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Protein Overview: Dys-PB

General Information:
Name(s) found: Dys-PB / FBpp0083180 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene Dystrophin is referred to in FlyBase by the symbol Dmel\Dys (CG34157, FBgn0260003). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:15286810..15421117. It has the cytological map location 92A5-92A10. There is experimental evidence that it has the molecular function</span>: WW domain binding. There is experimental evidence that it is involved in the biological process</span>: neuromuscular synaptic transmission; imaginal disc-derived wing vein morphogenesis; imaginal disc-derived wing vein specification; regulation of short-term neuronal synaptic plasticity; muscle homeostasis; establishment of cell polarity. 39 alleles are reported. The phenotypes of these alleles are annotated with: posterior crossvein; presynaptic active zone; terminal button. It has 8 annotated transcripts and 8 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1669 amino acids

    Gene Ontology:
    Cellular Component: cytoskeleton [ISS]
    dystrophin-associated glycoprotein complex [IPI][ISS][NAS]
    Biological Process: muscle organ development [ISS]
    muscle cell homeostasis [IMP]
    neuromuscular synaptic transmission [IDA]
    establishment of cell polarity [IMP]
    imaginal disc-derived wing vein morphogenesis [IMP]
    imaginal disc-derived wing vein specification [IMP]
    regulation of short-term neuronal synaptic plasticity [IDA]
    Molecular Function: zinc ion binding [IEA]
    structural constituent of muscle [ISS]
    actin binding [ISS]
    calcium ion binding [IEA]
    structural molecule activity [ISS]
    structural constituent of cytoskeleton [ISS]
    cytoskeletal protein binding [ISS]
    WW domain binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTAKPPPPIP PTLGGDDSGT HGPKLAPEIP RINSELAAQA ALRGQQLLRK QGSQEQHATN  60
   61 TLPAHKTGAP PPLPPTQSRP VPAIPARGAS DRAAPPEIPP KRHSLKSMPD GQPMMVPGLP 120
  121 PTMRQPPPLP RKPASTQSSA QNSAQSSPLA GMKFKDKPPP PPEKHSTLSA EGMAARRCSN 180
  181 PFEMPPPPPP LVLQSAVAAL SEQSSKNGLN PVPSPAPTRA SEAKKINQRS IASPTEEFGS 240
  241 EDALRGIESG LRNMERAMQE QMNLRNMEAA VQNNFDLSFK ASLAAGARHL GGGSVNLRTA 300
  301 NYERNLSLDE GRAGDSRQSL EELKQLRAQA QQQSLLNNSS SSSSNSQVEQ SMRSTIEHHM 360
  361 RSLDRNLPLE LQYSRHRFQN NLNAVAAAGG GGGNSSTGNA VANSGTSGSQ QPPMPLSSEF 420
  421 REQIRQQLLG NIPPQVVHNM GQSPGSAAAA ALLQHQAQSR AAAAAAAAAA AAAAAQVAAG 480
  481 SGALSREELR MRRRSSHDET QLTQNSSGGI QVTRLREHWD ETSQCVLQRA AQLKNMLSDS 540
  541 QRFEAKRLEL EKWLARMEQR AERMGTIATT ADILEAQQKE QKSFHAELHQ NKQHFDIFNE 600
  601 LTQKLIAVYP NDDTTRIKKM TEVINQRYAN LNSGVINRGK QLHAAVHSLQ SFDRAMDQFL 660
  661 AFLSETETLC ENAESDIERN PLMFKDLQSE IETHRVVYDR LDGTGRKLLG SLTSQEDAVM 720
  721 LQRRLDEMNQ RWNNLKSKSI AIRNRLESNS EHWNALLLSL RELTEWVIRK DTELSTLGLG 780
  781 PVRGDAVSLQ KQLDDHKAFR RQLEDKRPIV ESNLTSGRQY IANEAAVSDT SDTEANHDSD 840
  841 SRYMSAEEQS RELTRSIRRE VGKLSEQWNN LIDRSDNWKH RLDEYMTKMR QFQKILEDLS 900
  901 SRVALAEQTK TSWLPPSSVG EANEQMQQLQ RLRDKMTTAS ALLDDCNEQQ SFFTANQVLV 960
  961 PTPCLSKLED LNTRMKLLQI AMDERQKVLC QAGAQQTHEN GDDGRTTSNS GTIGPLPNLG1020
 1021 QSVKPPWERA TTAANVPYYI DHERETTHWD HPEMIELMKG LADLNEIRFS AYRTAMKLRS1080
 1081 VQKRLALDRI SMSTACESFD RHGLRAQNDK LIDIPDMTTV LHSLYVTIDK IDLTLMLDLA1140
 1141 INWILNVYDS QRTGQIRVLS FKVGLVLLCK GHLEEKYRYL FRLVADTDRR ADQRRLGLLL1200
 1201 HDCIQVPRQL GEVAAFGGSN IEPSVRSCLE QAGISQEAID GNQDISIELQ HFLGWLQHEP1260
 1261 QSLVWLPVLH RLAAAEAAKH QAKCNICKEY PIVGFRYRCL KCFNFDMCQK CFFFGRNAKN1320
 1321 HKLTHPMHEY CTTTTSTEDV RDFTRALKNK FKSRKYFKKH PRVGYLPVQS VLEGDALESP1380
 1381 APSPQHTTHQ LQNDMHSRLE MYASRLAQVE YGGTGSNSTP DSDDEHQLIA QYCQALPGTS1440
 1441 NGSAPKSPVQ VMAAMDAEQR EELEAIIRDL EEENANLQAE YQQLCSKEQS GMPEDSNGMQ1500
 1501 HSSSSMTGLS GQGEQGQDMM AEAKLLRQHK GRLEARMQIL EDHNRQLEAQ LQRLRQLLDE1560
 1561 PNGGGSSATS SGLPSAPGSA LNSKPNTLQT RSVTASQLNT DSPAKMNQQN GHYEHNSKNS1620
 1621 SGLVTVITEQ ELESINDDLE DSSSSNTTNT TTTTTTTATT EKTCVELQK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..163] PSI-BLAST 6.09691 No description for 1y0fA was found.
    2 View Details [164..413] deduced N/A No confident structure predictions are available.
    3 View Details [414..866] PSI-BLAST 17.39794 Heavy meromyosin subfragment
    4 View Details [867..1102] PSI-BLAST 6.39794 Crystal Structure of Repeats 15, 16 and 17 of Chicken Brain Alpha Spectrin
    5 View Details [1103..1188] PSI-BLAST 5.30103 No description for 2dfsA was found.
    6 View Details [1189..1279] PSI-BLAST 64.69897 Dystrophin
    7 View Details [1280..1372] PSI-BLAST 26.045757 No description for 2e5rA was found.
    8 View Details [1373..1436] deduced N/A No confident structure predictions are available.
    9 View Details [1437..1563] FFAS03 2.02 No description for 2fxmA was found.
    10 View Details [1564..1669] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • structural constituent of muscle
    		•  5.54109779906915 bayes_pls_golite062009
  • acetylcholine transmembrane transporter activity
    		•  4.63361193364389 bayes_pls_golite062009
  • actin binding
    		•  3.96919556235483 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.49668552859347 bayes_pls_golite062009
  • binding
    		•  3.17556402087346 bayes_pls_golite062009
  • microfilament motor activity
    		•  2.9702957313812 bayes_pls_golite062009
  • motor activity
    		•  2.57627414053278 bayes_pls_golite062009
  • actin filament binding
    		•  2.35534489389161 bayes_pls_golite062009
  • myosin binding
    		•  2.34125070430971 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.23156041569913 bayes_pls_golite062009
  • metal ion binding
    		•  2.11094352721028 bayes_pls_golite062009
  • cation binding
    		•  2.11094352721028 bayes_pls_golite062009
  • ion binding
    		•  2.10331783734535 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  2.06646671333275 bayes_pls_golite062009
  • DNA binding
    		•  1.73924929536227 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.53225451586959 bayes_pls_golite062009
  • calcium ion binding
    		•  1.40919295397643 bayes_pls_golite062009
  • protein binding
    		•  1.16246005294206 bayes_pls_golite062009
  • transporter activity
    		•  1.15928534291452 bayes_pls_golite062009
  • actin monomer binding
    		•  0.9954841049256 bayes_pls_golite062009
  • nitric-oxide synthase binding
    		•  0.965098383344279 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.945691505472547 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.933783050059916 bayes_pls_golite062009
  • signal transducer activity
    		•  0.933783050059916 bayes_pls_golite062009
  • amine transmembrane transporter activity
    		•  0.717054504236607 bayes_pls_golite062009
  • tubulin binding
    		•  0.710693016758742 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.693724160233023 bayes_pls_golite062009
  • structural molecule activity
    		•  0.640474644163009 bayes_pls_golite062009
  • myosin heavy chain binding
    		•  0.61866037435065 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.45412801027969 bayes_pls_golite062009
  • myosin II heavy chain binding
    		•  0.308481284245779 bayes_pls_golite062009
  • microtubule binding
    		•  0.278596514315141 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.246383459363256 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.193201281459889 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.116648335890738 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0305250212662123 bayes_pls_golite062009
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.83

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle