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Protein Overview: CSN5-PA

General Information:
Name(s) found: CSN5-PA / FBpp0082743 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene COP9 complex homolog subunit 5 is referred to in FlyBase by the symbol Dmel\CSN5 (CG14884, FBgn0027053). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:12295823..12297128. It has the cytological map location 89B17. There is experimental evidence that it has the molecular function</span>: protein binding; NEDD8 activating enzyme activity. There is experimental evidence that it is involved in the biological process</span>: positive regulation of cell cycle; protein deneddylation; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; oocyte anterior/posterior axis specification; compound eye photoreceptor cell differentiation; glial cell migration; protein stabilization; multicellular organismal development; axonogenesis; oocyte dorsal/ventral axis specification. 31 alleles are reported. The phenotypes of these alleles are annotated with: lamina anlage glial cell; larva; pupa; ovary; larval optic neuropil; germarium; melanotic mass; dorsal appendage; nurse cell. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 327 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDA]
    signalosome [IDA][IMP][ISS][NAS][TAS]
    Biological Process: compound eye photoreceptor cell differentiation [IMP][TAS]
    multicellular organismal development [IMP]
    oogenesis [TAS]
    axonogenesis [IMP]
    protein deneddylation [IMP]
    positive regulation of cell cycle [IMP]
    oocyte dorsal/ventral axis specification [IMP]
    protein stabilization [IMP]
    glial cell migration [IMP]
    oocyte anterior/posterior axis specification [IMP]
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
    Molecular Function: protein binding [IPI]
    NEDD8 activating enzyme activity [IMP]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSDAAQKTW ELENNIQTLP SCDEIFRYDA EQQRQIIDAK PWEKDPHFFK DIKISALALL  60
   61 KMVMHARSGG TLEVMGLMLG KVEDNTMIVM DAFALPVEGT ETRVNAQAQA YEYMTAYMEA 120
  121 AKEVGRMEHA VGWYHSHPGY GCWLSGIDVS TQMLNQTYQE PFVAIVVDPV RTVSAGKVCL 180
  181 GAFRTYPKGY KPPNEEPSEY QTIPLNKIED FGVHCKQYYP LEISYFKSAL DRRLLDSLWN 240
  241 KYWVNTLGSS GLLTNTEYTT GQIMDLSEKL EQSENFLGRG TDVNEKRSED KLSKATRDCS 300
  301 RSTIELIHGL MAQIVKDKLF NKVGLGK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..199] PSI-BLAST 32.522879 No description for 2o95A was found.
    2 View Details [200..327] MSA 6.243995 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle