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View Structure Prediction Details

Protein: BM-40-SPARC-PA, ...
Organism: Drosophila melanogaster
Length: 304 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BM-40-SPARC-PA, ....

Description E-value Query
Range
Subject
Range
gi|50755132 - gi|50755132|ref|XP_414622.1| PREDICTED: similar to Testican-1 precursor (SPOCK protein) [Gallus gall...
145.0 [0..29] [302..396]

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Predicted Domain #1
Region A:
Residues: [1-76]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRSLWLLLGL GLLAVSHVQA STEFSEDLLD EDLDLSDIDE NEEEFLRLLE EKNKIKDIER  60
   61 ENEIATKLAE VQHNLL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.154902
Match: 1tozA
Description: NMR structure of the human NOTCH-1 ligand binding region
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [77-304]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPVVEVDLCE TMSCGAGRIC QMHDEKPKCV CIPECPEEVD TRRLVCTNTN ETWPSDCSVY  60
   61 QQRCWCDSGE PGCTNPDNAH MHIDYYGACH EPRSCEGEDL KDFPRRMRDW LFNVMRDLAE 120
  121 RDELTEHYMQ MELEAETNNS RRWSNAAVWK WCDLDGDTDR SVSRHELFPI RAPLVSLEHC 180
  181 IAPFLESCDS NKDHRITLVE WGACLELDPE DLKERCDDVQ RAQPHLLG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.69897
Match: 1nubA
Description: C-terminal (EC) domain of BM-40/SPARC/osteonectin; Domain of BM-40/SPARC/osteonectin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor binding 3.70076684537777 bayes_pls_golite062009
growth factor activity 2.98754787930869 bayes_pls_golite062009
polysaccharide binding 1.95292425479529 bayes_pls_golite062009
glycosaminoglycan binding 1.69932456942774 bayes_pls_golite062009
heparin binding 1.31822233987881 bayes_pls_golite062009
carbohydrate binding 1.17408158237797 bayes_pls_golite062009
epidermal growth factor receptor binding 0.99490013107685 bayes_pls_golite062009
extracellular matrix structural constituent 0.6530199085873 bayes_pls_golite062009
pattern binding 0.59201056851242 bayes_pls_golite062009
binding 0.579955062442584 bayes_pls_golite062009
ErbB-2 class receptor binding 0.419873715675914 bayes_pls_golite062009
ErbB-3 class receptor binding 0.36654473042467 bayes_pls_golite062009
protein binding 0.351109672530073 bayes_pls_golite062009
endopeptidase inhibitor activity 0.135824207842184 bayes_pls_golite062009
enzyme inhibitor activity 0.0195598784999702 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle