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Protein Overview: spz-PA

General Information:
Name(s) found: spz-PA / FBpp0084507 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene spatzle is referred to in FlyBase by the symbol Dmel\spz (CG6134, FBgn0003495). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:22890792..22895790. It has the cytological map location 97E1. There is experimental evidence that it has the molecular function</span>: growth factor activity; protein homodimerization activity; Toll binding. There is experimental evidence that it is involved in the biological process</span>: motor axon guidance; innate immune response; dorsal/ventral pattern formation; positive regulation of protein complex assembly; Toll signaling pathway; antifungal humoral response; dorsal/ventral axis specification; regulation of Toll signaling pathway; positive regulation of antifungal peptide biosynthetic process; oocyte dorsal/ventral axis specification. 61 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/first instar larval cuticle; embryonic/larval somatic muscle. It has 12 annotated transcripts and 12 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 326 amino acids

    Gene Ontology:
    Cellular Component: protein complex [IPI]
    extracellular region [IDA][NAS][TAS]
    Biological Process: Toll signaling pathway [IDA][NAS][TAS]
    motor axon guidance [IMP]
    regulation of Toll signaling pathway [IMP]
    maternal specification of dorsal/ventral axis, oocyte, germ-line encoded [TAS]
    dorsal/ventral axis specification [IGI][NAS][TAS]
    response to fungus [TAS]
    oocyte dorsal/ventral axis specification [IEP]
    embryonic axis specification [NAS]
    defense response [NAS][TAS]
    dorsal/ventral pattern formation [IDA]
    positive regulation of antifungal peptide biosynthetic process [IMP]
    immune response [TAS]
    innate immune response [IDA][NAS]
    antifungal humoral response [IMP]
    defense response to Gram-positive bacterium [TAS]
    positive regulation of protein complex assembly [IDA]
    Molecular Function: growth factor activity [IMP]
    protein homodimerization activity [IDA]
    Toll binding [IGI][IPI][NAS][TAS]
    cytokine activity [TAS]
    morphogen activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMTPMWISLF KVLLLLFAFF ATYEAKEYER IIKELFTITN DEGVVLFNTS ADSAPFMPIP  60
   61 TQHDDPTQKQ KQNQNQSPIP ETNRHYHQYH SLIQPDQYFK VQRSPNGKLN LVFNDTFVSL 120
  121 QRTDTEVQSE QPIPPRHPSD TFVFPDSPIA KYRPPQSPAR PLRNDTKEHN PCAKDESQHL 180
  181 RNFCTNVDDY PDLSGLTHKL KNNFAKFFSN DLQPTDVSSR VGGSDERFLC RSIRKLVYPK 240
  241 KGLRADDTWQ LIVNNDEYKQ AIQIEECEGA DQPCDFAANF PQSYNPICKQ HYTQQTLASI 300
  301 KSDGELDVVQ NSFKIPSCCK CALKTG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..207] MSA 1.023941 View MSA. No confident structure predictions are available.
    2 View Details [208..326] PSI-BLAST 19.0 Coagulogen


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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