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Protein Overview: Brf-PA, Brf-PB

General Information:
Name(s) found: Brf-PB / FBpp0291523 [FlyBase]
Brf-PA / FBpp0082893 [FlyBase]
Description(s) found:
Found 26 descriptions.
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  • The gene Brf is referred to in FlyBase by the symbol Dmel\Brf (CG31256, FBgn0038499). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:13200555..13217054. It has the cytological map location 90A3-90A5. There is experimental evidence that it has the molecular function</span>: transcription factor binding. There is experimental evidence that it is involved in the biological process</span>: regulation of transcription from RNA polymerase III promoter. 6 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene Brf is referred to in FlyBase by the symbol Dmel\Brf (CG31256, FBgn0038499). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:13200555..13217054. It has the cytological map location 90A3-90A5. There is experimental evidence that it has the molecular function</span>: transcription factor binding. There is experimental evidence that it is involved in the biological process</span>: regulation of transcription from RNA polymerase III promoter. 6 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 662 amino acids

    Gene Ontology:
    Cellular Component: transcription factor complex [IPI]
    nucleus [NAS]
    transcription factor TFIIIB complex [ISS]
    Biological Process: positive regulation of transcription [IEA]
    regulation of transcription, DNA-dependent [IEA]
    transcription initiation [IEA]
    regulation of transcription [IEA]
    translational initiation [IEA]
    regulation of transcription from RNA polymerase III promoter [IDA][IPI][ISS]
    Molecular Function: translation initiation factor activity [IEA]
    zinc ion binding [IEA]
    RNA polymerase III transcription factor activity [ISS][NAS]
    transcription factor binding [IPI]
    transcription activator activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTGLKCRNC GSNEIEEDNA RGDRVCMNCG SVLEDSLIVS EVQFEEVGHG AAAIGQFVSA  60
   61 ESSGGATNYG YGKFQVGSGT ESREVTIKKA KKDITLLCQQ LQLSQHYADT ALNFFKMALG 120
  121 RHLTRGRKST HIYAACVYMT CRTEGTSHLL IDISDVQQIC SYELGRTYLK LSHALCINIP 180
  181 SLDPCLYIMR FANRLQLGAK THEVSMTALR IVQRMKKDCM HSGRRPTGLC GAALLIAARM 240
  241 HDFSRTMLDV IGVVKIHEST LRKRLSEFAE TPSGGLTLEE FMTVDLEREQ DPPSFKAARK 300
  301 KDRERIKDMG EHELTELQKE IDAHLEKDLG KYSNSVYRQL TKGKGLSPLS SPSTPNSSSE 360
  361 KDIELEESRQ FIEQSNAEVI KELIAKNEDV KKSEPGGLVA GIEGLRPDIE AICRVTQSDL 420
  421 EDVEKAKQPQ EQELITDDLN DDELDQYVLT EEESVAKLEM WKNLNAEYLQ EQKERDERLA 480
  481 KEREEGKPER KKRKPRKKVI GPSSTAGEAI EKMLQEKKIS SKINYEILKT LTDGMGGLTD 540
  541 DSPTTSADTK PSTLEELKHQ PVIVEEGPVA SKSRGNRAAY DLPGPSRKRP KLEVGLPVSK 600
  601 AADVEQAETK PAVVVEADDL DEDADDPDVE PEAEPEATLQ DMLNTGGDDD EFGYGFDEEE 660
  661 EY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..70] FFAS03 2.67 RDC-derived models of the zinc ribbon domain of human general transcription TFIIB (zinc bound structures)
    2 View Details [71..283] PSI-BLAST 62.045757 Transcription factor IIB (TFIIB), core domain
    3 View Details [284..417] deduced N/A No confident structure predictions are available.
    4 View Details [418..488] FFAS03 2.39 TBP-binding domain of the transcription factor IIIb Brf1 subunit
    5 View Details [489..662] MSA 8.221996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • nucleic acid binding
    		•  2.22680674586367 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle