRTSS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
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