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Protein Overview: VAChT-PA

General Information:
Name(s) found: VAChT-PA / FBpp0083086 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene VAChT is referred to in FlyBase by the symbol Dmel\VAChT (CG32848, FBgn0015323). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:14531174..14544638. It has the cytological map location 91C1-91C3. It is reported to have molecular function</span>: acetylcholine transmembrane transporter activity; acetylcholine:hydrogen antiporter activity. It is reported to be involved in the biological process</span>: neurotransmitter transport. 6 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic extracoxal depressor muscle 66. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 578 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [IEA][NAS]
    Biological Process: neurotransmitter transport [NAS]
    transmembrane transport [IEA]
    drug transport [IEA]
    Molecular Function: acetylcholine transmembrane transporter activity [NAS]
    acetylcholine:hydrogen antiporter activity [NAS]
    drug transmembrane transporter activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASFQIPVIN LEVREVKDIV WEKIQEPVNQ RRLILVIVSI ALLLDNMLYM VIVPIIPDYL  60
   61 REIGSFDDGP TPPPLRDNIT GKIIPVHHDH HGQDSATGIL FASKAIVQLM VNPFSGGLID 120
  121 KIGYDLPMMI GLTIMFFSTA VFACGSSYSV LFFARSLQGA GSAFADTAGL AMIADRFTEE 180
  181 NERSQALGIA LAFISFGCLV APPFGGALYQ FAGKEVPFLI LALVCLLDGL MLLLVMKPVK 240
  241 EAMKQSKDVQ DQVIPIWRLL MDPYIAVCAG ALTMSNVALA FLEPTISLWM EDNMTTDNWK 300
  301 IGMVWLPAFF PHVLGVVITV KMARKYPQHQ WLMAAGGLAL EGFSCFIIPF CSGYKMLMLP 360
  361 ICVICFGIAL IDTALLPTLG YLVDVRYVSV YGSIYAIADI SYSIAYAVGP IIAGGVVEAI 420
  421 GFTALNFLIA FSNLAYVPVL RKLRNIYDFK PFENEANILM QDPPNKEYQT YVMHDQKPVE 480
  481 GGVKNHLEYG QQYQQEQETN LDDQQYEYQQ QQQGYQQGYQ QDQGYQPGYQ EQGGSYAPQG 540
  541 QPRVANPFQQ QQQQQQQQQQ QVQSRGPAAP ANPFRQGF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..462] PSI-BLAST 40.0 Crystal Structure of the Glycerol-3-Phosphate Transporter from E.Coli
    2 View Details [463..578] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transporter activity
    		•  4.09176719149278 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.59744164024479 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.5865018981083 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  3.54194478414824 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.21266150105753 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.79369588808394 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  1.59419818573076 bayes_pls_golite062009
  • organic acid transmembrane transporter activity
    		•  1.24937104052238 bayes_pls_golite062009
  • secondary active transmembrane transporter activity
    		•  1.22264637452409 bayes_pls_golite062009
  • binding
    		•  1.05701989682533 bayes_pls_golite062009
  • alcohol transmembrane transporter activity
    		•  0.924836669821548 bayes_pls_golite062009
  • polyol transmembrane transporter activity
    		•  0.924836669821548 bayes_pls_golite062009
  • glycerol transmembrane transporter activity
    		•  0.812001619402678 bayes_pls_golite062009
  • symporter activity
    		•  0.74591237387473 bayes_pls_golite062009
  • solute:cation symporter activity
    		•  0.74591237387473 bayes_pls_golite062009
  • cation:sugar symporter activity
    		•  0.143419068761182 bayes_pls_golite062009
  • sugar:hydrogen symporter activity
    		•  0.143419068761182 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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