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Protein Overview: CG4706-PA

General Information:
Name(s) found: CG4706-PA / FBpp0081812 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG4706 (CG4706, FBgn0037862). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:6962899..6965467. It has the cytological map location 86D4. Based on sequence similarity, it is predicted to have molecular function</span>: aconitate hydratase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: tricarboxylic acid cycle. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 783 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [ISS]
    Biological Process: tricarboxylic acid cycle [ISS]
    Molecular Function: 4 iron, 4 sulfur cluster binding [IEA]
    aconitate hydratase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQRTHRYIC LAGSMVRNFH TARFPRCDKV AMSNFDTGIP LPYKKLRENL DCIKGRLGGP  60
   61 LTLSEKVLYS HLDQPDSQEI ERGKSYLRLR PDRVALQDAT AQMTLLQFIS SGLKKVAVPS 120
  121 TVHCDHLIEA QISGDKDLAR AKDLNKEVYD FLSSACAKYN LGFWKPGSGI IHQIILENYA 180
  181 FPGLLMIGTD SHTPNGGGLG CLCVGVGGAD AVDVMANIPW ELKCPTVIGC HLTGKISGWT 240
  241 SPKDVILKVA EILTVKGGTG AIVEYHGPGV ESISCTGMAT ITNMGAEIGA TTSIFPFNER 300
  301 MVTYLRATGR GAIADEATKN KDLLVPDEGC KYDKVIEINL DTLEPLVNGP FTPDLAHPIS 360
  361 KLGQNSEKNG YPMEIKVSLI GSCTNSSYED MGRCASIAND ALGHGLKSCV PFNVTPGSEQ 420
  421 VRATIARDGI IDVLEKFGGT VLANACGPCI GQWDRKDVKM GEKNTIVTSY NRNFTGRNDA 480
  481 NPATHCFVTS PEMATALAIA GRLDFNPMTD ELTGTDGKTF KLKEPHGEEL PSKGFDPGED 540
  541 TYQAPPAKAD DIKVNVDPKS DRLQLLEPFE KWDGKDYIDL MVLIKIKGKC TTDHISAAGP 600
  601 WLKYRGHLDN ISNNMFIGAT NAENNEMNKV KNQKTGSFDA VPAVARDYKA NKIKWCAVGE 660
  661 ENYGEGSSRE HAALEPRHLG GVAIIVKSFA RIHETNLKKQ GMLALTFANP GDYDKVQPSS 720
  721 KISILNLKDL APGKPVDAEI KNNGSSDKIQ LNHTLNELQI QWFQAGSALN LMKELAAKGG 780
  781 DKK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..783] PSI-BLAST 1000.0 STRUCTURE OF ACTIVATED ACONITASE. FORMATION OF THE (4FE-4S) CLUSTER IN THE CRYSTAL

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • 3-isopropylmalate dehydratase activity
    		•  11.6597692115322 bayes_pls_golite062009
  • aconitate hydratase activity
    		•  5.86356477922338 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  2.93956285477489 bayes_pls_golite062009
  • catalytic activity
    		•  2.4040324437254 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.25736437672211 bayes_pls_golite062009
  • carbon-oxygen lyase activity
    		•  2.08349115784849 bayes_pls_golite062009
  • hydro-lyase activity
    		•  2.04845291489052 bayes_pls_golite062009
  • lyase activity
    		•  2.0080619912194 bayes_pls_golite062009
  • metal cluster binding
    		•  1.70706327499066 bayes_pls_golite062009
  • iron-sulfur cluster binding
    		•  1.70706327499066 bayes_pls_golite062009
  • binding
    		•  1.67914740974449 bayes_pls_golite062009
  • DNA binding
    		•  1.6436451615422 bayes_pls_golite062009
  • iron-responsive element binding
    		•  1.1980380564483 bayes_pls_golite062009
  • iron ion binding
    		•  1.12961684198784 bayes_pls_golite062009
  • 4 iron, 4 sulfur cluster binding
    		•  1.11810757572823 bayes_pls_golite062009
  • mRNA binding
    		•  1.0310744464034 bayes_pls_golite062009
  • structural molecule activity
    		•  0.870913754566634 bayes_pls_golite062009
  • RNA binding
    		•  0.42311333660604 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.342428816025605 bayes_pls_golite062009
  • protein binding
    		•  0.232638130896339 bayes_pls_golite062009
  • cation binding
    		•  0.0272064751959212 bayes_pls_golite062009
  • metal ion binding
    		•  0.0272064751959212 bayes_pls_golite062009
  • ion binding
    		•  0.0228992031160024 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.88

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle