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Protein Overview: SPE-PA

General Information:
Name(s) found: SPE-PA / FBpp0083832 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene Spatzle-Processing Enzyme is referred to in FlyBase by the symbol Dmel\SPE (CG16705, FBgn0039102). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:19511992..19513873. It has the cytological map location 95A7. Based on sequence similarity, it is predicted to have molecular function</span>: serine-type endopeptidase activity. There is experimental evidence that it is involved in the biological process</span>: defense response to fungus; zymogen activation; innate immune response; positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria; Toll signaling pathway; defense response to Gram-positive bacterium; defense response to Gram-negative bacterium; positive regulation of Toll signaling pathway. 9 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 400 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: Toll signaling pathway [IDA]
    zymogen activation [IDA]
    defense response to Gram-negative bacterium [IMP]
    innate immune response [IMP]
    proteolysis [IEA][NAS]
    positive regulation of Toll signaling pathway [IMP]
    defense response to fungus [IMP]
    positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria [IDA]
    defense response to Gram-positive bacterium [IMP]
    Molecular Function: serine-type endopeptidase activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASTERNFLL LSLVVSALSG LVHRSDAAEI SFGSCTPQQS DERGQCVHIT SCPYLANLLM  60
   61 VEPKTPAQRI LLSKSQCGLD NRVEGLVNRI LVCCPQSMRG NIMDSEPTPS TRDALQQGDV 120
  121 LPGNDVCGFL FADRIFGGTN TTLWEFPWMV LLQYKKLFSE TYTFNCGGAL LNSRYVLTAG 180
  181 HCLASRELDK SGAVLHSVRL GEWDTRTDPD CTTQMNGQRI CAPKHIDIEV EKGIIHEMYA 240
  241 PNSVDQRNDI ALVRLKRIVS YTDYVRPICL PTDGLVQNNF VDYGMDVAGW GLTENMQPSA 300
  301 IKLKITVNVW NLTSCQEKYS SFKVKLDDSQ MCAGGQLGVD TCGGDSGGPL MVPISTGGRD 360
  361 VFYIAGVTSY GTKPCGLKGW PGVYTRTGAF IDWIKQKLEP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..126] PSI-BLAST 11.0 Factor X, N-terminal module
    2 View Details [127..400] PSI-BLAST 58.522879 No description for 2olgA was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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