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Protein Overview: Irp-1A-PA

General Information:
Name(s) found: Irp-1A-PA / FBpp0083720 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene Iron regulatory protein 1A is referred to in FlyBase by the symbol Dmel\Irp-1A (CG4900, FBgn0024958). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:18547042..18550325. It has the cytological map location 94C3. There is experimental evidence that it has the molecular function</span>: iron-responsive element binding; aconitate hydratase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: regulation of translational initiation by iron. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 902 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: regulation of translational initiation by iron [ISS][NAS]
    Molecular Function: iron ion binding [ISS][NAS]
    iron-responsive element binding [IDA]
    mRNA binding [ISS][NAS]
    4 iron, 4 sulfur cluster binding [IEA]
    aconitate hydratase activity [IDA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGSGANPFA QFQESFTQDG NVYKYFDLPS IDSKYESLPF SIRVLLESAV RNCDNFHVLE  60
   61 KDVQSILGWT PSLKQETSDV EVSFKPARVI LQDFTGVPAV VDFAAMRDAV RELGGNPEKI 120
  121 NPICPADLVI DHSVQVDFVR SSDALTKNES LEFQRNKERF TFLKWGARAF DNMLIVPPGS 180
  181 GIVHQVNLEY LARVVFESDS SADGSKILYP DSVVGTDSHT TMINGLGVLG WGVGGIEAEA 240
  241 VMLGQSISML LPEVIGYRLE GKLGPLATST DLVLTITKHL RQLGVVGKFV EFYGPGVAEL 300
  301 SIADRATISN MCPEYGATVG YFPIDENTLS YMRQTNRSEK KIDIIRKYLK ATRQLRDYSL 360
  361 VDQDPQYTES VTLDLSTVVT SVSGPKRPHD RVSVSSMCED FKSCLISPVG FKGFAIPPSA 420
  421 LAASGEFQWD DGKSYKIGHG SVVIAAITSC TNTSNPSVML GAGLLAKNAV QKGLSILPYI 480
  481 KTSLSPGSGV VTYYLRESGV IPYLEQLGFD IVGYGCMTCI GNSGPLDENV VNTIEKNGLV 540
  541 CCGVLSGNRN FEGRIHPNTR ANYLASPLLV IAYAIAGRVD IDFEIEPLGV DSNGKEVFLR 600
  601 DIWPTRSEIQ EVEHKHVIPA MFQEVYSKIQ LGSRDWQTLE VSDSKLYPWS EISTYIKLPP 660
  661 FFEGMTRALP KLKGIEKARC LLLLGDSVTT DHISPAGSIA RKSPAARYLS ERGLTPRDFN 720
  721 SYGSRRGNDA VMARGTFANI RLVNKLASKT GPSTLHVPSG EEMDIFDAAE RYASEGTPLV 780
  781 LVVGKDYGSG SSRDWAAKGP FLLGIKAVIA ESYERIHRSN LVGMGIIPLQ FLPGQSADTL 840
  841 KLSGREVYNI VLPEGELKPG QRIQVDADGN VFETTLRFDT EVDITYYKNG GILNYMIRKM 900
  901 LD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..902] PSI-BLAST 1000.0 Structure of an orthorhombic crystal form of human cytosolic aconitase (IRP1)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • aconitate hydratase activity
    		•  5.86356477922338 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  5.49717480487827 bayes_pls_golite062009
  • structural molecule activity
    		•  5.20352686802457 bayes_pls_golite062009
  • catalytic activity
    		•  2.4040324437254 bayes_pls_golite062009
  • mRNA binding
    		•  2.2758554402042 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.25736437672211 bayes_pls_golite062009
  • carbon-oxygen lyase activity
    		•  2.08349115784849 bayes_pls_golite062009
  • hydro-lyase activity
    		•  2.04845291489052 bayes_pls_golite062009
  • 3-isopropylmalate dehydratase activity
    		•  2.02813271581491 bayes_pls_golite062009
  • lyase activity
    		•  2.0080619912194 bayes_pls_golite062009
  • RNA binding
    		•  2.00311670878109 bayes_pls_golite062009
  • metal cluster binding
    		•  1.70706327499066 bayes_pls_golite062009
  • iron-sulfur cluster binding
    		•  1.70706327499066 bayes_pls_golite062009
  • binding
    		•  1.67914740974449 bayes_pls_golite062009
  • DNA binding
    		•  1.6436451615422 bayes_pls_golite062009
  • iron-responsive element binding
    		•  1.1980380564483 bayes_pls_golite062009
  • iron ion binding
    		•  1.12961684198784 bayes_pls_golite062009
  • 4 iron, 4 sulfur cluster binding
    		•  1.11810757572823 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.342428816025605 bayes_pls_golite062009
  • protein binding
    		•  0.232638130896339 bayes_pls_golite062009
  • cation binding
    		•  0.0272064751959212 bayes_pls_golite062009
  • metal ion binding
    		•  0.0272064751959212 bayes_pls_golite062009
  • ion binding
    		•  0.0228992031160024 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle