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View Structure Prediction Details

Protein: Mekk1-PB
Organism: Drosophila melanogaster
Length: 1571 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Mekk1-PB.

Description E-value Query
Range
Subject
Range
gi|15186734 - gi|15186734|dbj|BAB62891.1| mekk1a [Drosophila melanogaster]
1709.0 [0..1] [1571..1]

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Predicted Domain #1
Region A:
Residues: [1-147]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNRRRVRTI DYLALQQSLR LQKTPAATTN AEEQVAREEE NGNGHHSTVT AETPPTPPIP  60
   61 PIPPIRLRRE QSVEEDVARV EYRVKQTPSR PVQMTRNRIG ALEEDMPPED ELAAHYEAFG 120
  121 TTPPRTRLKI KNRDWERKQK VVNVTAS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [148-384]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ADLPASVGGT PKKTRTARSR VLRRNTMDCA LLNEMFVNDE SKRTDKRLQS LLRDSEREMK  60
   61 NSLATTAVAA PRGNSFHETA HPLESLDQIM PLNSEAMAPI PLRIASKVVE SCNRYRCVSS 120
  121 RPIGYRSSAP PLAFAAQLPA GMLRSDGRAT PGLGKRKDFH ETFANLIKLG SVDRQDAKLS 180
  181 QEEHTWQTEL KDLIWLELQA WQADRTVEQQ DKYLFEARQG VSDLLTHIIN YKFQPRY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [385-514]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RREPSLISLD SGTHSDSNSN ASSPLPSKMC QGCMSLYCKD CMDHQELALR EVEGMLTRLE  60
   61 AAEALYPSSQ AMGALHPIYK SQSFVGRIKS MCLWYNITKQ NKLKLSILGK ILARLQDEKF 120
  121 SWPVCTSSYI 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [515-610]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATDSGSSSAS GVENDDSAVN SMDSSKPPSM AGSASRKGVT PCHKVQFMLN DATHVPGETS  60
   61 SSNESTSTEV SQWSSECSHS HMRKGSMHDI NIFSVE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [611-684]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLGTCSSNGT GEQSTGLYRK FIENVLKSRG LAKSLAFLHK LHNVALYKAH IALEKPGAED  60
   61 FDYESDAESI EEDV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [685-876]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRLDPEISRE QVVELRTYGY WSEEAQSINL PSYIPTFVFL SGIPLQFMHE FLRMRLETRP  60
   61 VRPNPLSLEQ LMKELREGLT LALTHRERYQ RHITTALVEN EAELGSYISI LNHYDATVRK 120
  121 TFELYLEYID QLVLVAVPEG NQKSVLEKEW MFTKLISPMI KGMHTLASQK FCGIISKLLR 180
  181 SISERLVKRT VE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [877-1109]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDQQIDGTAD TDDNEEVKWQ LLTICRETQS LLTVERERSI KVLFFAKTFC RDVETTDFHR  60
   61 EHYEHDVANQ QHDFICSDVK AAFKLLQQDV LQVRNKLTAI IEGVQKRCCL SNMRDLDEQD 120
  121 KQAVLSRTRE ILHQGYKFGF EYHKDVIRLF EQKIMDQKDS GAHTVDLALG IIAYAKMWMH 180
  181 FVMERCERGR GMRPRWASQG LEFLILACDP QITQHLDDDE FEALKQQMDR CIS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [1110-1224]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HVIGITSEPE KVAKKKASPR TRKTSSPATS RSRTPTRTPM SAGMVLNPNT PPLQSPPYNK  60
   61 LLHPQFSLKE DVSGTSYSPV DSSDYVDTPC QRSANGELRL LVPQTPPTPA SPGKS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [1225-1571]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLESTPLALR QERVRDAVNR LDMDLEDGLR ERRLIGQVKS LNSSDKVHIR ARSVHFRWHR  60
   61 GIKIGQGRFG KVYTAVNNNT GELMAMKEIA IQPGETRALK NVAEELKILE GIKHKNLVRY 120
  121 YGIEVHREEL LIFMELCSEG TLESLVELTG NLPEALTRRF TAQLLSGVSE LHKHGIVHRD 180
  181 IKTANIFLVD GSNSLKLGDF GSAVKIQAHT TVPGELQGYV GTQAYMAPEV FTKTNSDGHG 240
  241 RAADIWSVGC VVVEMASGKR PWAQFDSNFQ IMFKVGMGEK PQAPESLSQE GHDFIDHCLQ 300
  301 HDPKRRLTAV ELLEHNFCKY GRDECSSEQL QMQVRGSFRR NVATSSS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 75.522879
Match: 1zmuA
Description: Catalytic and ubiqutin-associated domains of MARK2/PAR-1: Wild type
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle