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Protein Overview: Gyc88E-PC

General Information:
Name(s) found: Gyc88E-PC / FBpp0082487 [FlyBase]
Description(s) found:
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  • gi|75016128|sp|Q8INF0.3|GCY8E_DROME RecName: Full=Soluble guanylate cyclase 88E [NCBI NR]
  • gi|62484298|ref|NP_650424.3| guanylyl cyclase at 88E, isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|61679338|gb|AAN13628.3| guanylyl cyclase at 88E, isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|34980252|gb|AAQ84039.1| guanylyl cyclase long variant [Drosophila melanogaster] [NCBI NR]
  • Soluble guanylate cyclase 88E OS=Drosophila melanogaster GN=Gyc88E PE=1 SV=3 [Swiss-Prot]
  • The gene Guanylyl cyclase at 88E is referred to in FlyBase by the symbol Dmel\Gyc88E (CG4154, FBgn0038295). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:11009908..11016964. It has the cytological map location 88E2. There is experimental evidence that it has the molecular function</span>: guanylate cyclase activity. It is reported to be involved in the biological process</span>: cGMP biosynthetic process. 3 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • >CG4154-PC translation from_gene[CG4154 CG4154 FBgn0038295] seq_release:3 mol_weight=105048 cds_boundaries:(3R:11,011,820..11,015,319[+]) aa_length:947 transcript_info:[CG4154-RC seq_release:3] gene_info:[gene symbol:CG4154 FBgn0038295 gene_boundaries: [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q8INF0) CG4154-PC [DrosMelano7227.FASTAC.txt]
  • guanylyl cyclase long variant [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:join(11011802..11011969,11012035..11012314,11012369..11012576,11012641..11012764,11012820..11012952,11013080..11013306,11013369..11013473,11013544..11013690,11013748..11013898,11013953..11015015,11015067..11015304); ID=FBpp0082487; na [fly-100309-contam.fasta]
  • Guanylyl cyclase at 88E CG4154-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG4154-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Soluble guanylate cyclase 88E [nr-271106-contam.fasta]
  • type=protein; loc=3R:join(11011802..11011969,11012035..11012314,11012369..11012576,11012641..11012764,11012820..11012952,11013080..11013306,11013369..11013473,11013544..11013690,11013748..11013898,11013953..11015015,11015067..11015304); ID=FBpp0082487; name=Gyc88E-PC; parent=FBgn0038295,FBtr0083028; dbxref=GB_protein:AAN13628.2,FlyBase_Annotation_IDs:CG4154-PC,FlyBase:FBpp0082487,GB_protein:AAN13628.3,REFSEQ:NP_650424,GB_protein:AAN13628; MD5=477e39fd1d06a1373e8e9cc8360a848d; length=947; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:join(11011802..11011969,11012035..11012314,11012369..11012576,11012641..11012764,11012820..11012952,11013080..11013306,11013369..11013473,11013544..11013690,11013748..11013898,11013953..11015015,11015067..11015304); ID=FBpp0082487; name=Gyc88E-PC; parent=FBgn0038295,FBtr0083028; dbxref=GB_protein:AAN13628.2,FlyBase_Annotation_IDs:CG4154-PC,FlyBase:FBpp0082487,GB_protein:AAN13628.3,REFSEQ:NP_650424,GB_protein:AAN13628; MD5=477e39fd1d06a1373e8e9cc8360a848d; length=947; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=3R:join(11011802..11011969,11012035..11012314,11012369..11012576,11012641..11012764,11012820..11012952,11013080..11013306,11013369..11013473,11013544..11013690,11013748..11013898,11013953..11015015,11015067..11015304); ID=FBpp0082487; name=Gyc88E-PC; parent=FBgn0038295,FBtr0083028; dbxref=GB_protein:AAN13628.2,FlyBase_Annotation_IDs:CG4154-PC,FlyBase:FBpp0082487,GB_protein:AAN13628.3,REFSEQ:NP_650424,GB_protein:AAN13628,FlyMine:FBpp0082487,modMine:FBpp0082487; MD5=477e39fd1d06a1373e8e9cc8360a848d; length=947; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
    • Organism: Drosophila melanogaster
    Length: 947 amino acids

    Gene Ontology:
    Cellular Component: guanylate cyclase complex, soluble [ISS]
    Biological Process: cGMP biosynthetic process [IC][IEA]
    intracellular signaling pathway [IEA]
    Molecular Function: guanylate cyclase activity [IDA][ISS][NAS]
    heme binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYGLLLENLS EYIKSVYGEE KWEDIRRQAG IDSPSFSVHQ VYPENLLQKL AKKAQQVLGV  60
   61 SERDFMDQMG VYFVGFVGQY GYDRVLSVLG RHMRDFLNGL DNLHEYLKFS YPRMRAPSFI 120
  121 CENETKQGLT LHYRSKRRGF VYYTMGQIRE VARYFYHKEM HIELVREEIL FDTVHVTFQL 180
  181 TFDNRAFTLA SLAMTREEKH LPISAHVLFE IFPFCMVFGA DMVVRSIGNS LMVILPELLG 240
  241 KKITAWFDLV RPLIAFKFQT ILNRTNNIFE LVTVDPVTER FDVQNEDLLQ HEDGSEPEKS 300
  301 LRLKGQMVYM ENWRMIMFLG TPVMPDLTSL ITTGLYINDL SMHDFSRDLM LAGTQQSVEL 360
  361 KLALDQEQQK SKKLEESMRL LDEEMRRTDE LLYQMIPKQV ADRLRRGENP IDTCEMFDSV 420
  421 SILFSDIVTF TEICSRITPM EVVSMLNAMY SIFDKLTERN SVYKVETIGD AYMVVAGAPD 480
  481 KDANHAERVC DMALDMVDAI TDLKDPSTGQ HLRIRVGVHS GAVVAGIVGL KMPRYCLFGD 540
  541 TVNTASRMES TSIAMKVHIS ESTKVLIGPN YKIIERGEID VKGKGTMGTY WLEERENRLP 600
  601 LQLTAALQVH PLSPVPPTPT PKTKAIMPPV SKPLTPMMPV SVSLAASMPT SNVPAVDVMA 660
  661 SSSSISGLAL TAAAAAHMSL HHQAVVAEAL TGASVEVALP SVASGATGAA AGGGAPSDDR 720
  721 NSRIYSPVTF KDVARRSVAN SPVRSCAQPD QERRRESRSN STGHVFMRTP SEIFGSLILD 780
  781 TEEFLEDLQI SRSSLANNNN NQSPCGFSPT PPFRIGSAPP KPRPSNPDKF TPEELAAMDQ 840
  841 LTPPSTAPAR ETASCSSASL DRDKATKLKK ITFSNSSSLD ATTPTALAAV VCPMRTKSPP 900
  901 MAVAPVMHMV QASTSKGDGQ RPGSKDSVSS ISLHSPPPHR SNSAPAR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..184] PSI-BLAST 43.0 No description for 2o09A was found.
    2 View Details [185..410] Pfam 35.638272 No description for PF07701.5 was found. No confident structure predictions are available.
    3 View Details [411..600] PSI-BLAST 59.30103 Adenylyl cyclase VC1, domain C1a
    4 View Details [601..711] deduced N/A No confident structure predictions are available.
    5 View Details [712..947] MSA 15.255997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • guanylate cyclase activity
    		•  10.3848465380008 bayes_pls_golite062009
  • cyclase activity
    		•  9.56622318762576 bayes_pls_golite062009
  • phosphorus-oxygen lyase activity
    		•  9.13872073463964 bayes_pls_golite062009
  • adenylate cyclase activity
    		•  2.79108987859397 bayes_pls_golite062009
  • signal transducer activity
    		•  1.32485567900717 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.32485567900717 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.12394944257466 bayes_pls_golite062009
  • protein binding
    		•  0.835166604872659 bayes_pls_golite062009
  • binding
    		•  0.407021407526425 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.68

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle