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Protein Overview: MED7-PA

General Information:
Name(s) found: MED7-PA / FBpp0081787 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene Mediator complex subunit 7 is referred to in FlyBase by the symbol Dmel\MED7 (CG31390, FBgn0051390). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:6585793..6586754. It has the cytological map location 86C5. There is experimental evidence that it has the molecular function</span>: protein binding; RNA polymerase II transcription mediator activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: transcription initiation from RNA polymerase II promoter; transcription from RNA polymerase II promoter. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 220 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS]
    mediator complex [IC][IEA][ISS]
    Biological Process: transcription from RNA polymerase II promoter [IC][ISS]
    transcription initiation from RNA polymerase II promoter [ISS]
    regulation of transcription from RNA polymerase II promoter [IEA]
    Molecular Function: protein binding [IPI]
    transcription regulator activity [ISS]
    RNA polymerase II transcription mediator activity [IMP][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNQETQVSS LPMPPERYIA NYTDENIRRN RAPRPPPPPA QHEVYSMFGI QYNNDEMIRS  60
   61 LESQNIKRLI PIHFDRRKEL KKLNHSLLVN FLDLIDFLIL NPDSPRRTEK IDDISLLFVN 120
  121 MHHLLNEFRP HQARETLRVM MEMQKRQRVE TAARFQKHLE RVREIVNTAF SALPVLDDDD 180
  181 DSGGAKIKTE VDPLEANAAA KNDPSYQHDR MLCKLVDAIE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..103] Pfam 20.267606 No description for PF05983.2 was found. No confident structure predictions are available.
    2 View Details [104..220] PSI-BLAST 20.09691 Structure of the mediator MED7/MED21 subcomplex


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle