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Protein Overview: r-l-PA

General Information:
Name(s) found: r-l-PA / FBpp0083440 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene rudimentary-like is referred to in FlyBase by the symbol Dmel\r-l (CG3593, FBgn0003257). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:16896275..16899039. It has the cytological map location 93B10. There is experimental evidence that it has the molecular function</span>: orotidine-5'-phosphate decarboxylase activity; orotate phosphoribosyltransferase activity. It is reported to be involved in the biological process</span>: 'de novo' pyrimidine base biosynthetic process. 12 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 493 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: 'de novo' pyrimidine base biosynthetic process [IC][IEA][NAS]
    nucleoside metabolic process [IEA]
    pyrimidine nucleotide biosynthetic process [IEA]
    Molecular Function: orotidine-5'-phosphate decarboxylase activity [IMP][ISS]
    orotate phosphoribosyltransferase activity [IMP][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVAQNSDKMR ALALKLFEIN AFKFGDFKMK VGINSPVYFD LRVIVSYPDV MQTVSDLLVE  60
   61 HIKDKQLSAK HVCGVPYTAL PLATIVSVQQ GTPMLVRRKE AKAYGTKKLV EGIFNAGDTC 120
  121 LIVEDVVTSG SSILDTVRDL QGEGIVVTDA VVVVDREQGG VANIAKHGVR MHSLFTLSFL 180
  181 LNTLHEAGRI EKSTVEAVAK YIAAVQINSD GTFVGGDKGD VVRANDLQRT KLTYENRANL 240
  241 AKSAVAKRLF NLIASKQTNL CLAADLTHAD EILDVADKCG PYICLLKTHV DIVEDFSDKF 300
  301 IADLQALAQR HNFLLMEDRK FADIGNTVSL QYGKGIYKIS SWADLVTAHT LPGRSILQGL 360
  361 KAGLGEGGAG KERGVFLLAE MSASGNLIDA KYKENSNKIA TEGADVDFVA GVVCQSSDAF 420
  421 AFPGLLQLTP GVKIDEGVDQ LGQQYQSPEH VVKERGADIG VVGRGILKAS SPKQAAQTYR 480
  481 DRLWAAYQDR VAK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..214] PSI-BLAST 42.522879 Orotate PRTase
    2 View Details [215..493] PSI-BLAST 77.0 No description for 2eawA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • adenine phosphoribosyltransferase activity
    		•  3.1748712918814 bayes_pls_golite062009
  • uracil phosphoribosyltransferase activity
    		•  3.0470646511978 bayes_pls_golite062009
  • hypoxanthine phosphoribosyltransferase activity
    		•  2.97347277288245 bayes_pls_golite062009
  • transferase activity
    		•  2.73727660668741 bayes_pls_golite062009
  • nucleobase binding
    		•  2.70671399975507 bayes_pls_golite062009
  • transferase activity, transferring pentosyl groups
    		•  2.53679639481311 bayes_pls_golite062009
  • purine binding
    		•  2.50071119798576 bayes_pls_golite062009
  • catalytic activity
    		•  2.30431811394775 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  2.21367942706564 bayes_pls_golite062009
  • orotate phosphoribosyltransferase activity
    		•  2.02298774328915 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.79779416554304 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.57737999906367 bayes_pls_golite062009
  • DNA binding
    		•  1.52807259795452 bayes_pls_golite062009
  • ribose phosphate diphosphokinase activity
    		•  1.51875493459374 bayes_pls_golite062009
  • binding
    		•  1.28428238110443 bayes_pls_golite062009
  • amidophosphoribosyltransferase activity
    		•  0.932396739123353 bayes_pls_golite062009
  • transcription factor activity
    		•  0.899561328226456 bayes_pls_golite062009
  • diphosphotransferase activity
    		•  0.749909396904601 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.429422054980564 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle