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Protein Overview: Art6-PA

General Information:
Name(s) found: Art6-PA / FBpp0082341 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene Arginine methyltransferase 6 is referred to in FlyBase by the symbol Dmel\Art6 (CG9927, FBgn0038189). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:9770376..9771534. It has the cytological map location 88A2. Based on sequence similarity, it is predicted to have molecular function</span>: protein-arginine N-methyltransferase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: protein amino acid methylation. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 341 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEA]
    Biological Process: protein amino acid methylation [IEA]
    Molecular Function: protein-arginine N-methyltransferase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFNANQKLP FLEGKDSDYF QSYSRLETHM NMLRDSVRMQ AFRDAIVQDG GLFQDKIVLD  60
   61 VGCGTGILSL FAAEAGASKV IAVECTDIAD IAEEIIRDNQ KENVVKVVKG LVEQVELPDG 120
  121 IEKVDIIVSE WMGNALYMEA MINSVLFARD KWLTRGGRIL PSTGNLWLMG AYDPHRRTNL 180
  181 NFWCNVEGID MGCVRKPFSQ EPLVEFVPIQ QLLTDECFIH STNLAVARNQ PVEFQSNFQL 240
  241 KVMRTGIINM LVLYFDVLFP SGKSNKSVSL TTSPHSPWTH WEQTVLHLDE PLYVRIRDRV 300
  301 RGVLAMTPTG QDGRGMNFDL HISFRGERTR VESFKSFSSP R

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..341] PSI-BLAST 75.0 Structure of the Predominant protein arginine methyltransferase PRMT1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein-arginine N-methyltransferase activity
    		•  5.52520020727046 bayes_pls_golite062009
  • arginine N-methyltransferase activity
    		•  5.52520020727046 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  5.03267617653315 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  4.4632173842967 bayes_pls_golite062009
  • histone methyltransferase activity (H4-R3 specific)
    		•  4.42061797259061 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  4.40911163698179 bayes_pls_golite062009
  • protein-arginine omega-N monomethyltransferase activity
    		•  4.39379274790202 bayes_pls_golite062009
  • methyltransferase activity
    		•  4.15445027778357 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  4.07806017452628 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  4.07153733729662 bayes_pls_golite062009
  • protein-arginine omega-N asymmetric methyltransferase activity
    		•  3.55785970363721 bayes_pls_golite062009
  • protein-arginine omega-N symmetric methyltransferase activity
    		•  3.42560739702664 bayes_pls_golite062009
  • transferase activity
    		•  2.926540904444 bayes_pls_golite062009
  • histone-arginine N-methyltransferase activity
    		•  2.86617323549909 bayes_pls_golite062009
  • histone methyltransferase activity (H3-R2 specific)
    		•  2.26179395735928 bayes_pls_golite062009
  • histone methyltransferase activity (H2A-R3 specific)
    		•  2.26179395735928 bayes_pls_golite062009
  • DNA-methyltransferase activity
    		•  2.18991764495147 bayes_pls_golite062009
  • [myelin basic protein]-arginine N-methyltransferase activity
    		•  2.10091845446893 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.0187748912503 bayes_pls_golite062009
  • DNA binding
    		•  1.86585662505513 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.71901340148111 bayes_pls_golite062009
  • catalytic activity
    		•  1.25333584501255 bayes_pls_golite062009
  • signal transducer activity
    		•  1.11388181877851 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.11388181877851 bayes_pls_golite062009
  • binding
    		•  0.976078016260105 bayes_pls_golite062009
  • histone binding
    		•  0.964746527369069 bayes_pls_golite062009
  • protein-lysine N-methyltransferase activity
    		•  0.858129308056814 bayes_pls_golite062009
  • lysine N-methyltransferase activity
    		•  0.858129308056814 bayes_pls_golite062009
  • histone-lysine N-methyltransferase activity
    		•  0.858129308056814 bayes_pls_golite062009
  • RNA methyltransferase activity
    		•  0.817509452491588 bayes_pls_golite062009
  • site-specific DNA-methyltransferase (adenine-specific) activity
    		•  0.703178429468566 bayes_pls_golite062009
  • rRNA methyltransferase activity
    		•  0.230719796976667 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

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