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Protein Overview: BM-40-SPARC-PA, ...

General Information:
Name(s) found: FBpp0306424 [FlyBase]
BM-40-SPARC-PA / FBpp0084464 [FlyBase]
Description(s) found:
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  • gi|4499900|emb|CAB39319.1| BM-40 [Drosophila melanogaster] [NCBI NR]
  • gi|24650420|ref|NP_651509.2| BM-40-SPARC [Drosophila melanogaster] [NCBI NR]
  • gi|10726793|gb|AAF56632.2| BM-40-SPARC [Drosophila melanogaster] [NCBI NR]
  • type=protein; loc=3R:complement(22695100..22695852,22695915..22696076); ID=FBpp0306424; name=BM-40-SPARC-PB; parent=FBgn0026562,FBtr0334309; dbxref=FlyBase:FBpp0306424,FlyBase_Annotation_IDs:CG6378-PB,REFSEQ:NP_001262998,GB_protein:AGB96378; MD5=d20d0440fe5a65d9b797f14e06a9bde8; length=304; release=r5.56; species=Dmel; [FlyBase]
  • The gene BM-40-SPARC is referred to in FlyBase by the symbol Dmel\BM-40-SPARC (CG6378, FBgn0026562). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:22694954..22697738. It has the cytological map location 97D3. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: calcium ion binding. There is experimental evidence that it is involved in the biological process</span>: mesoderm development. 19 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG6378-PA translation from_gene[CG6378 BM-40-SPARC FBgn0026562] seq_release:3 mol_weight=35183 cds_boundaries:(3R:22,684,468..22,685,441[-]) aa_length:304 transcript_info:[CG6378-RA seq_release:3] gene_info:[gene symbol:BM-40-SPARC FBgn0026562 gene_bo [hmr_yeast5_DM3-1_pombe.fasta]
  • (O97365) BM-40 precursor (BM-40/SPARC protein) [DrosMelano7227.FASTAC.txt]
  • (AE003758) BM-40/SPARC gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG6378-PA [Drosophila melanogaster]gi|24650420|ref|NP_651509.2| CG6378-PA [Drosophila melanogaster]gi|4499900|emb|CAB39319.1| BM-40 [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:complement(22695100..22695852,22695915..22696076); ID=FBpp0084464; name=BM-40-SPARC-PA; parent=FBgn0026562,FBtr0085094; dbxref=FlyBase:FBpp0084464,FlyBase_Annotation_IDs:CG6378-PA,GB_protein:AAF56632.2,REFSEQ:NP_651509,GB_protein:AAF5 [fly-100309-contam.fasta]
  • CG6378-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • BM-40-SPARC CG6378-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • BM-40 [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3R:complement(22695100..22695852,22695915..22696076); ID=FBpp0084464; name=BM-40-SPARC-PA; parent=FBgn0026562,FBtr0085094; dbxref=FlyBase:FBpp0084464,FlyBase_Annotation_IDs:CG6378-PA,GB_protein:AAF56632.2,REFSEQ:NP_651509,GB_protein:AAF56632; MD5=d20d0440fe5a65d9b797f14e06a9bde8; length=304; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:complement(22695100..22695852,22695915..22696076); ID=FBpp0084464; name=BM-40-SPARC-PA; parent=FBgn0026562,FBtr0085094; dbxref=FlyBase:FBpp0084464,FlyBase_Annotation_IDs:CG6378-PA,GB_protein:AAF56632.2,REFSEQ:NP_651509,GB_protein:AAF56632; MD5=d20d0440fe5a65d9b797f14e06a9bde8; length=304; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • BM-40 OS=Drosophila melanogaster GN=BM-40-SPARC PE=1 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=3R:complement(22695100..22695852,22695915..22696076); ID=FBpp0084464; name=BM-40-SPARC-PA; parent=FBgn0026562,FBtr0085094; dbxref=FlyBase:FBpp0084464,FlyBase_Annotation_IDs:CG6378-PA,GB_protein:AAF56632.2,REFSEQ:NP_651509,GB_protein:AAF56632,FlyMine:FBpp0084464,modMine:FBpp0084464; MD5=d20d0440fe5a65d9b797f14e06a9bde8; length=304; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • BM-40 OS=Drosophila melanogaster GN=BM-40-SPARC PE=2 SV=1 [UniProt_D_Melanogaster_07132012_07-13-2012_reversed.fasta]
  • type=protein; loc=3R:complement(join(26870193..26870354,26869378..26870130)); ID=FBpp0084464; name=BM-40-SPARC-PA; parent=FBgn0026562,FBtr0085094; dbxref=FlyBase:FBpp0084464,FlyBase_Annotation_IDs:CG6378-PA,GB_protein:AAF56632.2,REFSEQ:NP_651509,GB_protein:AAF56632,FlyMine:FBpp0084464,modMine:FBpp0084464; MD5=d20d0440fe5a65d9b797f14e06a9bde8; length=304; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:complement(join(26870193..26870354,26869378..26870130)); ID=FBpp0306424; name=BM-40-SPARC-PB; parent=FBgn0026562,FBtr0334309; dbxref=FlyBase:FBpp0306424,FlyBase_Annotation_IDs:CG6378-PB,REFSEQ:NP_001262998,GB_protein:AGB96378; MD5=d20d0440fe5a65d9b797f14e06a9bde8; length=304; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:complement(join(26870193..26870354,26869378..26870130)); ID=FBpp0084464; name=SPARC-PA; parent=FBgn0026562,FBtr0085094; dbxref=FlyBase:FBpp0084464,FlyBase_Annotation_IDs:CG6378-PA,GB_protein:AAF56632.2,REFSEQ:NP_651509,GB_protein:AAF56632,FlyMine:FBpp0084464,modMine:FBpp0084464; MD5=d20d0440fe5a65d9b797f14e06a9bde8; length=304; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • type=protein; loc=3R:complement(join(26870193..26870354,26869378..26870130)); ID=FBpp0306424; name=SPARC-PB; parent=FBgn0026562,FBtr0334309; dbxref=FlyBase:FBpp0306424,FlyBase_Annotation_IDs:CG6378-PB,REFSEQ:NP_001262998,GB_protein:AGB96378; MD5=d20d0440fe5a65d9b797f14e06a9bde8; length=304; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • BM-40 OS=Drosophila melanogaster GN=SPARC PE=1 SV=1 [DROME.fasta.20160308]
  • FBpp0084464 type=protein; loc=3R:complement(join(26870193..26870354,26869378..26870130)); ID=FBpp0084464; name=SPARC-PA; parent=FBgn0026562,FBtr0085094; dbxref=FlyBase:FBpp0084464,FlyBase_Annotation_IDs:CG6378-PA,GB_protein:AAF56632.2,REFSEQ:NP_651509,GB_protein:AAF56632,FlyMine:FBpp0084464,modMine:FBpp0084464; MD5=d20d0440fe5a65d9b797f14e06a9bde8; length=304; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • FBpp0306424 type=protein; loc=3R:complement(join(26870193..26870354,26869378..26870130)); ID=FBpp0306424; name=SPARC-PB; parent=FBgn0026562,FBtr0334309; dbxref=FlyBase:FBpp0306424,FlyBase_Annotation_IDs:CG6378-PB,REFSEQ:NP_001262998,GB_protein:AGB96378; MD5=d20d0440fe5a65d9b797f14e06a9bde8; length=304; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:complement(join(26870193..26870354,26869378..26870130)); ID=FBpp0084464; name=SPARC-PA; parent=FBgn0026562,FBtr0085094; dbxref=FlyBase:FBpp0084464,FlyBase_Annotation_IDs:CG6378-PA,GB_protein:AAF56632.2,REFSEQ:NP_651509,GB_protein:AAF56632,UniProt/TrEMBL:O97365,FlyMine:FBpp0084464,modMine:FBpp0084464; MD5=d20d0440fe5a65d9b797f14e06a9bde8; length=304; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
  • type=protein; loc=3R:complement(join(26870193..26870354,26869378..26870130)); ID=FBpp0306424; name=SPARC-PB; parent=FBgn0026562,FBtr0334309; dbxref=FlyBase:FBpp0306424,FlyBase_Annotation_IDs:CG6378-PB,REFSEQ:NP_001262998,GB_protein:AGB96378,UniProt/TrEMBL:O97365; MD5=d20d0440fe5a65d9b797f14e06a9bde8; length=304; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 304 amino acids

    Gene Ontology:
    Cellular Component: basement membrane [NAS]
    proteinaceous extracellular matrix [ISS]
    Biological Process: mesoderm development [IEP]
    cell adhesion [ISS]
    Molecular Function: calcium ion binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRSLWLLLGL GLLAVSHVQA STEFSEDLLD EDLDLSDIDE NEEEFLRLLE EKNKIKDIER  60
   61 ENEIATKLAE VQHNLLNPVV EVDLCETMSC GAGRICQMHD EKPKCVCIPE CPEEVDTRRL 120
  121 VCTNTNETWP SDCSVYQQRC WCDSGEPGCT NPDNAHMHID YYGACHEPRS CEGEDLKDFP 180
  181 RRMRDWLFNV MRDLAERDEL TEHYMQMELE AETNNSRRWS NAAVWKWCDL DGDTDRSVSR 240
  241 HELFPIRAPL VSLEHCIAPF LESCDSNKDH RITLVEWGAC LELDPEDLKE RCDDVQRAQP 300
  301 HLLG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..76] PSI-BLAST 5.154902 NMR structure of the human NOTCH-1 ligand binding region
    2 View Details [77..304] PSI-BLAST 21.69897 C-terminal (EC) domain of BM-40/SPARC/osteonectin; Domain of BM-40/SPARC/osteonectin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • receptor binding
    		•  3.70076684537777 bayes_pls_golite062009
  • growth factor activity
    		•  2.98754787930869 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.95292425479529 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  1.69932456942774 bayes_pls_golite062009
  • heparin binding
    		•  1.31822233987881 bayes_pls_golite062009
  • carbohydrate binding
    		•  1.17408158237797 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  0.99490013107685 bayes_pls_golite062009
  • extracellular matrix structural constituent
    		•  0.6530199085873 bayes_pls_golite062009
  • pattern binding
    		•  0.59201056851242 bayes_pls_golite062009
  • binding
    		•  0.579955062442584 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  0.419873715675914 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  0.36654473042467 bayes_pls_golite062009
  • protein binding
    		•  0.351109672530073 bayes_pls_golite062009
  • endopeptidase inhibitor activity
    		•  0.135824207842184 bayes_pls_golite062009
  • enzyme inhibitor activity
    		•  0.0195598784999702 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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