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Protein Overview: Ubx-PA

General Information:
Name(s) found: Ubx-PA / FBpp0082793 [FlyBase]
Description(s) found:
Found 28 descriptions.
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  • The gene Ultrabithorax is referred to in FlyBase by the symbol Dmel\Ubx (CG10388, FBgn0003944). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:12482098..12560348. It has the cytological map location 89D6-89D9. There is experimental evidence that it has the molecular function</span>: protein binding; sequence-specific DNA binding; transcription repressor activity; protein domain specific binding; DNA binding. There is experimental evidence that it is involved in the biological process</span>: specification of segmental identity, thorax; heart development; specification of organ identity; positive regulation of muscle organ development; mesodermal cell fate specification; haltere development; regulation of transcription; imaginal disc-derived leg morphogenesis; regulation of imaginal disc growth; open tracheal system development. 464 alleles are reported. The phenotypes of these alleles are annotated with 108 unique terms, many of which group under: adult segment; organ system; adult mesothoracic segment; thoracic segment; peripheral nervous system; nervous system; larval abdominal segment; embryonic nervous system; organ system subdivision; integumentary plate. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 389 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][ISS][NAS]
    Biological Process: imaginal disc-derived leg morphogenesis [IMP]
    midgut development [TAS]
    specification of segmental identity, thorax [IMP][NAS]
    specification of organ identity [IMP]
    specification of segmental identity, abdomen [NAS]
    dorsal vessel aortic cell fate commitment [TAS]
    haltere development [IMP]
    positive regulation of muscle organ development [IMP]
    regulation of transcription, DNA-dependent [IEA][NAS]
    regulation of transcription [IDA][IEA]
    regulation of transcription from RNA polymerase II promoter [ISS]
    mesodermal cell fate specification [IMP]
    open tracheal system development [IMP]
    heart development [IEP][IMP]
    regulation of imaginal disc growth [IMP]
    endoderm formation [TAS]
    Molecular Function: DNA binding [IDA]
    protein domain specific binding [IPI]
    transcription factor activity [IEA][TAS]
    protein binding [IDA][IPI]
    specific RNA polymerase II transcription factor activity [ISS][NAS]
    sequence-specific DNA binding [IDA]
    transcription repressor activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSYFEQASG FYGHPHQATG MAMGSGGHHD QTASAAAAAY RGFPLSLGMS PYANHHLQRT  60
   61 TQDSPYDASI TAACNKIYGD GAGAYKQDCL NIKADAVNGY KDIWNTGGSN GGGGGGGGGG 120
  121 GGGAGGTGGA GNANGGNAAN ANGQNNPAGG MPVRPSACTP DSRVGGYLDT SGGSPVSHRG 180
  181 GSAGGNVSVS GGNGNAGGVQ SGVGVAGAGT AWNANCTISG AAAQTAAASS LHQASNHTFY 240
  241 PWMAIAGECP EDPTKSKIRS DLTQYGGIST DMGKRYSESL AGSLLPDWLG TNGLRRRGRQ 300
  301 TYTRYQTLEL EKEFHTNHYL TRRRRIEMAH ALCLTERQIK IWFQNRRMKL KKEIQAIKEL 360
  361 NEQEKQAQAQ KAAAAAAAAA AVQGGHLDQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..198] MSA 2.352995 View MSA. No confident structure predictions are available.
    2 View Details [199..282] deduced N/A No confident structure predictions are available.
    3 View Details [283..389] PSI-BLAST 21.69897 Ultrabithorax (ubx) homeodomain


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle