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Protein Overview: vib-PA, FBpp0310907

General Information:
Name(s) found: FBpp0310907 [FlyBase]
vib-PA / FBpp0083159 [FlyBase]
Description(s) found:
Found 28 descriptions.
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  • type=protein; loc=3R:complement(15043615..15043753,15043881..15044060,15044124..15044233,15044691..15044768,15044911..15045062,15045127..15045238,15045319..15045349,15051737..15051753); ID=FBpp0310907; name=vib-PC; parent=FBgn0262468,FBtr0344554; dbxref=FlyBase:FBpp0310907,FlyBase_Annotation_IDs:CG5269-PC; MD5=107b02a81a805ce55cea0b48bd53b60f; length=272; release=r5.56; species=Dmel; [FlyBase]
  • The gene vibrator is referred to in FlyBase by the symbol Dmel\vib (CG5269, FBgn0260992). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:15043466..15052373. It has the cytological map location 91F11. Based on sequence similarity, it is predicted to have molecular function</span>: phospholipid transporter activity; phosphoinositide binding. There is experimental evidence that it is involved in the biological process</span>: contractile ring contraction involved in cytokinesis during cell cycle; embryonic development via the syncytial blastoderm; meiotic spindle stabilization; cytokinesis after meiosis II; cytokinesis, contractile ring formation; cytokinesis after meiosis I. 22 alleles are reported. The phenotypes of these alleles are annotated with: Nebenkern; spermatid; spindle; larval brain. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 272 amino acids

    Gene Ontology:
    Cellular Component: cleavage furrow [IDA]
    spindle envelope [IDA]
    Biological Process: contractile ring contraction involved in cell cycle cytokinesis [IMP]
    embryonic development via the syncytial blastoderm [IMP]
    cytokinesis, actomyosin contractile ring assembly [IMP]
    spermatocyte division [IMP]
    cytokinesis after meiosis I [IMP]
    cytokinesis after meiosis II [IMP]
    meiotic spindle stabilization [IMP]
    male meiosis cytokinesis [IMP]
    transport [IEA]
    Molecular Function: phospholipid transporter activity [ISS][NAS]
    phosphoinositide binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQIKEFRVTL PLTVEEYQVA QLFSVAEASK ENTGGGEGIE VLKNEPFEDF PLLGGKYNSG  60
   61 QYTYKIYHLQ SKVPAYIRLL APKGSLEIHE EAWNAYPYCR TIITNPKFMK DAFKIIIDTL 120
  121 HVGDAGDSEN VHELTPDKLK VREIVHIDIA NDPVLPADYK PDEDPTTYQS KKTGRGPLVG 180
  181 SDWKKHVNPV MTCYKLVTCE FKWFGLQTRV ENFIQKSERR LFTNFHRQVF CSTDRWYGLT 240
  241 MEDIRAIEDQ TKEELDKARQ VGEVRGMRAD AD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..272] PSI-BLAST 121.0 Structure of PITP-alpha complexed to phosphatidylinositol

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phospholipid transporter activity
    		•  5.13837461289632 bayes_pls_golite062009
  • lipid transporter activity
    		•  4.4358073696145 bayes_pls_golite062009
  • phosphatidylinositol transporter activity
    		•  2.88424241201993 bayes_pls_golite062009
  • transporter activity
    		•  2.27726025087174 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.15798050058248 bayes_pls_golite062009
  • binding
    		•  2.03322388415011 bayes_pls_golite062009
  • sterol binding
    		•  1.50607153716429 bayes_pls_golite062009
  • cholesterol binding
    		•  1.15123926171731 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.09413284791115 bayes_pls_golite062009
  • phosphatidylcholine transmembrane transporter activity
    		•  0.917631923888787 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.584604660695011 bayes_pls_golite062009
  • cholesterol transporter activity
    		•  0.478721911308239 bayes_pls_golite062009
  • protein binding
    		•  0.43929659331502 bayes_pls_golite062009
  • sterol transporter activity
    		•  0.35901111584592 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.295257921753146 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.286459038638072 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.265156292873733 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.256503527440737 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.21859262454477 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.215063584310921 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.214776368903272 bayes_pls_golite062009
  • lipid binding
    		•  0.144022082146249 bayes_pls_golite062009
  • steroid binding
    		•  0.136743971526566 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0954103313829049 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0415343979510595 bayes_pls_golite062009
  • catalytic activity
    		•  0.0116392906163881 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.00274551209125462 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle