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Protein Overview: Pli-PB, Pli-PA

General Information:
Name(s) found: Pli-PB / FBpp0111820 [FlyBase]
Pli-PA / FBpp0083913 [FlyBase]
Description(s) found:
Found 43 descriptions.
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  • The gene Pellino is referred to in FlyBase by the symbol Dmel\Pli (CG5212, FBgn0025574). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:19685884..19715797. It has the cytological map location 95C5-95C8. There is experimental evidence that it has the molecular function</span>: kinase regulator activity. There is experimental evidence that it is involved in the biological process</span>: Toll signaling pathway. 12 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • The gene Pellino is referred to in FlyBase by the symbol Dmel\Pli (CG5212, FBgn0025574). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:19685884..19715797. It has the cytological map location 95C5-95C8. There is experimental evidence that it has the molecular function</span>: kinase regulator activity. There is experimental evidence that it is involved in the biological process</span>: Toll signaling pathway. 12 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 424 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: Toll signaling pathway [IMP][TAS]
    immune response [TAS]
    signal transduction [NAS]
    defense response [NAS]
    Molecular Function: kinase regulator activity [IMP]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVKRTDGTES PILAEDGGDG HDKPRLRYGE LVILGYNGYL PQGDRGRRRS KFVLHKRTEA  60
   61 SGVKRSKHYI VQSPQTSKAI LDANQHSISY TLSRNQAVIV EYKEDTETDM FQVGRSSESP 120
  121 IDFVVMDTLP GDKKDAKVMQ STISRFACRI LVNRCEPAKA RIFAAGFDSS RNIFLGEKAT 180
  181 KWQDNVEIDG LTTNGVLIMH PKGSFCGGNA KCGLWRECSV GGDVFSLRES RSAQQKGQPI 240
  241 YDECNILQDG TLIDLCGATL LWRSAEGLQH SPTKHDLEKL IDAINAGRPQ CPVGLNTLVI 300
  301 PRKVNIGDQV NQPYVYLNCG HVQGHHDWGQ DENTGARRCP MCLELGPVVT LCMGLEPAFY 360
  361 VDVGAPTYAF NPCGHMATEK TVKYWANVEI PHGTNGFQAV CPFCATPLDG ATGYIKLIFQ 420
  421 DNLD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..183] MSA 2.015921 View MSA. No confident structure predictions are available.
    2 View Details [184..236] MSA 2.016982 View MSA. No confident structure predictions are available.
    3 View Details [237..333] deduced N/A No confident structure predictions are available.
    4 View Details [334..424] FFAS03 1.18 Not-4 N-terminal RING finger domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • binding
    		•  2.06923986676721 bayes_pls_golite062009
  • protein binding
    		•  1.48593945455888 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.324292450240439 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.248014157054608 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle