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Protein Overview: GABA-B-R2-PB

General Information:
Name(s) found: GABA-B-R2-PB / FBpp0083566 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene metabotropic GABA-B receptor subtype 2 is referred to in FlyBase by the symbol Dmel\GABA-B-R2 (CG6706, FBgn0027575). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:17596055..17601562. It has the cytological map location 93F9. Based on sequence similarity, it is predicted to have molecular function</span>: GABA-B receptor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: G-protein coupled receptor protein signaling pathway. One allele is reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1221 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [IEA][ISS]
    Biological Process: G-protein coupled receptor protein signaling pathway [IEA][ISS]
    Molecular Function: G-protein coupled receptor activity [IEA]
    GABA-B receptor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFRPSWFPFA SLLFLLLWST ACGRTAKRSD VYIAGFFPYG DGVENSYTGR GVMPSVKLAL  60
   61 GHVNEHGKIL ANYRLHMWWN DTQCNAAVGV KSFFDMMHSG PNKVMLFGAA CTHVTDPIAK 120
  121 ASKHWHLTQL SYADTHPMFT KDAFPNFFRV VPSENAFNAP RLALLKEFNW TRVGTVYQNE 180
  181 PRYSLPHNHM VADLDAMEVE VVETQSFVND VAESLKKLRE KDVRIILGNF NEHFARKAFC 240
  241 EAYKLDMYGR AYQWLIMATY STDWWNVTQD SECSVEEIAT ALEGAILVDL LPLSTSGDIT 300
  301 VAGITADEYL VEYDRLRGTE YSRFHGYTYD GIWAAALAIQ YVAEKREDLL THFDYRVKDW 360
  361 ESVFLEALRN TSFEGVTGPV RFYNNERKAN ILINQFQLGQ MEKIGEYHSQ KSHLDLSLGK 420
  421 PVKWVGKTPP KDRTLIYIEH SQVNPTIYIV SASASVIGVI IATVFLAFNI KYRNQRYIKM 480
  481 SSPHLNNLII VGCMMTYLSI IFLGLDTTLS SVAAFPYICT ARAWILMAGF SLSFGAMFSK 540
  541 TWRVHSIFTD LKLNKKVIKD YQLFMVVGVL LAIDIAIITT WQIADPFYRE TKQLEPLHHE 600
  601 NIDDVLVIPE NEYCQSEHMT IFVSIIYAYK GLLLVFGAFL AWETRHVSIP ALNDSKHIGF 660
  661 SVYNVFITCL AGAAISLVLS DRKDLVFVLL SFFIIFCTTA TLCLVFVPKL VELKRNPQGV 720
  721 VDKRVRATLR PMSKNGRRDS SVCELEQRLR DVKNTNCRFR KALMEKENEL QALIRKLGPE 780
  781 ARKWIDGVTC TGGSNVGSEL EPILNDDIVR LSAPPVRREM PSTTEVTEMT SVDSVTSTHV 840
  841 EMDNSFVSVQ STVMAPSLPP KKKKQSIVEH HSHAPAPTMM QPIQQQLQQH LQQHQQMQQQ 900
  901 HLQQQQHQQM QQQQQQQQHH HRHLEKRNSV SAQTDDNIGS ITSTAGKRSG GDCSSMRERR 960
  961 QSTASRHYDS GSQTPTARPK YSSSHRNSST NISTSQSELS NMCPHSKPST PAVIKTPTAS1020
 1021 DHRRTSMGSA LKSNFVVSQS DLWDTHTLSH AKQRQSPRNY ASPQRCAEHH GGHGMTYDPN1080
 1081 TTSPIQRSVS EKNRNKHRPK PQKGTVCQSE TDSERERDPP PNSQPCVQPR KVSRSSNIQH1140
 1141 AAHHHSSPNV APDKQRSRQR GKQDSSIYGA SSETELLEGE TAILPIFRKL LTEKSPNYRG1200
 1201 RSAVGQSCPN ISIKCDIVEY L

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..505] PSI-BLAST 77.045757 No description for 2e4uA was found.
    2 View Details [506..575] FFAS03 1.19 Anabaena sensory rhodopsin
    3 View Details [576..712] FFAS03 0.951 Acetylcholine receptor protein, alpha chain
    4 View Details [713..1221] FFAS03 1.08 COLICIN IA


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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