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Protein Overview: mthl5-PA

General Information:
Name(s) found: mthl5-PA / FBpp0081989 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene methuselah-like 5 is referred to in FlyBase by the symbol Dmel\mthl5 (CG6965, FBgn0037960). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:7709660..7712887. It has the cytological map location 87A1. Based on sequence similarity, it is predicted to have molecular function</span>: G-protein coupled receptor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: G-protein coupled receptor protein signaling pathway; determination of adult lifespan; response to stress. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 496 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEA]
    integral to membrane [ISS][NAS]
    Biological Process: G-protein coupled receptor protein signaling pathway [ISS]
    determination of adult lifespan [ISS]
    cell surface receptor linked signaling pathway [IEA]
    response to stress [ISS]
    Molecular Function: G-protein coupled receptor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLVKTLGAHF AAGQNAKKCS CCALLISLLC VLLLSLNPLP VTSHVTSAGS STALSSDPNL  60
   61 VLVNKCCEKF EIHVDHECQQ VNETDYFQPM FTSYGGEQNR PVKFKFVIGI PNCGSMQMWP 120
  121 IYHYAGSSDK LVLLDDGRLR HYTNAENEAE ERHGIQSDYE EDIAGSLEPL YHDYDKGLYC 180
  181 IDKATSSTGE ENVLFANICL ARKEIKWSDS NFLLRKILNP IFHGISLVIL LVIAIIYFIL 240
  241 PTLRDLVGNI VTTIAMCLMV SQAADLVRIF TELTSHVSFI VADIILCFSL LAAFFWLNSF 300
  301 GFYIWKTFRS RNVFLRVTDG RKYCYYSAYA WGCTATMAAL AVFAHFFLDA ESYKQEHMVG 360
  361 EQETIGWLGI CIFFAPIACT ILVNIFFYVT TRKLINRRTV YGRIAHKLKA NFIMFSLMLL 420
  421 VMSIAWLFLI MSWLQMEGLL YAHIVVNALQ TPLLLYICVL RQRHVTFLLK KTCCYNEPPS 480
  481 ANDWGDELHY MNGNDY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..183] PSI-BLAST 24.154902 Methuselah ectodomain
    2 View Details [184..496] PSI-BLAST 46.0 No description for 2j4yA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • G-protein coupled receptor activity
    		•  7.48253527316663 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  5.76968261800439 bayes_pls_golite062009
  • receptor activity
    		•  5.47976284348283 bayes_pls_golite062009
  • signal transducer activity
    		•  4.51388461085202 bayes_pls_golite062009
  • molecular transducer activity
    		•  4.51388461085202 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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