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View Structure Prediction Details

Protein: Gyc88E-PC
Organism: Drosophila melanogaster
Length: 947 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Gyc88E-PC.

Description E-value Query
Range
Subject
Range
FBpp0297355, Gyc... - The gene Guanylyl cyclase at 88E is referred to in FlyBase by the symbol Dmel\Gyc88E (CG4154, FBgn00...
699.0 [0..1] [947..1]

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Predicted Domain #1
Region A:
Residues: [1-184]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYGLLLENLS EYIKSVYGEE KWEDIRRQAG IDSPSFSVHQ VYPENLLQKL AKKAQQVLGV  60
   61 SERDFMDQMG VYFVGFVGQY GYDRVLSVLG RHMRDFLNGL DNLHEYLKFS YPRMRAPSFI 120
  121 CENETKQGLT LHYRSKRRGF VYYTMGQIRE VARYFYHKEM HIELVREEIL FDTVHVTFQL 180
  181 TFDN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 43.0
Match: 2o09A
Description: No description for 2o09A was found.

Predicted Domain #2
Region A:
Residues: [185-410]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RAFTLASLAM TREEKHLPIS AHVLFEIFPF CMVFGADMVV RSIGNSLMVI LPELLGKKIT  60
   61 AWFDLVRPLI AFKFQTILNR TNNIFELVTV DPVTERFDVQ NEDLLQHEDG SEPEKSLRLK 120
  121 GQMVYMENWR MIMFLGTPVM PDLTSLITTG LYINDLSMHD FSRDLMLAGT QQSVELKLAL 180
  181 DQEQQKSKKL EESMRLLDEE MRRTDELLYQ MIPKQVADRL RRGENP

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 35.638272
Match: PF07701.5
Description: No description for PF07701.5 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [411-600]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IDTCEMFDSV SILFSDIVTF TEICSRITPM EVVSMLNAMY SIFDKLTERN SVYKVETIGD  60
   61 AYMVVAGAPD KDANHAERVC DMALDMVDAI TDLKDPSTGQ HLRIRVGVHS GAVVAGIVGL 120
  121 KMPRYCLFGD TVNTASRMES TSIAMKVHIS ESTKVLIGPN YKIIERGEID VKGKGTMGTY 180
  181 WLEERENRLP 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 59.30103
Match: 1cjkA
Description: Adenylyl cyclase VC1, domain C1a
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
guanylate cyclase activity 10.3848465380008 bayes_pls_golite062009
cyclase activity 9.56622318762576 bayes_pls_golite062009
phosphorus-oxygen lyase activity 9.13872073463964 bayes_pls_golite062009
adenylate cyclase activity 2.79108987859397 bayes_pls_golite062009
signal transducer activity 1.32485567900717 bayes_pls_golite062009
molecular transducer activity 1.32485567900717 bayes_pls_golite062009
transcription regulator activity 1.12394944257466 bayes_pls_golite062009
protein binding 0.835166604872659 bayes_pls_golite062009
binding 0.407021407526425 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [601-711]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LQLTAALQVH PLSPVPPTPT PKTKAIMPPV SKPLTPMMPV SVSLAASMPT SNVPAVDVMA  60
   61 SSSSISGLAL TAAAAAHMSL HHQAVVAEAL TGASVEVALP SVASGATGAA A

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [712-947]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGGAPSDDRN SRIYSPVTFK DVARRSVANS PVRSCAQPDQ ERRRESRSNS TGHVFMRTPS  60
   61 EIFGSLILDT EEFLEDLQIS RSSLANNNNN QSPCGFSPTP PFRIGSAPPK PRPSNPDKFT 120
  121 PEELAAMDQL TPPSTAPARE TASCSSASLD RDKATKLKKI TFSNSSSLDA TTPTALAAVV 180
  181 CPMRTKSPPM AVAPVMHMVQ ASTSKGDGQR PGSKDSVSSI SLHSPPPHRS NSAPAR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle