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Protein Overview: Smg6-PA

General Information:
Name(s) found: Smg6-PA / FBpp0084171 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene Smg6 is referred to in FlyBase by the symbol Dmel\Smg6 (CG6369, FBgn0039260). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:20855145..20859177. It has the cytological map location 96B17. There is experimental evidence that it has the molecular function</span>: ribonuclease activity. There is experimental evidence that it is involved in the biological process</span>: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. 16 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 948 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [IMP]
    [NOT]gene silencing by miRNA [IMP]
    [NOT]RNA interference [IMP]
    Molecular Function: ribonuclease activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRKGTREQN DISLIIGTLP KRLQNKIAAS CSHAAAAATT TKALETENAE NAEPVATTAN  60
   61 ASRPVEILSN ASTGGGKPDA QSKQPVLDTS GKMAWEGGIP GILRVTTSVA GDVNRNGQGQ 120
  121 GKNKSGNSAR RRGRKDKEHA TQSPVTRTRL TTEHPDWFEP LLGLPHAKNI VHLYDQLMVL 180
  181 NQRNLILINW KNFCYIHDQL QDAFKQLLLE QLKFVCEHKV DVFFWKLLFY NVRNYLKRQQ 240
  241 TDQAHTHTLL LIEQAIKFYR MLYDKLMAKC VASSRCDSAL KVVAQRLLIC LGDLTRYRVN 300
  301 HVKATDYMEA ARYYQRAQEL VPGNGAPFNQ LAVISIYHHK RFDAVYYYVR SLLTSNSIQS 360
  361 AKESLLDLFD EIRRKYEETE MKQSPMHYAA GSKNQKSKQM RKEVWIYPDG IRRLHRTDDK 420
  421 GNKAKGNKAT MAEVNRYEEM PPEEILPRIV SLYLYLLGKL YTGTDVDSLY PLLRKLQIQI 480
  481 GVALRHENLL SRSKLLKIVA LNLFVVEHNK PKTSRREMRY HSFNFANSFF GLMMKKTNQL 540
  541 LAGFVEDSTN VQCLPEEDFA TVNTYLQFVN VYVRWLSISL DVWEPVRSEE HSFIDCWAEL 600
  601 TILFEYIECL MGKHKLEKNE ILLDEDVALR GFTPLGRETL SMDYLKRGSE RLQFFERVRR 660
  661 IGQFQEYYVQ HQEALQQPLE SSFTVEHLNA AMKNALENYD AESCGLAANV SKIQCKAVEE 720
  721 LLCRSTDSDV SELCKLKKEL EAKARVKQIC TSKLEDILKF VDTKIYIEVR PRYLLPDTNC 780
  781 FIDCLEDFEK LSTEFKRYTL IIPLTVVKEL DGLSKGVKLD SYRSSKQTQR IHHFDEVSSR 840
  841 AKKSLEFIKS AKGNVKCATT KGSFVNASVF ALVEEEYLSN DDKILATAMA VSKTAKTEQC 900
  901 TDGKCFIQTE LVLITTDRNL RVKALSRNLA VSALDEFLQW AKDCREST

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..168] deduced N/A No confident structure predictions are available.
    2 View Details [169..684] PSI-BLAST 28.045757 Crystal structure of the N-terminal domain of human SMG7
    3 View Details [685..777] deduced N/A No confident structure predictions are available.
    4 View Details [778..948] PSI-BLAST 35.154902 No description for 2dokA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  0.787280988128024 bayes_pls_golite062009
  • protein binding
    		•  0.212989569759479 bayes_pls_golite062009
  • hydrolase activity
    		•  0.142615944899055 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.89

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle