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Protein Overview: MED17-PA

General Information:
Name(s) found: MED17-PA / FBpp0082980 [FlyBase]
Description(s) found:
Found 26 descriptions.
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  • The gene Mediator complex subunit 17 is referred to in FlyBase by the symbol Dmel\MED17 (CG7957, FBgn0038578). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:14014787..14016987. It has the cytological map location 90F6. There is experimental evidence that it has the molecular function</span>: RNA polymerase II transcription mediator activity; transcription activator binding; transcription coactivator activity. There is experimental evidence that it is involved in the biological process</span>: positive regulation of gene-specific transcription from RNA polymerase II promoter; cellular process; sex comb development; regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter. 7 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 642 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS]
    mediator complex [IDA][ISS]
    Biological Process: transcription from RNA polymerase II promoter [IMP][ISS]
    sex comb development [IGI]
    positive regulation of gene-specific transcription from RNA polymerase II promoter [IMP]
    transcription initiation from RNA polymerase II promoter [ISS]
    cellular process [IMP]
    regulation of transcription from RNA polymerase II promoter [IDA]
    Molecular Function: transcription coactivator activity [IDA]
    RNA polymerase II transcription mediator activity [IMP][ISS]
    transcription activator binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNSVNISVE TTCENQIREI GYDGTELYQP PPTLSESLAK CAARIDFSKT SLDDLKKEEK  60
   61 SAAAAADEDK DATQFQESLW PWDAVRNKLK DALTEICVLS DVISIAKDKR YLVLDPLLEE 120
  121 ADDTKPIVQV YSRKKAISQA AQVLLSGAER LRNAHSEQRN RNVSDFHIEL LRLRQNWRLK 180
  181 KVSNAIIGDL SYRTAGSKFG MSGTFEVTKA EETGDEDTAS SSNSSSSVSG NNGMQLKASS 240
  241 ALRVIVPAEL QGVAYIKVIT QKDQEDLCTA QLNLMGHGPN ITAQVGVWQK TLEFAQNVLF 300
  301 CKELFAQLAR EAIQLQAPIP HVVIGNQIRA TLLPNIQLII SLCHSTTFDS SQPAPINDHD 360
  361 HVLEHSLHQL LREVHYKNSH HPFPHPASAP LGPTKKRMLA GPMAADRETL LDMTKSQTIL 420
  421 EQIIAQAQHI FMRKRTQYVL DTLARDVKDP QIVSHWNAMN SPTMSCVKIN IVTHGYDAIG 480
  481 RTSLVIHVKE RSLKCICRDG RVMRLSYEPQ ELRDLILCQI NSHQISCLIS LARCMSWTVL 540
  541 SNSNHLGIGK VEPLGNASSC LLASPNSDRM IAVQIRCDPQ IDVKVYIARS PRQDFFPSPL 600
  601 VPEKLWENLG GTFKEVRFDK IEGKSFLNKM EFLMASLTSN TA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..123] MSA 2.015969 View MSA. No confident structure predictions are available.
    2 View Details [124..369] deduced N/A No confident structure predictions are available.
    3 View Details [370..535] MSA 1.012968 View MSA. No confident structure predictions are available.
    4 View Details [536..642] MSA 1.010952 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle