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Protein Overview: Mekk1-PB

General Information:
Name(s) found: Mekk1-PB / FBpp0083099 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene Mekk1 is referred to in FlyBase by the symbol Dmel\Mekk1 (CG7717, FBgn0024329). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:14558755..14569280. It has the cytological map location 91C5. There is experimental evidence that it has the molecular function</span>: MAP kinase kinase kinase activity. There is experimental evidence that it is involved in the biological process</span>: MAPKKK cascade; response to oxidative stress; protein amino acid phosphorylation; mucosal immune response; response to stress. 24 alleles are reported. The phenotype of these alleles is annotated with: wing. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1571 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: MAPKKK cascade [IDA]
    response to oxidative stress [IMP]
    protein amino acid phosphorylation [IDA][NAS][TAS]
    mucosal immune response [IMP]
    response to stress [IDA][IMP]
    Molecular Function: ATP binding [IEA]
    receptor signaling protein serine/threonine kinase activity [NAS]
    MAP kinase kinase kinase activity [IDA][NAS][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNRRRVRTI DYLALQQSLR LQKTPAATTN AEEQVAREEE NGNGHHSTVT AETPPTPPIP  60
   61 PIPPIRLRRE QSVEEDVARV EYRVKQTPSR PVQMTRNRIG ALEEDMPPED ELAAHYEAFG 120
  121 TTPPRTRLKI KNRDWERKQK VVNVTASADL PASVGGTPKK TRTARSRVLR RNTMDCALLN 180
  181 EMFVNDESKR TDKRLQSLLR DSEREMKNSL ATTAVAAPRG NSFHETAHPL ESLDQIMPLN 240
  241 SEAMAPIPLR IASKVVESCN RYRCVSSRPI GYRSSAPPLA FAAQLPAGML RSDGRATPGL 300
  301 GKRKDFHETF ANLIKLGSVD RQDAKLSQEE HTWQTELKDL IWLELQAWQA DRTVEQQDKY 360
  361 LFEARQGVSD LLTHIINYKF QPRYRREPSL ISLDSGTHSD SNSNASSPLP SKMCQGCMSL 420
  421 YCKDCMDHQE LALREVEGML TRLEAAEALY PSSQAMGALH PIYKSQSFVG RIKSMCLWYN 480
  481 ITKQNKLKLS ILGKILARLQ DEKFSWPVCT SSYIATDSGS SSASGVENDD SAVNSMDSSK 540
  541 PPSMAGSASR KGVTPCHKVQ FMLNDATHVP GETSSSNEST STEVSQWSSE CSHSHMRKGS 600
  601 MHDINIFSVE PLGTCSSNGT GEQSTGLYRK FIENVLKSRG LAKSLAFLHK LHNVALYKAH 660
  661 IALEKPGAED FDYESDAESI EEDVPRLDPE ISREQVVELR TYGYWSEEAQ SINLPSYIPT 720
  721 FVFLSGIPLQ FMHEFLRMRL ETRPVRPNPL SLEQLMKELR EGLTLALTHR ERYQRHITTA 780
  781 LVENEAELGS YISILNHYDA TVRKTFELYL EYIDQLVLVA VPEGNQKSVL EKEWMFTKLI 840
  841 SPMIKGMHTL ASQKFCGIIS KLLRSISERL VKRTVELDQQ IDGTADTDDN EEVKWQLLTI 900
  901 CRETQSLLTV ERERSIKVLF FAKTFCRDVE TTDFHREHYE HDVANQQHDF ICSDVKAAFK 960
  961 LLQQDVLQVR NKLTAIIEGV QKRCCLSNMR DLDEQDKQAV LSRTREILHQ GYKFGFEYHK1020
 1021 DVIRLFEQKI MDQKDSGAHT VDLALGIIAY AKMWMHFVME RCERGRGMRP RWASQGLEFL1080
 1081 ILACDPQITQ HLDDDEFEAL KQQMDRCISH VIGITSEPEK VAKKKASPRT RKTSSPATSR1140
 1141 SRTPTRTPMS AGMVLNPNTP PLQSPPYNKL LHPQFSLKED VSGTSYSPVD SSDYVDTPCQ1200
 1201 RSANGELRLL VPQTPPTPAS PGKSSLESTP LALRQERVRD AVNRLDMDLE DGLRERRLIG1260
 1261 QVKSLNSSDK VHIRARSVHF RWHRGIKIGQ GRFGKVYTAV NNNTGELMAM KEIAIQPGET1320
 1321 RALKNVAEEL KILEGIKHKN LVRYYGIEVH REELLIFMEL CSEGTLESLV ELTGNLPEAL1380
 1381 TRRFTAQLLS GVSELHKHGI VHRDIKTANI FLVDGSNSLK LGDFGSAVKI QAHTTVPGEL1440
 1441 QGYVGTQAYM APEVFTKTNS DGHGRAADIW SVGCVVVEMA SGKRPWAQFD SNFQIMFKVG1500
 1501 MGEKPQAPES LSQEGHDFID HCLQHDPKRR LTAVELLEHN FCKYGRDECS SEQLQMQVRG1560
 1561 SFRRNVATSS S

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..147] deduced N/A No confident structure predictions are available.
    2 View Details [148..384] deduced N/A No confident structure predictions are available.
    3 View Details [385..514] deduced N/A No confident structure predictions are available.
    4 View Details [515..610] deduced N/A No confident structure predictions are available.
    5 View Details [611..684] deduced N/A No confident structure predictions are available.
    6 View Details [685..876] deduced N/A No confident structure predictions are available.
    7 View Details [877..1109] deduced N/A No confident structure predictions are available.
    8 View Details [1110..1224] deduced N/A No confident structure predictions are available.
    9 View Details [1225..1571] PSI-BLAST 75.522879 Catalytic and ubiqutin-associated domains of MARK2/PAR-1: Wild type


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle