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View Structure Prediction Details

Protein: r-l-PA
Organism: Drosophila melanogaster
Length: 493 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for r-l-PA.

Description E-value Query
Range
Subject
Range
gi|340170 - gi|340170|gb|AAA61256.1| orotidine 5'-monophosphate decarboxylase (EC 4.1.1.23) [Homo sapiens]
443.0 [0..16] [492..3]

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Predicted Domain #1
Region A:
Residues: [1-214]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVAQNSDKMR ALALKLFEIN AFKFGDFKMK VGINSPVYFD LRVIVSYPDV MQTVSDLLVE  60
   61 HIKDKQLSAK HVCGVPYTAL PLATIVSVQQ GTPMLVRRKE AKAYGTKKLV EGIFNAGDTC 120
  121 LIVEDVVTSG SSILDTVRDL QGEGIVVTDA VVVVDREQGG VANIAKHGVR MHSLFTLSFL 180
  181 LNTLHEAGRI EKSTVEAVAK YIAAVQINSD GTFV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 42.522879
Match: 1oroA
Description: Orotate PRTase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
adenine phosphoribosyltransferase activity 3.1748712918814 bayes_pls_golite062009
uracil phosphoribosyltransferase activity 3.0470646511978 bayes_pls_golite062009
hypoxanthine phosphoribosyltransferase activity 2.97347277288245 bayes_pls_golite062009
transferase activity 2.73727660668741 bayes_pls_golite062009
nucleobase binding 2.70671399975507 bayes_pls_golite062009
transferase activity, transferring pentosyl groups 2.53679639481311 bayes_pls_golite062009
purine binding 2.50071119798576 bayes_pls_golite062009
catalytic activity 2.30431811394775 bayes_pls_golite062009
transferase activity, transferring glycosyl groups 2.21367942706564 bayes_pls_golite062009
orotate phosphoribosyltransferase activity 2.02298774328915 bayes_pls_golite062009
transcription regulator activity 1.79779416554304 bayes_pls_golite062009
nucleic acid binding 1.57737999906367 bayes_pls_golite062009
DNA binding 1.52807259795452 bayes_pls_golite062009
ribose phosphate diphosphokinase activity 1.51875493459374 bayes_pls_golite062009
binding 1.28428238110443 bayes_pls_golite062009
amidophosphoribosyltransferase activity 0.932396739123353 bayes_pls_golite062009
transcription factor activity 0.899561328226456 bayes_pls_golite062009
diphosphotransferase activity 0.749909396904601 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.429422054980564 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [215-493]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGDKGDVVRA NDLQRTKLTY ENRANLAKSA VAKRLFNLIA SKQTNLCLAA DLTHADEILD  60
   61 VADKCGPYIC LLKTHVDIVE DFSDKFIADL QALAQRHNFL LMEDRKFADI GNTVSLQYGK 120
  121 GIYKISSWAD LVTAHTLPGR SILQGLKAGL GEGGAGKERG VFLLAEMSAS GNLIDAKYKE 180
  181 NSNKIATEGA DVDFVAGVVC QSSDAFAFPG LLQLTPGVKI DEGVDQLGQQ YQSPEHVVKE 240
  241 RGADIGVVGR GILKASSPKQ AAQTYRDRLW AAYQDRVAK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 77.0
Match: 2eawA
Description: No description for 2eawA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle