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Protein Overview: Pak3-PB

General Information:
Name(s) found: Pak3-PB / FBpp0082764 [FlyBase]
Description(s) found:
Found 12 descriptions.
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  • The gene Pak3 is referred to in FlyBase by the symbol Dmel\Pak3 (CG14895, FBgn0044826). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:12272450..12279550. It has the cytological map location 89B16-89B17. It is reported to have molecular function</span>: receptor signaling protein serine/threonine kinase activity. There is experimental evidence that it is involved in the biological process</span>: actin filament organization. 13 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 405 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: actin filament organization [IMP]
    protein amino acid phosphorylation [IEA][NAS]
    Molecular Function: ATP binding [IEA]
    receptor signaling protein serine/threonine kinase activity [NAS]
    protein serine/threonine kinase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFTKWFKKK GGDGGSISEI GAPTNFQRHF HVSRNQETGD LEGLPAPWVR LMNSQITRDE  60
   61 QDKNPDAAYH AVKYYNYSIK KKENEVFKPF ITEDTILRRS KEKRAQKTDA EIYVELRAIC 120
  121 NSDDPRERYK TTQEVGKGAS GIVFIAADLQ NESQVAVKTI DMKNQSSKDL ILTEIRVLKD 180
  181 FNHKNLVNFL DAYLLEPEDQ LWVVMEYMDG GPLTDVVTET VMKERQIACV CRETLYAISF 240
  241 LHAKGIIHRD IKSDNVLLGM DGSVKVTDFG FCANIEGDEK RQTMVGTPYW MAPEVVTRKK 300
  301 YGKKVDIWSI GIMAIEMIEG QPPYLYETPL RALYLIAANG RPDIKSWDKL SPNLQDFLDR 360
  361 CLQVEVDRRA TADELLSHPF LNDCSEVKAL VPNIKAAKKV LRRNV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..107] PSI-BLAST 3.69897 Growth factor receptor-bound protein 2 (GRB2), N- and C-terminal domains; Growth factor receptor-bound protein 2 (GRB2)
    2 View Details [108..405] PSI-BLAST 79.045757 pak1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  3.12724619324809 bayes_pls_golite062009
  • protein binding
    		•  2.14586566310919 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.85015570449703 bayes_pls_golite062009
  • kinase activity
    		•  1.78069536883109 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.59739467025045 bayes_pls_golite062009
  • protein kinase activity
    		•  1.4654611643382 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.33740973673697 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.2323381312171 bayes_pls_golite062009
  • transferase activity
    		•  1.19152443245584 bayes_pls_golite062009
  • signal transducer activity
    		•  0.999269271132931 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.999269271132931 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.540818657754841 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.476094076158571 bayes_pls_golite062009
  • protein phosphorylated amino acid binding
    		•  0.43808715710519 bayes_pls_golite062009
  • DNA binding
    		•  0.281643350069021 bayes_pls_golite062009
  • phosphoprotein binding
    		•  0.16798254471727 bayes_pls_golite062009
  • kinase regulator activity
    		•  0.10704587503284 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle