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Protein Overview: endoA-PB, endoA-...

General Information:
Name(s) found: FBpp0306589 [FlyBase]
endoA-PB / FBpp0083113 [FlyBase]
endoA-PA / FBpp0083112 [FlyBase]
Description(s) found:
Found 43 descriptions.
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  • type=protein; loc=3R:14732989..14734098; ID=FBpp0306589; name=EndoA-PC; parent=FBgn0038659,FBtr0334522; dbxref=FlyBase:FBpp0306589,FlyBase_Annotation_IDs:CG14296-PC,REFSEQ:NP_001262717,GB_protein:AGB96097; MD5=1e3737cac61b5f6715c5ff6b65f0baa2; length=369; release=r5.56; species=Dmel; [FlyBase]
  • The gene endophilin A is referred to in FlyBase by the symbol Dmel\endoA (CG14296, FBgn0038659). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:14732332..14736070. It has the cytological map location 91D4. There is experimental evidence that it has the molecular function</span>: lysophosphatidic acid acyltransferase activity. There is experimental evidence that it is involved in the biological process</span>: synaptic vesicle endocytosis; regulation of synapse structure and activity. 18 alleles are reported. The phenotypes of these alleles are annotated with: presynaptic active zone; bouton; motor neuron; larval neuromuscular junction; synapse; synaptic vesicle. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene endophilin A is referred to in FlyBase by the symbol Dmel\endoA (CG14296, FBgn0038659). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:14732332..14736070. It has the cytological map location 91D4. There is experimental evidence that it has the molecular function</span>: lysophosphatidic acid acyltransferase activity. There is experimental evidence that it is involved in the biological process</span>: synaptic vesicle endocytosis; regulation of synapse structure and activity. 18 alleles are reported. The phenotypes of these alleles are annotated with: presynaptic active zone; bouton; motor neuron; larval neuromuscular junction; synapse; synaptic vesicle. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 369 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDA]
    Biological Process: synaptic vesicle endocytosis [IMP][NAS][TAS]
    regulation of synapse structure and activity [IMP]
    neurotransmitter secretion [NAS]
    Molecular Function: lysophosphatidic acid acyltransferase activity [IDA][NAS]
    protein binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAFAGLKKQI NKANQYMTEK MGGAEGTKLD MDFMEMERKT DVTVELVEEL QLKTKEFLQP  60
   61 NPTARAKMAA VKGISKLSGQ AKSNTYPQPE GLLAECMLTY GKKLGEDNSV FAQALVEFGE 120
  121 ALKQMADVKY SLDDNIKQNF LEPLHHMQTK DLKEVMHHRK KLQGRRLDFD CKRRRQAKDD 180
  181 EIRGAEDKFG ESLQLAQVGM FNLLENDTEH VSQLVTFAEA LYDFHSQCAD VLRGLQETLQ 240
  241 EKRSEAESRP RNEFVPKTLL DLNLDGGGGG LNEDGTPSHI SSSASPLPSP MRSPAKSMAV 300
  301 TPQRQQQPCC QALYDFEPEN PGELAFKEND IITLLNRVDD NWFEGAVNGR TGYFPQSYVQ 360
  361 VQVPLPNGN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..259] PSI-BLAST 39.09691 No description for 1x03A was found.
    2 View Details [260..369] PSI-BLAST 17.154902 No description for 2dbmA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein binding
    		•  2.92353432746981 bayes_pls_golite062009
  • binding
    		•  2.43584893484993 bayes_pls_golite062009
  • lysophosphatidic acid acyltransferase activity
    		•  1.43515660906576 bayes_pls_golite062009
  • signal transducer activity
    		•  1.15315260510573 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.15315260510573 bayes_pls_golite062009
  • identical protein binding
    		•  0.652723321884221 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.127423274812986 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.11971814425029 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0898200140309309 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0808236947742297 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.0782188789090384 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle