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Protein Overview: Tsc1-PA

General Information:
Name(s) found: Tsc1-PA / FBpp0083931 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene Tsc1 is referred to in FlyBase by the symbol Dmel\Tsc1 (CG6147, FBgn0026317). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:19956032..19960376. It has the cytological map location 95E1. There is experimental evidence that it has the molecular function</span>: kinase binding. There is experimental evidence for 11 unique biological process</span> terms, many of which group under: regulation of biological process; regulation of anatomical structure size; negative regulation of growth; negative regulation of cell size; regulation of developmental process; response to nutrient levels; regulation of response to stimulus; determination of adult lifespan; primary metabolic process; regulation of cell cycle; lipid metabolic process; cell communication; regulation of cellular component size; negative regulation of cell proliferation; negative regulation of organ growth; response to chemical stimulus; aging. 24 alleles are reported. The phenotype of these alleles is annotated with: fat body. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1100 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDA]
    Biological Process: insulin receptor signaling pathway [NAS]
    signal transduction [IGI]
    negative regulation of cell proliferation [IGI][IMP]
    determination of adult lifespan [IMP]
    regulation of organ growth [NAS]
    response to nutrient [IMP]
    negative regulation of organ growth [IGI][IMP]
    negative regulation of insulin receptor signaling pathway [IGI]
    regulation of timing of cell differentiation [IMP]
    negative regulation of cell growth [IGI][IMP][TAS]
    regulation of cell growth [TAS]
    negative regulation of cell size [IGI][IMP][NAS][TAS]
    lipid metabolic process [IGI]
    regulation of cell cycle [IMP][TAS]
    Molecular Function: kinase binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVIEKIIGDL ESNMTLENEE AKRKLVELLS QNKEQWVVKF MLDYFFTTGS QRILEVLVKA  60
   61 QAPHDGYIFD KLDDCLKQSQ HRVQSLQVFC FIVRHHPTWL YKIEKHRLIK SVFKLMTHEK 120
  121 EIVPLMSALL CIITLLPIIP NSVPNFLNDL FEVFGHLASW KLQNSNKLPD EKLVHLQLGL 180
  181 QMLFHRLYGM YPCSFIAYLV EFIKRGNGGG IFQHTIKPLL NTVRVHPMLV TATPETEVNN 240
  241 TRWKEMEPHD VVMECANLSL PVLLPETSNE DGSYAYPMTP GYSRMTSNTS NTDYSYQLRE 300
  301 FQQSRNVYTR FDSFASGDDV GPIWSPHNEI ATTSSGIPLT PTTSFILPLQ PAMNSQLMVG 360
  361 MTGSSPPEAA VEATPETTPL KDMRDIKQPG RAVNSHAVRA IFAVSQPSSP MRKDQQSQFS 420
  421 FPDVSREAEE SSHSYLEVNR GTAYDRRLSQ VIQDRHNVER SVNTPCPSSL PEINSDLSLV 480
  481 GGSVYPSVTQ EVAAVCGECN ETDRNLCSVG GLHMPTSRSM HQLAKKRRNR MASYSGNGSC 540
  541 ADSRSSAAKK ASWSTEAENP MRRTKSCSAL SGMRQQHLEE NDDEADCSSQ RQRGENGNTQ 600
  601 KTGSRLQRSG RNLAISAPKD TARSCTHAST QTVEGLDSAP AQYENWLIEL LLECKEQRID 660
  661 YERNLLYPQD ILDEYIKHAI KANESFDAEQ GQLMCLQLEY ESYRRSIHAE RNRRLMGRSR 720
  721 DKRSLEMERD RLREQLKNFD AKNKDLANKM DQAIRLANER QNIHQEELGE MRAKYQHELE 780
  781 EKKCLRQAND DLQTRLTSEL ARHKEMNYEL ESLRGQVFSL GTELQHTQQQ ADIGLQCKQE 840
  841 LARLEAEFII MGEVQVRCRD RLAEIDNFRA RDEELQMLQE SSNLELKDLR HSLDEKTSQL 900
  901 ESMKHKISDL QAQLANSEKA MTEQKRLLST VKDEYEEKFK SVNKKYDVQK KIIMQMEEKL 960
  961 MMMMQQPQGT TGHNTCSPDT DRTDIASSIE RNSPLSTSLA SSESLSASLR STELKNLHQL1020
 1021 VDTPTIPDVL NSMAGGAQFE DEVRPPAVDL ASSASTASAI NIVPHALDLP STSGGIGHTL1080
 1081 THPHPHPHLH LQQQQQDQLQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..249] deduced N/A No confident structure predictions are available.
    2 View Details [250..352] deduced N/A No confident structure predictions are available.
    3 View Details [353..707] PSI-BLAST 19.522879 Heavy meromyosin subfragment
    4 View Details [708..1100] PSI-BLAST 7.69897 No description for 2dfsA was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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