Protein Overview: CG12267-PA, FBpp...

General Information:
Name(s) found:	FBpp0292147 [FlyBase] CG12267-PA / FBpp0082104 [FlyBase]
Description(s) found: Found 26 descriptions. SHOW ALL	type=protein; loc=3R:join(8286251..8286525,8286595..8287096,8287160..8287265,8287323..8287672,8287731..8287898,8287957..8288124); ID=FBpp0292147; name=CG12267-PB; parent=FBgn0038057,FBtr0303028; dbxref=FlyBase:FBpp0292147,FlyBase_Annotation_IDs:CG12267-PB,REFSEQ:NP_001189212,GB_protein:ADV37303; MD5=38608c2f4bbe16d89de31fc070a9fafd; length=522; release=r5.56; species=Dmel; [FlyBase] This gene is referred to in FlyBase by the symbol Dmel\CG12267 (CG12267, FBgn0038057). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:8286191..8288140. It has the cytological map location 87B11. Based on sequence similarity, it is predicted to have molecular function</span>: DNA-directed RNA polymerase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: transcription from RNA polymerase III promoter. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
Organism:	Drosophila melanogaster
Length:	522 amino acids
Gene Ontology:
Cellular Component:	DNA-directed RNA polymerase III complex [ISS]
Biological Process:	transcription from RNA polymerase III promoter [ISS] transcription [IEA]
Molecular Function:	DNA binding [IEA] DNA-directed RNA polymerase activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSADYSHLSS AILEQCFGKV VQAVADCLFS ATTRTLGQIT SATKLSRKEV AFALAVLVKF  60
   61 RLVDFAASKA NPFLAEYALR REDVLCLLRY PRYVHLVQTK YGNVGASISE ELINSGSDTA 120
  121 TGILLKCLAE NENKAESPES YRNTFLEMIT DHYIIKRPEL LVGDDQDENV PKFETNECDF 180
  181 FRHPNIDLQL LAKIQKGEAT LAEARDSHMV WHLNHDRFHQ DFRDTIMVDA IERKLGENAA 240
  241 ECFKFILKIM YNTTDPWERK LSNQITFVEI KQAIERKSNN LDLMKYLDQY ISLLTEDSLG 300
  301 FFRRVGDMGG GVYVVDMEHA FESLAFACVE CVITERFGSK AARIFRVIRC KKYIEQEDLQ 360
  361 KEAMIPSKEA KSLAYNLFQE QFIHVKIIKK PGGGSNGPAK AFYLFQVKEK DTVRMLLDAS 420
  421 YKSLYNTIER SNFEKNEHKG LIEKSQRLDS IVEAMKERGE TDEYIAEIVE TFTPPECEIL 480
  481 NKVKNRIKTL SKAELTLDDT IFLLQMYQHH CTTLPTGIRK FK

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..135]	FFAS03	1.31	X-ray crystal structure of putative HTH transcription regulator from Archaeoglobus fulgidus
2	View Details	[136..316]	Pfam	38.522879	No description for PF05645.4 was found. No confident structure predictions are available.
3	View Details	[317..437]	PSI-BLAST	4.0	An extended winged helix domain in general transcription factor E/IIE alpha
4	View Details	[438..522]	MSA	2.039995	View MSA. No confident structure predictions are available.

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
transcription regulator activity	5.23858959608048	bayes_pls_golite062009
DNA binding	4.78517210147551	bayes_pls_golite062009
nucleic acid binding	4.72059012764202	bayes_pls_golite062009
DNA-directed RNA polymerase activity	4.34522534923857	bayes_pls_golite062009
RNA polymerase activity	4.34522534923857	bayes_pls_golite062009
transcription factor activity	4.02736190679869	bayes_pls_golite062009
binding	3.37660003833383	bayes_pls_golite062009
nucleotidyltransferase activity	2.82260867370675	bayes_pls_golite062009
sequence-specific DNA binding	2.21432668306508	bayes_pls_golite062009
transferase activity	2.21031006146354	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	2.16473039675898	bayes_pls_golite062009
transcription activator activity	2.13702350917359	bayes_pls_golite062009
transcription repressor activity	1.9708626903609	bayes_pls_golite062009
RNA polymerase II transcription factor activity	1.50332889556988	bayes_pls_golite062009
transcription factor binding	0.752335897765285	bayes_pls_golite062009
protein binding	0.726445167461826	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.451714629708561	bayes_pls_golite062009

2

No functions predicted.

3

Term	Confidence	Notes
transcription regulator activity	5.55329976718261	bayes_pls_golite062009
DNA binding	5.08959163553491	bayes_pls_golite062009
nucleic acid binding	4.99681957904233	bayes_pls_golite062009
RNA polymerase activity	4.38040357248614	bayes_pls_golite062009
DNA-directed RNA polymerase activity	4.38040357248614	bayes_pls_golite062009
transcription factor activity	4.33152142980289	bayes_pls_golite062009
binding	3.52874320222492	bayes_pls_golite062009
nucleotidyltransferase activity	2.80876790343695	bayes_pls_golite062009
sequence-specific DNA binding	2.48053910222825	bayes_pls_golite062009
transcription activator activity	2.37668609508629	bayes_pls_golite062009
transcription repressor activity	2.22485867684613	bayes_pls_golite062009
transferase activity	2.17455387041569	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	2.13327310661537	bayes_pls_golite062009
RNA polymerase II transcription factor activity	1.70025468248325	bayes_pls_golite062009
transcription factor binding	0.85714789329232	bayes_pls_golite062009
protein binding	0.753698599635855	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.461477365615935	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	0.0856082199488197	bayes_pls_golite062009

4

No functions predicted.

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.93

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
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