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Protein Overview: Rbf2-PA

General Information:
Name(s) found: Rbf2-PA / FBpp0082667 [FlyBase]
Description(s) found:
Found 24 descriptions.
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  • The gene Retinoblastoma-family protein 2 is referred to in FlyBase by the symbol Dmel\Rbf2 (CG5083, FBgn0038390). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:11791173..11793860. It has the cytological map location 89A8. There is experimental evidence that it has the molecular function</span>: promoter binding. There is experimental evidence that it is involved in the biological process</span>: negative regulation of transcription from RNA polymerase II promoter. 10 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 783 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS]
    Rb-E2F complex [TAS]
    Myb complex [IDA]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [IGI]
    regulation of cell cycle [ISS]
    Molecular Function: DNA binding [ISS]
    promoter binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METCEVEGEA ETLVRRFSVS CEQLELEARI QQSALSTYHR LDAVNGLSTS EADAQEWLCC  60
   61 AVYSELQRSK MRDIRESINE ANDSVAKNCC WNVSLTRLLR SFKMNVSQFL RRMEHWNWLT 120
  121 QNENTFQLEV EELRCRLGIT STLLRHYKHI FRSLFVHPGK GADPGAANHY QALYEFGWLL 180
  181 FLVIRNELPG FAITNLINGC QVLVCTMDLL FVNALEVPRS VVIRREFSGV PKNWDTEDFN 240
  241 PILLNKYSVL EALGELIPEL PAKGVVQMKN AFFHKALIML YMDHSLVGDD THMREIIKEG 300
  301 MLDINLENLN RKYTNQVADI SEMDERVLLS VQGAIETKGD SPKSPQLAFQ TSSSPSHRKL 360
  361 STHDLPASLP LSIIKAFPKK EDADKIVNYL DQTLEEMNRT FTMAVKDFLD AELSGKRFRQ 420
  421 ARGLYYKYLQ KILGPELVQK PQLKIGQLMK QRKLTAALLA CCLELALHVH HKLVEGLRFP 480
  481 FVLHCFSLDA YDFQKILELV VRYDHGFLGR ELIKHLDVVE EMCLDSLIFR KSSQLWWELN 540
  541 QRLPRYKEVD AETEDKENFS TGSSICLRKF YGLANRRLLL LCKSLCLVDS FPQIWHLAEH 600
  601 SFTLESSRLL RNRHLDQLLL CAIHLHVRLE KLHLTFSMII QHYRRQPHFR RSAYREVSLG 660
  661 NGQTADIITF YNSVYVQSMG NYGRHLECAQ TRKSLEESQS NVGILTETTS NELSMRANIS 720
  721 ISSPPPPRVC QSGSCSSHPP SSPAASPLSL QSSPNVKRAA SSNDLMREIK RPNILRRRQL 780
  781 SVI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..168] PSI-BLAST 38.69897 Transcription factor IIB (TFIIB), core domain
    2 View Details [169..303] MSA 1.049995 View MSA. No confident structure predictions are available.
    3 View Details [304..363] deduced N/A No confident structure predictions are available.
    4 View Details [364..702] PSI-BLAST 119.0 No description for 2r7gA was found.
    5 View Details [703..783] MSA 1.030996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • cyclin-dependent protein kinase regulator activity
    		•  4.0678067833198 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  3.72590522082801 bayes_pls_golite062009
  • protein kinase regulator activity
    		•  3.60228514328814 bayes_pls_golite062009
  • kinase regulator activity
    		•  3.4358680585811 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.795846725429 bayes_pls_golite062009
  • binding
    		•  2.4204867358489 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.04886889839181 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.00665312545368 bayes_pls_golite062009
  • DNA binding
    		•  1.94297811210385 bayes_pls_golite062009
  • protein binding
    		•  1.47106731485576 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.42956126861466 bayes_pls_golite062009
  • transcription factor activity
    		•  1.21921365719206 bayes_pls_golite062009
  • transcription factor binding
    		•  0.749278791251235 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.729629809946521 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.138191616709499 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0696060248241566 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle