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View Structure Prediction Details

Protein: Pak3-PB
Organism: Drosophila melanogaster
Length: 405 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Pak3-PB.

Description E-value Query
Range
Subject
Range
gi|109108029 - gi|109108029|ref|XP_001089846.1| PREDICTED: similar to p21-activated kinase 1 isoform 4 [Macaca mula...
321.0 [0..1] [404..141]

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Predicted Domain #1
Region A:
Residues: [1-107]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFTKWFKKK GGDGGSISEI GAPTNFQRHF HVSRNQETGD LEGLPAPWVR LMNSQITRDE  60
   61 QDKNPDAAYH AVKYYNYSIK KKENEVFKPF ITEDTILRRS KEKRAQK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.69897
Match: 1griA
Description: Growth factor receptor-bound protein 2 (GRB2), N- and C-terminal domains; Growth factor receptor-bound protein 2 (GRB2)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 3.12724619324809 bayes_pls_golite062009
protein binding 2.14586566310919 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.85015570449703 bayes_pls_golite062009
kinase activity 1.78069536883109 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.59739467025045 bayes_pls_golite062009
protein kinase activity 1.4654611643382 bayes_pls_golite062009
molecular adaptor activity 1.33740973673697 bayes_pls_golite062009
SH3/SH2 adaptor activity 1.2323381312171 bayes_pls_golite062009
transferase activity 1.19152443245584 bayes_pls_golite062009
signal transducer activity 0.999269271132931 bayes_pls_golite062009
molecular transducer activity 0.999269271132931 bayes_pls_golite062009
protein binding, bridging 0.83823250804321 bayes_pls_golite062009
transcription regulator activity 0.540818657754841 bayes_pls_golite062009
nucleic acid binding 0.476094076158571 bayes_pls_golite062009
protein phosphorylated amino acid binding 0.43808715710519 bayes_pls_golite062009
DNA binding 0.281643350069021 bayes_pls_golite062009
phosphoprotein binding 0.16798254471727 bayes_pls_golite062009
kinase regulator activity 0.10704587503284 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [108-405]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TDAEIYVELR AICNSDDPRE RYKTTQEVGK GASGIVFIAA DLQNESQVAV KTIDMKNQSS  60
   61 KDLILTEIRV LKDFNHKNLV NFLDAYLLEP EDQLWVVMEY MDGGPLTDVV TETVMKERQI 120
  121 ACVCRETLYA ISFLHAKGII HRDIKSDNVL LGMDGSVKVT DFGFCANIEG DEKRQTMVGT 180
  181 PYWMAPEVVT RKKYGKKVDI WSIGIMAIEM IEGQPPYLYE TPLRALYLIA ANGRPDIKSW 240
  241 DKLSPNLQDF LDRCLQVEVD RRATADELLS HPFLNDCSEV KALVPNIKAA KKVLRRNV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 79.045757
Match: 1f3mC
Description: pak1
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
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